Preliminary Observations about the Ultrastructure of the Human Nail Plate Treated with Thioglycolic Acid

1968 ◽  
Vol 231 (4) ◽  
pp. 344-354 ◽  
Author(s):  
R. Caputo ◽  
E. Dadati
Keyword(s):  
Thioglycolic Acid ◽  
Nail Plate ◽  
Human Nail

scholarly journals Potential of Chemical and Physical Enhancers for Transungual Delivery of Amorolfine Hydrochloride

Materials ◽  
2019 ◽  
Vol 12 (7) ◽  
pp. 1028 ◽  
Author(s):  
Indrė Šveikauskaitė ◽  
Alius Pockevičius ◽  
Vitalis Briedis
Keyword(s):  
Co2 Laser ◽  
Antifungal Agent ◽  
Structural Changes ◽  
Thioglycolic Acid ◽  
Nail Plate ◽  
Drug Permeability ◽  
Fractional Co2 Laser ◽  
Human Nail ◽  
Effective Option ◽  
Eudragit E100

Topical monotherapy of nail infection is limited by poor drug permeability into the human nail plate. Numerous substances and methods are applied to improve the antifungal agent delivery across the nail plate. This work aimed to evaluate the effect of chemical and physical enhancers on the accumulation and permeation of amorolfine hydrochloride through human nail clippings. Polymeric nail lacquers with Eudragit E100 were developed as a potentially suitable delivery system for amorolfine hydrochloride. Incorporating thioglycolic acid and urea into formulations provided increased accumulation of antifungal agent in nail layers of up to 100% and 57%, respectively. Structural changes of nail barrier, induced by fractional CO2 laser, were visualized by microscopy. The permeation of amorolfine hydrochloride through the nail increased twofold when thioglycolic acid-containing formulation was applied and the nail was pretreated with a fractional CO2 laser. The results suggest that this novel combination of enhancers has the potential to be an effective option for topical drug delivery through the nail, and increased the efficacy of treatment.

In Vitro Penetration of a Novel Oxaborole Antifungal (AN2690) Into the Human Nail Plate

2007 ◽  
Vol 96 (10) ◽  
pp. 2622-2631 ◽  
Author(s):  
Xiaoying Hui ◽  
Stephen J. Baker ◽  
Ronald C. Wester ◽  
Sherry Barbadillo ◽  
Anne K. Cashmore ◽  
...  
Keyword(s):  
Nail Plate ◽  
Human Nail

Human nail bed‐derived decellularized scaffold regulates mesenchymal stem cells for nail plate regeneration

2019 ◽  
Vol 13 (10) ◽  
pp. 1770-1778 ◽  
Author(s):  
Yaling Yu ◽  
Haomin Cui ◽  
Demin Zhang ◽  
Bo Liang ◽  
Yimin Chai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Nail Plate ◽  
Nail Bed ◽  
Human Nail ◽  
Decellularized Scaffold

scholarly journals Proteomic Analysis of Human Nail Plate

2010 ◽  
Vol 9 (12) ◽  
pp. 6752-6758 ◽  
Author(s):  
Robert H. Rice ◽  
Yajuan Xia ◽  
Rudy J. Alvarado ◽  
Brett S. Phinney
Keyword(s):  
Proteomic Analysis ◽  
Nail Plate ◽  
Human Nail

A freeze-fracture study of the human nail plate

1981 ◽  
Vol 272 (1-2) ◽  
pp. 117-125 ◽  
Author(s):  
Ruggero Caputo ◽  
Giovanni Gasparini ◽  
Donata Contini
Keyword(s):  
Nail Plate ◽  
Freeze Fracture ◽  
Human Nail ◽  
Fracture Study

Ciclopirox delivery into the human nail plate using novel lipid diffusion enhancers

2013 ◽  
Vol 40 (6) ◽  
pp. 838-844 ◽  
Author(s):  
Farhaan Hafeez ◽  
Xiaoying Hui ◽  
Marc Selner ◽  
Bert Rosenthal ◽  
Howard Maibach
Keyword(s):  
Nail Plate ◽  
Human Nail ◽  
Lipid Diffusion

scholarly journals Poloxamer 407 Based Gel Formulations for Transungual Delivery of Hydrophobic Drugs: Selection and Optimization of Potential Additives

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3376
Author(s):  
Kamran Hidayat Ullah ◽  
Faisal Raza ◽  
Syed Mohsin Munawar ◽  
Muhammad Sohail ◽  
Hajra Zafar ◽  
...  
Keyword(s):  
Thioglycolic Acid ◽  
Drug Loading ◽  
Nail Plate ◽  
Gel Strength ◽  
Penetration Enhancer ◽  
Poloxamer 407 ◽  
Enhancement Effect ◽  
Hydrophobic Drugs ◽  
Gelation Temperature ◽  
Transungual Delivery

The current study aimed to develop poloxamer 407 (P407) gel for transungual delivery of antifungal hydrophobic drugs with sufficient gel strength and drug loading. Gel strength and drug loading of P407 gel was improved by use of functional additives. Hydration enhancement effect was used to select optimum nail penetration enhancer. Face-centered central composite design (FCCCD) was used to observe the effect of the selected penetration enhancer (thioglycolic acid (TGA)) and cosolvent (ethanol) on gelation behavior to develop formulation with enough loading of hydrophobic drug, i.e., terbinafine HCl (TBN), and its permeation across the nail plate without compromising on gel strength. It was observed that increasing concentration of P407 and TGA significantly reduced gelation temperature and enhanced the gel strength of P407 gel and can be used to improve P407 gel strength. Under the scanning electron microscope, the significant effect of TGA as an ungual penetration enhancer was observed on the morphology of the nail plate. Optimized P407 gel prepared with modified cold method showed a gelation temperature of 8.7 ± 0.16 °C, gel strength of 122 ± 7.5 s and drug loading of 1.2% w/w, which was four times more than the drug loading in the gels prepared with conventional cold method. Rheological behavior was pseudoplastic with 47.75 ± 3.48% of gel erosion after 12 washings and 67.21 ± 2.16% of drug release after 12 h. A cumulative amount of TBN permeated from P407 gel with and without PE after 24 h was 27.30 ± 4.18 and 16.69 ± 2.31 µg/cm2, respectively. Thioglycolic acid can be used as a nail penetration enhancer without the chemical modification or addition of extra additives while retaining the gel strength. Water miscible cosolvents with moderate evaporability such as ethanol, can be incorporated to P407 gel by minor modification in method of preparation to load the required dose of hydrophobic drugs. Developed P407 gel formulation with sufficient gel strength and drug loading will be a promising carrier for transungual delivery of hydrophobic antifungal agents.

Penetration of the human nail plate: the effects of vehicle pH on the permeation of miconazole

1985 ◽  
Vol 37 (7) ◽  
pp. 498-499 ◽  
Author(s):  
Kenneth A. Walters ◽  
Gordon L. Flynn ◽  
John R. Marvel
Keyword(s):  
Nail Plate ◽  
Human Nail
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