Receptor-mediated effects of serotonin and 5-methoxytryptamine on noradrenaline release in the rat vena cava and in the heart of the pithed rat

1986 ◽  
Vol 332 (2) ◽  
pp. 124-130 ◽  
Author(s):  
M. G�thert ◽  
E. Schlicker ◽  
P. Kollecker
Keyword(s):  
Noradrenaline Release ◽  
Vena Cava ◽  
Pithed Rat ◽  
Mediated Effects ◽  
Rat Vena Cava

CGP 35348 Blocks Noradrenaline- Release-Inhibiting GABAB Receptors in the Pig Retina, Rat Vena cava and Pithed Rat Vasculature

Pharmacology ◽  
1993 ◽  
Vol 47 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Eberhard Schlicker ◽  
Barbara Malinowska ◽  
Markus Kathmann
Keyword(s):  
Noradrenaline Release ◽  
Vena Cava ◽  
Pithed Rat ◽  
Rat Vena Cava ◽  
Cgp 35348

scholarly journals Noradrenaline release in the rat vena cava is inhibited by γ-aminobutyric acid via GABAB receptors but not affected by histamine

1991 ◽  
Vol 104 (2) ◽  
pp. 478-482 ◽  
Author(s):  
Dörthe Schneider ◽  
Eberhard Schlicker ◽  
Barbara Malinowska ◽  
Gerhard Molderings
Keyword(s):  
Noradrenaline Release ◽  
Vena Cava ◽  
Gabab Receptors ◽  
Aminobutyric Acid ◽  
Rat Vena Cava

Influence of spaceflight, hindlimb suspension, and venous occlusion on alpha 1-adrenoceptors in rat vena cava

1995 ◽  
Vol 78 (5) ◽  
pp. 1882-1888 ◽  
Author(s):  
I. Sayet ◽  
G. Neuilly ◽  
J. Mironneau ◽  
C. Mironneau
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Dissociation Constant ◽  
Binding Capacity ◽  
Vena Cava ◽  
Venous Occlusion ◽  
Hindlimb Suspension ◽  
Scatchard Analysis ◽  
Kinase C ◽  
Rat Vena Cava

Effects of hindlimb suspension, spaceflight, and venous occlusion were examined in isolated strips from rat vena cava by using both [3H]prazosin-binding and contraction responses evoked by norepinephrine. Sensitivity to norepinephrine was decreased without modification of the maximal contractile response. Furthermore, the high K(+)-induced contractions were not affected, suggesting that there was no interference with voltage-dependent Ca2+ channels. The sensitivity of the norepinephrine-induced contraction to prazosin was decreased, and Scatchard analysis of [3H]prazosin binding indicated an increase in the dissociation constant without variation in maximal binding capacity. A similar increase in the dissociation constant was obtained in control rats after pretreatment with 3 microM norepinephrine or 0.1 microM phorbol 12,13-dibutyrate to desensitize the protein kinase C. This effect was completely abolished in the presence of GF-109203X, a selective inhibitor of protein kinase C. Taken together, these data indicate that altered gravity conditions induce a desensitization of alpha 1B-adrenoceptors depending on increased protein kinase C activity. This effect can be mimicked by venous occlusion and may be responsible for reduced contractile responses to norepinephrine.

Islet-activating protein (pertussis toxin) diminishes ?2-adrenoceptor mediated effects on noradrenaline release

1985 ◽  
Vol 331 (2-3) ◽  
pp. 235-239 ◽  
Author(s):  
Clemens Allgaier ◽  
Thomas J. Feuerstein ◽  
Rolf Jackisch ◽  
Georg Hertting
Keyword(s):  
Pertussis Toxin ◽  
Noradrenaline Release ◽  
Mediated Effects
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