scholarly journals Ca2+−dependent contraction by the saponoside escin in rat vena cava: Implications in venotonic treatment of varicose veins

2011 ◽  
Vol 54 (2) ◽  
pp. 489-496 ◽  
Author(s):  
Joseph D. Raffetto ◽  
Raouf A. Khalil
Keyword(s):  
Varicose Veins ◽  
Vena Cava ◽  
Rat Vena Cava

Respiratory changes in biometry of suprarenal inferior vena cava in patients with varicose veins of lower extremities

2020 ◽  
pp. 026835552097413
Author(s):  
Yury Rusinovich ◽  
Volha Rusinovich
Keyword(s):  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Venous Return ◽  
Varicose Veins ◽  
Vena Cava ◽  
Lower Extremities ◽  
P Value ◽  
Venous Disease ◽  
Venous Compliance ◽  
Collapsibility Index

Aim This study examines respiratory biometry of inferior vena cava in patients with varicose veins of lower extremities. Material and Methods We performed retrospective analysis of clinical and ultrasound data of 67 patients with primary varicose veins. Results The largest expiratory (mean 16.2 mm, p-value 0.09) and inspiratory (mean 8.2 mm, p-value 0.02) inferior vena cava diameters were in C3 Clinical Etiological Anatomical Pathophysiological clinical class; the smallest expiratory diameters (mean 13.1 mm, p-value 0.5) were in C6 class; the smallest inspiratory diameters (mean 4.6 mm, intercept) were in C2 class. C2 class was associated with highest inferior vena cava collapsibility index (mean 68.2%, intercept); C6 class was associated with lowest collapsibility index (mean 48.3%, p-value 0.04). Recurrent varices in comparison with previously untreated were associated with smaller inspiratory diameters of inferior vena cava (mean 4.4 mm, p-value 0.005), smaller expiratory diameters (mean 13.4 mm, p-value 0.06) and higher collapsibility index (mean 68.5%, p-value 0.005). Patients with recurrent and bilateral varicose veins had identical respiratory biometry of inferior vena cava. Older age was associated with smaller inferior vena cava diameters (p-value <0.01). Conclusion Clinical presentation of varicose veins is associated with different respiratory biometry of suprarenal inferior vena cava. C6 clinical class in comparison with C2 clinical class is associated with lower central venous compliance possible due to the narrowing of inferior vena cava. Smaller inferior vena cava diameters and higher collapsibility index in recurrent subgroup in comparison with previously untreated can be a sign of the significantly altered pressure gradient between the systemic capillaries and the right heart and impaired peripheral venous return. Narrowing of inferior vena cava with age can be a sign of more profound changes in systemic venous return with age in patients with varicose veins in comparison to those without chronic venous disease.

Influence of spaceflight, hindlimb suspension, and venous occlusion on alpha 1-adrenoceptors in rat vena cava

1995 ◽  
Vol 78 (5) ◽  
pp. 1882-1888 ◽  
Author(s):  
I. Sayet ◽  
G. Neuilly ◽  
J. Mironneau ◽  
C. Mironneau
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Dissociation Constant ◽  
Binding Capacity ◽  
Vena Cava ◽  
Venous Occlusion ◽  
Hindlimb Suspension ◽  
Scatchard Analysis ◽  
Kinase C ◽  
Rat Vena Cava

Effects of hindlimb suspension, spaceflight, and venous occlusion were examined in isolated strips from rat vena cava by using both [3H]prazosin-binding and contraction responses evoked by norepinephrine. Sensitivity to norepinephrine was decreased without modification of the maximal contractile response. Furthermore, the high K(+)-induced contractions were not affected, suggesting that there was no interference with voltage-dependent Ca2+ channels. The sensitivity of the norepinephrine-induced contraction to prazosin was decreased, and Scatchard analysis of [3H]prazosin binding indicated an increase in the dissociation constant without variation in maximal binding capacity. A similar increase in the dissociation constant was obtained in control rats after pretreatment with 3 microM norepinephrine or 0.1 microM phorbol 12,13-dibutyrate to desensitize the protein kinase C. This effect was completely abolished in the presence of GF-109203X, a selective inhibitor of protein kinase C. Taken together, these data indicate that altered gravity conditions induce a desensitization of alpha 1B-adrenoceptors depending on increased protein kinase C activity. This effect can be mimicked by venous occlusion and may be responsible for reduced contractile responses to norepinephrine.

A model for passive elastic properties of rat vena cava

2007 ◽  
Vol 40 (14) ◽  
pp. 3130-3145 ◽  
Author(s):  
Georg Wolfgang Desch ◽  
Hans Werner Weizsäcker
Keyword(s):  
Elastic Properties ◽  
Vena Cava ◽  
Rat Vena Cava

Microfibrillar Elastic Polymer Wrapping of Rat Vena Cava for the Study of Engineered Arterial Vein Grafts

2010 ◽  
Author(s):  
Qiang Wang ◽  
Wei He ◽  
Yi Hong ◽  
William R. Wagner ◽  
David A. Vorp
Keyword(s):  
Saphenous Vein Graft ◽  
Vena Cava ◽  
Wall Stress ◽  
Cellular Injury ◽  
Vein Grafts ◽  
Ample Opportunity ◽  
Circumferential Wall Stress ◽  
Rat Vena Cava ◽  
Elastic Polymer ◽  
Polymer Wrapping

The autologous saphenous vein graft remains the graft of choice for 95% of surgeons performing coronary artery or peripheral bypass procedures. Within the first 5 years after implantation, 20%–40% of arterial vein grafts (AVG) fail due to intimal hyperplasia (IH)1. This adverse pathological response by AVGs may be in part due to their abrupt exposure to the significantly elevated circumferential wall stress associated with the arterial system2. We believe that if an AVG is given an ample opportunity to adapt and remodel to the stresses of the arterial environment, cellular injury may be reduced, thus limiting the initiating mechanisms of IH.

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