Saturation kinetics of the adrenergic neurone uptake system in the perfused rabbit heart. A new method for determination of initial rates of amine uptake

1978 ◽  
Vol 302 (3) ◽  
pp. 263-273 ◽  
Author(s):  
K. -H. Graefe ◽  
H. B�nisch ◽  
B. Keller
Keyword(s):  
Rabbit Heart ◽  
New Method ◽  
Uptake System ◽  
Perfused Rabbit Heart ◽  
Saturation Kinetics ◽  
Amine Uptake ◽  
Kinetics Of ◽  
Adrenergic Neurone

scholarly journals Myocardial Kinetics of a Novel [18F]-Labeled Sympathetic Nerve PET Tracer LMI1195 in the Isolated Perfused Rabbit Heart

2015 ◽  
Vol 8 (10) ◽  
pp. 1229-1231 ◽  
Author(s):  
Takahiro Higuchi ◽  
Behrooz H. Yousefi ◽  
Sybille Reder ◽  
Monika Beschorner ◽  
Iina Laitinen ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Rabbit Heart ◽  
Perfused Rabbit Heart ◽  
Pet Tracer ◽  
Kinetics Of

Myocardial uptake kinetics of tocainide enantiomers in the isolated perfused rabbit heart

Chirality ◽  
1995 ◽  
Vol 7 (3) ◽  
pp. 163-166
Author(s):  
Ellen Bech Christensen ◽  
Steen Honor� Hansen ◽  
S�ren N�rgaard Rasmussen
Keyword(s):  
Rabbit Heart ◽  
Uptake Kinetics ◽  
Myocardial Uptake ◽  
Perfused Rabbit Heart ◽  
Kinetics Of

Interaction of paraquat and amine uptake by rat lungs perfused in situ

1985 ◽  
Vol 249 (5) ◽  
pp. E506-E513 ◽  
Author(s):  
D. E. Rannels ◽  
A. E. Pegg ◽  
R. S. Clark ◽  
J. L. Addison
Keyword(s):  
Pulmonary Circulation ◽  
Methyl Glyoxal ◽  
Uptake Pathway ◽  
Rat Lungs ◽  
Uptake Rates ◽  
Saturation Kinetics ◽  
Amine Uptake ◽  
Cellular Permeability ◽  
Kinetics Of

The kinetics of [14C]paraquat (N,N-di[14C]methyl-4,4'-bipyridylium) uptake from the pulmonary circulation were investigated in rat lungs perfused in situ. During the 1st h of exposure to the herbicide paraquat entered the lungs primarily by diffusion; no evidence was obtained from concentrative uptake, saturation kinetics (1-3,500 microM paraquat), or inhibition by the amines methyl-glyoxal bis(guanylhydrazone) or spermidine, both of which were expected to compete for paraquat transport sites. In contrast, after 60 min of exposure, uptake rates increased two- to three-fold, and paraquat was accumulated to an apparent intracellular concentration greater than that in the perfusate. The latter phase of paraquat uptake was saturable and was inhibited by methylglyoxal bis(guanylhydrazone); it did not appear to reflect a progressive paraquat-induced alteration in cellular permeability but rather predominance of a rapid, carrier-mediated uptake pathway.

Potassium flux in the isolated perfused rabbit heart

1960 ◽  
Vol 198 (6) ◽  
pp. 1217-1222 ◽  
Author(s):  
E. W. Humphrey ◽  
J. A. Johnson
Keyword(s):  
Activation Energy ◽  
Potassium Concentration ◽  
Relative Size ◽  
Rabbit Heart ◽  
Extracellular Potassium ◽  
Perfused Rabbit Heart ◽  
Potassium Flux ◽  
Exchange Kinetics ◽  
Kinetics Of ◽  
Total Potassium

The exchange kinetics of potassium in the isolated, perfused rabbit heart have been studied in relation to changes in heart rate, extracellular potassium and temperature. The intracellular potassium appeared to exist in at least two compartments, the relative size varying with the extracellular concentration of potassium. The change in the potassium flux between heart rates of 100 and 200 beats/min. was compared to a change in flux calculated on the basis of the theory proposed by Hodgkin and co-workers and electrical constants taken from the literature. The change in flux estimated from the experimental curves was somewhat smaller than that required by theory and a discussion of this result is given. The activation energy calculated for the total potassium flux into and from the cells was estimated to be from 3000 to 8000 cal/ mole and found to be a function of the potassium concentration in the perfusate.

A new method for the determination of nitrates

1960 ◽  
Vol 23 ◽  
pp. 227-232 ◽  
Author(s):  
P WEST ◽  
G LYLES
Keyword(s):  
New Method
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