Myocardial uptake kinetics of tocainide enantiomers in the isolated perfused rabbit heart

Chirality ◽  
1995 ◽  
Vol 7 (3) ◽  
pp. 163-166
Author(s):  
Ellen Bech Christensen ◽  
Steen Honor� Hansen ◽  
S�ren N�rgaard Rasmussen
Keyword(s):  
Rabbit Heart ◽  
Uptake Kinetics ◽  
Myocardial Uptake ◽  
Perfused Rabbit Heart ◽  
Kinetics Of

scholarly journals Myocardial Kinetics of a Novel [18F]-Labeled Sympathetic Nerve PET Tracer LMI1195 in the Isolated Perfused Rabbit Heart

2015 ◽  
Vol 8 (10) ◽  
pp. 1229-1231 ◽  
Author(s):  
Takahiro Higuchi ◽  
Behrooz H. Yousefi ◽  
Sybille Reder ◽  
Monika Beschorner ◽  
Iina Laitinen ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Rabbit Heart ◽  
Perfused Rabbit Heart ◽  
Pet Tracer ◽  
Kinetics Of

MYOCARDIAL UPTAKE OF LIDOCAINE IN THE ISOLATED PERFUSED RABBIT HEART

1989 ◽  
Vol 71 (Supplement) ◽  
pp. A291 ◽  
Author(s):  
J X Mazoit ◽  
J M Talmant ◽  
E E Orhant ◽  
J P Kantelip
Keyword(s):  
Rabbit Heart ◽  
Myocardial Uptake ◽  
Perfused Rabbit Heart

Potassium flux in the isolated perfused rabbit heart

1960 ◽  
Vol 198 (6) ◽  
pp. 1217-1222 ◽  
Author(s):  
E. W. Humphrey ◽  
J. A. Johnson
Keyword(s):  
Activation Energy ◽  
Potassium Concentration ◽  
Relative Size ◽  
Rabbit Heart ◽  
Extracellular Potassium ◽  
Perfused Rabbit Heart ◽  
Potassium Flux ◽  
Exchange Kinetics ◽  
Kinetics Of ◽  
Total Potassium

The exchange kinetics of potassium in the isolated, perfused rabbit heart have been studied in relation to changes in heart rate, extracellular potassium and temperature. The intracellular potassium appeared to exist in at least two compartments, the relative size varying with the extracellular concentration of potassium. The change in the potassium flux between heart rates of 100 and 200 beats/min. was compared to a change in flux calculated on the basis of the theory proposed by Hodgkin and co-workers and electrical constants taken from the literature. The change in flux estimated from the experimental curves was somewhat smaller than that required by theory and a discussion of this result is given. The activation energy calculated for the total potassium flux into and from the cells was estimated to be from 3000 to 8000 cal/ mole and found to be a function of the potassium concentration in the perfusate.

Metabolism of the isolated perfused rabbit heart. III. Energy stores and creatine kinase release during prolonged reoxygenation and atrial pacing

1979 ◽  
Vol 57 (10) ◽  
pp. 1058-1066 ◽  
Author(s):  
Miguel A. Chiong ◽  
Timothy L. Winton
Keyword(s):  
Creatine Kinase ◽  
Mechanical Performance ◽  
Recovery Period ◽  
Systolic Pressure ◽  
Rabbit Heart ◽  
Left Ventricular ◽  
Atrial Pacing ◽  
Myocardial Uptake ◽  
Ventricular Systolic Pressure ◽  
Perfused Rabbit Heart

When the perfused rabbit heart is reoxygenated for 75 min after 25 min of anoxic perfusion, left ventricle performance stabilizes at 50% of control levels, but the rate of creatine kinase (CK) release is high (1.9 U/min) and ATP stores are low (5 μmol/g dry weight). These results suggest that the preparation is on the verge of severe failure. This possibility was investigated by following the recovery for an extra 60 min of reoxygenation and by stressing the hearts with atrial pacing.The data show that no deterioration occurred during the extra recovery period; on the contrary, mechanical performance remained stable, while the rate of CK release fell to 1.1 U/min, and ATP stores increased by 204%. In aerobic hearts, pacing increased the product of left ventricular systolic pressure (LVSP) and heart rate, myocardial uptake of oxygen [Formula: see text], coronary sinus flow, and O2 extraction, but LVSP and [Formula: see text] per beat fell. Similar responses were seen in postanoxic hearts, but LVSP improved during pacing while the rate of CK loss declined and ATP stores increased. These metabolic changes were inversely related to the rate of contraction. It is concluded that the preparation was not deteriorating at 75 min of reoxygenation, and that its metabolism was improved by cardiac pacing.

Influence of phosphate status on phosphate uptake kinetics of maize (Zea mays) and soybean (Glycine max)

1990 ◽  
Vol 124 (2) ◽  
pp. 175-182 ◽  
Author(s):  
A. Jungk ◽  
C. J. Asher ◽  
D. G. Edwards ◽  
D. Meyer
Keyword(s):  
Zea Mays ◽  
Glycine Max ◽  
Phosphate Uptake ◽  
Uptake Kinetics ◽  
Kinetics Of

High-resolution1H NMR imaging of regional ischemia in the isolated perfused rabbit heart at 4.7 T

1991 ◽  
Vol 21 (1) ◽  
pp. 144-150 ◽  
Author(s):  
John C. Chatham ◽  
Stacey Ackerman ◽  
Stephen J. Blackband
Keyword(s):  
Rabbit Heart ◽  
Nmr Imaging ◽  
Regional Ischemia ◽  
Perfused Rabbit Heart
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