Noradrenaline uptake inhibitors do not reduce the presynaptic action of clonidine on 3H-noradrenaline release in superfused synaptosomes

1984 ◽  
Vol 327 (1) ◽  
pp. 86-89 ◽  
Author(s):  
Guido Maura ◽  
Anna Pittaluga ◽  
Annamaria Ricchetti ◽  
Maurizio Raiteri
Keyword(s):  
Noradrenaline Release ◽  
Noradrenaline Uptake ◽  
Presynaptic Action ◽  
Superfused Synaptosomes ◽  
Uptake Inhibitors ◽  
Noradrenaline Uptake Inhibitors

Effect of neuronal uptake inhibitors on the adrenergic-neuron blockade produced by guanethidine in rabbit vas deferens

1977 ◽  
Vol 55 (3) ◽  
pp. 609-614 ◽  
Author(s):  
L. J. Huston ◽  
D. S. Golko ◽  
D. M. Paton
Keyword(s):  
Vas Deferens ◽  
Neuronal Uptake ◽  
Noradrenaline Uptake ◽  
Adrenergic Neuron ◽  
Serotonin Uptake Inhibitor ◽  
Uptake Inhibitors ◽  
Subsequent Exposure ◽  
Noradrenaline Uptake Inhibitors ◽  
Rabbit Vas Deferens ◽  
Sustained Responses

The effect of neuronal-uptake inhibitors on the guanethidine-induced inhibition of responses of rabbit vas deferens to transmural stimulation was investigated. The twitch and sustained reponses were inhibited by about 70% by 1.2 × 10−5 M guanethidine. Prior or subsequent exposure to the noradrenaline-uptake inhibitors, 3.3 × 10−5 M cocaine, 10−5 M nisoxetine, and 10−7 M desipramine prevented or reversed these effects of guanethidine. The depressant effects of guanethidine were not modified by the serotonin-uptake inhibitor, 10−6 M fluoxetine. The uptake of 5 × 10−8 M (−)-[3H]noradrenaline by rabbit vas deferens was significantly reduced by guanethidine, cocaine, nisoxetine, and desipramine, but not by fluoxetine. It was concluded that guanethidine inhibited both the twitch and sustained responses of the vas by producing adrenergic-neuron blockade and that these effects were dependent on continued transport into adrenergic neurons.

Correlation Between Noradrenaline Fluxes, Metabolism and Compartmentalisation in Human Platelets

1982 ◽  
Vol 48 (01) ◽  
pp. 062-066 ◽  
Author(s):  
Chantal Legrand ◽  
Véronique Dubernard ◽  
Philippe Meyer
Keyword(s):  
Noradrenaline Release ◽  
Human Platelets ◽  
Release Of Noradrenaline ◽  
Storage Pool ◽  
Platelet Storage ◽  
Efflux Of Noradrenaline ◽  
Preferential Localization

Summary(3H) noradrenaline was taken up by human platelets and partially converted into sulfoconjugated noradrenaline. This uptake was inhibited by drugs which have been previously shown to impair the uptake of 5-HT (ouabain, chlorimipramine) or the storage of 5-HT (tyramine, reserpine) by platelets. In addition, tyramine and reserpine stimulated the formation of sulfoconjugated noradrenaline. The efflux of noradrenaline from platelets was measured in parallel and was found to be directly related to the proportion of non metabolized to metabolized noradrenaline in the cells. Unlike tyramine, which induced a similar release of noradrenaline and 5-HT, reserpine was less effective at inducing noradrenaline release than 5-HT release. This study indicates a preferential localization of noradrenaline in the granular pool of human platelets with the existence of an extragranular sulfoconjugated pool which is increased when the granular storage of noradrenaline is impaired. Studies of noradrenaline fluxes and metabolism may be useful in the understanding of both acquired and inherited platelet storage pool defects.

Selective Serotonin Re-Uptake Inhibitors and Hyponatremia in Acutely Medically-Ill Inpatients

2016 ◽  
Vol 11 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Saeid Noohi ◽  
André Do ◽  
Dominique Elie ◽  
Artin A. Mahdanian ◽  
Ching Yu ◽  
...  
Keyword(s):  
Selective Serotonin ◽  
Medically Ill ◽  
Uptake Inhibitors
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