Presynaptic action of adrenaline on adrenoceptors modulating stimulation-evoked 3H-noradrenaline release from rabbit isolated aorta

1989 ◽  
Vol 339 (3) ◽  
Author(s):  
Jan Abrahamsen ◽  
OveA. Nedergaard
Keyword(s):  
Noradrenaline Release ◽  
Presynaptic Action ◽  
Isolated Aorta

Correlation Between Noradrenaline Fluxes, Metabolism and Compartmentalisation in Human Platelets

1982 ◽  
Vol 48 (01) ◽  
pp. 062-066 ◽  
Author(s):  
Chantal Legrand ◽  
Véronique Dubernard ◽  
Philippe Meyer
Keyword(s):  
Noradrenaline Release ◽  
Human Platelets ◽  
Release Of Noradrenaline ◽  
Storage Pool ◽  
Platelet Storage ◽  
Efflux Of Noradrenaline ◽  
Preferential Localization

Summary(3H) noradrenaline was taken up by human platelets and partially converted into sulfoconjugated noradrenaline. This uptake was inhibited by drugs which have been previously shown to impair the uptake of 5-HT (ouabain, chlorimipramine) or the storage of 5-HT (tyramine, reserpine) by platelets. In addition, tyramine and reserpine stimulated the formation of sulfoconjugated noradrenaline. The efflux of noradrenaline from platelets was measured in parallel and was found to be directly related to the proportion of non metabolized to metabolized noradrenaline in the cells. Unlike tyramine, which induced a similar release of noradrenaline and 5-HT, reserpine was less effective at inducing noradrenaline release than 5-HT release. This study indicates a preferential localization of noradrenaline in the granular pool of human platelets with the existence of an extragranular sulfoconjugated pool which is increased when the granular storage of noradrenaline is impaired. Studies of noradrenaline fluxes and metabolism may be useful in the understanding of both acquired and inherited platelet storage pool defects.

1914 Conditioned fear increases noradrenaline release in the rat basolateral amygdaloid nucleus: Assessed by in vivo microdialysis

1993 ◽  
Vol 18 ◽  
pp. S215
Author(s):  
Hiroshi Kawahara ◽  
Masami Yoshida ◽  
Hideyasu Yokoo ◽  
Masakatsu Nishi ◽  
Masatoshi Tanaka
Keyword(s):  
Noradrenaline Release ◽  
Conditioned Fear ◽  
In Vivo Microdialysis ◽  
Amygdaloid Nucleus

scholarly journals Constitutive activity of the A2A adenosine receptor and compartmentalised cyclic AMP signalling fine-tune noradrenaline release

2012 ◽  
Vol 8 (4) ◽  
pp. 677-692 ◽  
Author(s):  
Edin Ibrisimovic ◽  
Helmut Drobny ◽  
Qiong Yang ◽  
Thomas Höfer ◽  
Stefan Boehm ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Noradrenaline Release ◽  
Adenosine Receptor ◽  
Constitutive Activity ◽  
A2a Adenosine Receptor ◽  
Fine Tune
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