The neuronal efflux of noradrenaline: Dependency on sodium and facilitation by ouabain

1974 ◽  
Vol 284 (1) ◽  
pp. 93-100 ◽  
Author(s):  
R. Lindmar ◽  
K. L�ffelholz
Keyword(s):  
Efflux Of Noradrenaline ◽  
Neuronal Efflux

Correlation Between Noradrenaline Fluxes, Metabolism and Compartmentalisation in Human Platelets

1982 ◽  
Vol 48 (01) ◽  
pp. 062-066 ◽  
Author(s):  
Chantal Legrand ◽  
Véronique Dubernard ◽  
Philippe Meyer
Keyword(s):  
Noradrenaline Release ◽  
Human Platelets ◽  
Release Of Noradrenaline ◽  
Storage Pool ◽  
Platelet Storage ◽  
Efflux Of Noradrenaline ◽  
Preferential Localization

Summary(3H) noradrenaline was taken up by human platelets and partially converted into sulfoconjugated noradrenaline. This uptake was inhibited by drugs which have been previously shown to impair the uptake of 5-HT (ouabain, chlorimipramine) or the storage of 5-HT (tyramine, reserpine) by platelets. In addition, tyramine and reserpine stimulated the formation of sulfoconjugated noradrenaline. The efflux of noradrenaline from platelets was measured in parallel and was found to be directly related to the proportion of non metabolized to metabolized noradrenaline in the cells. Unlike tyramine, which induced a similar release of noradrenaline and 5-HT, reserpine was less effective at inducing noradrenaline release than 5-HT release. This study indicates a preferential localization of noradrenaline in the granular pool of human platelets with the existence of an extragranular sulfoconjugated pool which is increased when the granular storage of noradrenaline is impaired. Studies of noradrenaline fluxes and metabolism may be useful in the understanding of both acquired and inherited platelet storage pool defects.

The relation between in vitro. efflux of noradrenaline from platelets and vas deferens in man

1985 ◽  
Vol 125 (1) ◽  
pp. 155-158 ◽  
Author(s):  
INGRID MATTIASSON ◽  
IRENE NYSTRÖM ◽  
PER-ANDERS ABRAHAMSSON ◽  
BERTIL HOOD
Keyword(s):  
Vas Deferens ◽  
Efflux Of Noradrenaline

scholarly journals SIRT1 promotes neuronal fortification in neurodegenerative diseases through attenuation of pathological hallmarks and enhancement of cellular lifespan

2020 ◽  
Vol 18 ◽  
Author(s):  
Priya Mishra ◽  
Amit Kumar Mittal ◽  
Harikesh Kalonia ◽  
Swati Madan ◽  
Shampa Ghosh ◽  
...  
Keyword(s):  
Motor Coordination ◽  
Inflammatory Responses ◽  
Neuronal Loss ◽  
Genomic Stability ◽  
Therapeutic Agents ◽  
Age Related ◽  
The Family ◽  
Neuronal Efflux ◽  
Growth Energy

: Neurodegeneration is a complex neurological phenomenon characterized by disturbed coherence in neuronal efflux. Progressive neuronal loss and brain damage due to various age-related pathological hallmarks perturb the behavioral balance and quality of life. Sirtuins have been widely investigated for their neuroprotective role, with SIRT1 being the most contemplated member of the family. SIRT1 exhibits significant capabilities to enhance neurogenesis and cellular lifespan by regulating various pathways, which makes it an exciting therapeutic target to inhibit neurodegenerative disease progression. SIRT1 mediated neuronal fortification involves modulation of molecular co-factors and biochemical pathways responsible for the induction and sustenance of pro-inflammatory and pro-oxidative environment in the cellular milieu. In this review, we present the major role played by SIRT1 in maintaining cellular strength through the regulation of genomic stability, neuronal growth, energy metabolism, oxidative stress, inhibiting mechanisms and anti-inflammatory responses. The therapeutic significance of SIRT1 has been put into perspective through a comprehensive discussion about its ameliorating potential against neurodegenerative stimuli in a variety of diseases that characteristically impair cognition, memory and motor coordination. This review enhances the acquaintance concerned with the neuroprotective potential of SIRT1 and thus promotes the development of novel SIRT1 regulating therapeutic agents and strategies.

The Influence of Cations on Spontaneous and Chemically Induced Efflux of Noradrenaline from Perfused Rat Hearts

1972 ◽  
Vol 50 (6) ◽  
pp. 490-497 ◽  
Author(s):  
C. W. Nash ◽  
G. S. Taylor ◽  
T. E. Drouin
Keyword(s):  
Barium Ions ◽  
Efflux Of Noradrenaline ◽  
Chemically Induced ◽  
Rat Hearts ◽  
Na Efflux ◽  
Perfused Rat Hearts ◽  
Ca Ions ◽  
Storage Granules ◽  
Limited Supply ◽  
Na Release

Isolated rat hearts perfused with Krebs bicarbonate solution and labelled with 3H-noradrenaline (3H-NA) were used to study the influence of various cations on the efflux of noradrenaline from sympathetic nerve endings. Evidence is presented that EDTA causes release by influencing Mg more than Ca ions, possibly those associated in a Mg–ATPase complex at the storage granule. Calcium is required for release by excess potassium but inhibits release caused by BaCl2. In contrast to sustained increases in the rate of 3H-NA efflux caused by EDTA and noradrenaline, potassium and barium ions initiate short-duration increases which subside while the initiating agent is still present. It is postulated that potassium and barium may cause 3H-NA release from a limited pool of granules adjacent to the membrane or may make available a limited supply of intracellular free Ca ions to initiate release at the storage granules.

Uptake and Efflux of Noradrenaline from Platelets; a Model System for Neurogenic Mechanisms in Essential Hypertension

1979 ◽  
Vol 57 (s5) ◽  
pp. 225s-227s ◽  
Author(s):  
I. Mattiasson ◽  
B. Mattiasson ◽  
B. Hood
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Family History ◽  
Model System ◽  
Efflux Rate ◽  
Efflux Of Noradrenaline ◽  
High K ◽  
History Of ◽  
Family History Of Hypertension ◽  
Very High

1. The rate (k) of initial efflux of noradrenaline from platelets was determined in 63 individuals. A highly significant correlation was found between diastolic blood pressure and efflux rate. 2. When platelets are incubated in buffers with various Na+ concentrations in the range 110–170 mmol/l a higher Na+ concentration will give a faster efflux of noradrenaline for each concentration tested. 3. The value for k was determined in 41 normotensive first-degree relatives of hypertensive individuals and 21 persons with no family history of hypertension. Efflux rate of noradrenaline was significantly higher in the relatives and within this group was a subgroup with very high k values.

Efflux of Noradrenaline from Platelets in Normotensive Members of Hypertensive Families

1982 ◽  
Vol 62 (2) ◽  
pp. 151-155 ◽  
Author(s):  
Ingrid Mattiasson ◽  
B. Hood
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Family History ◽  
Sympathetic Neurons ◽  
A Priori ◽  
Middle Aged ◽  
Efflux Rate ◽  
Efflux Of Noradrenaline ◽  
Two Generations ◽  
History Of

1. Platelets have been used as a model of sympathetic neurons to study the storage of noradrenaline in normotensive individuals belonging to families with essential hypertension for at least two generations. 2. The initial efflux rate (k) of noradrenaline was determined in 44 young relatives (mean age 29.2 years), in 18 middle-aged relatives (mean age 46.7 years) and in 31 young controls with no known family history of essential hypertension (mean age 29.8 years). From the groups of relatives all those with definite hypertension had been excluded a priori. 3. k was significantly higher in the young relatives (22.7 ± 7.9) than in the middle-aged relatives (17.7 ± 6.4) and in the controls (15.6 ± 5.1). Of the relatives 27.3% had higher k values than any of the controls. A significant correlation was found between k and diastolic blood pressure in controls but not in young relatives.

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