Differences in the metabolism of the aromatic amino acid hydroxylase cofactor, tetrahydrobiopterin, in mutant mice with neurological and immunological defects

1986 ◽  
Vol 24 (9-10) ◽  
pp. 657-668 ◽  
Author(s):  
David S. Duch ◽  
Seaton W. Bowers ◽  
Jeffrey H. Woolf ◽  
Muriel T. Davisson ◽  
Lois J. Maltais ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Mutant Mice ◽  
Aromatic Amino Acid Hydroxylase

ChemInform Abstract: AROMATIC AMINO ACID HYDROXYLASE INHIBITORS PART 3, IN VITRO INHIBITION BY AZADOPAMINE ANALOGS

1974 ◽  
Vol 5 (19) ◽  
pp. no-no
Author(s):  
L. E. HARE ◽  
M. C. LU ◽  
C. B. SULLIVAN ◽  
P. T. SULLIVAN ◽  
R. E. COUNSELL ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aromatic Amino Acid Hydroxylase ◽  
In Vitro Inhibition

scholarly journals Chlamydia pneumoniaeencodes a functional aromatic amino acid hydroxylase

2009 ◽  
Vol 55 (2) ◽  
pp. 196-205 ◽  
Author(s):  
Stephanie Abromaitis ◽  
P. Scott Hefty ◽  
Richard S. Stephens
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aromatic Amino Acid Hydroxylase

Aromatic amino acid hydroxylase inhibitors. 2. 3-Alkyl-.alpha.-methyltyrosines

1971 ◽  
Vol 14 (9) ◽  
pp. 789-792 ◽  
Author(s):  
R. E. Counsell ◽  
P. Desai ◽  
A. Ide ◽  
P. G. Kulkarni ◽  
P. A Weinhold ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aromatic Amino Acid Hydroxylase

scholarly journals Phylogenetic analysis and evolution of aromatic amino acid hydroxylase

FEBS Letters ◽  
2010 ◽  
Vol 584 (23) ◽  
pp. 4775-4782 ◽  
Author(s):  
Jun Cao ◽  
Feng Shi ◽  
Xiaoguang Liu ◽  
Guang Huang ◽  
Min Zhou
Keyword(s):  
Phylogenetic Analysis ◽  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aromatic Amino Acid Hydroxylase

Aromatic amino acid hydroxylase inhibitors. 3. In vitro inhibition by azadopamine analogs

1974 ◽  
Vol 17 (1) ◽  
pp. 1-5 ◽  
Author(s):  
L. E. Hare ◽  
M. C. Lu ◽  
C. B. Sullivan ◽  
P. T. Sullivan ◽  
R. E. Counsell ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aromatic Amino Acid Hydroxylase ◽  
In Vitro Inhibition

scholarly journals Reassessment of the Role of Aromatic Amino Acid Hydroxylases and the Effect of Infection by Toxoplasma gondii on Host Dopamine

2014 ◽  
Vol 83 (3) ◽  
pp. 1039-1047 ◽  
Author(s):  
Zi T. Wang ◽  
Steve Harmon ◽  
Karen L. O'Malley ◽  
L. David Sibley
Keyword(s):  
Amino Acid ◽  
Toxoplasma Gondii ◽  
Aromatic Amino Acid ◽  
Content Type ◽  
Aromatic Amino Acid Hydroxylase ◽  
Aromatic Amino Acid Hydroxylases ◽  
Host Brain

Toxoplasma gondiiinfection has been described previously to cause infected mice to lose their fear of cat urine. This behavioral manipulation has been proposed to involve alterations of host dopamine pathways due to parasite-encoded aromatic amino acid hydroxylases. Here, we report successful knockout and complementation of the aromatic amino acid hydroxylaseAAH2gene, with no observable phenotype in parasite growth or differentiationin vitroandin vivo. Additionally, expression levels of the two aromatic amino acid hydroxylases were negligible both in tachyzoites and in bradyzoites. Finally, we were unable to confirm previously described effects of parasite infection on host dopamine eitherin vitroorin vivo, even whenAAH2was overexpressed using theBAG1promoter. Together, these data indicate that AAH enzymes in the parasite do not cause global or regional alterations of dopamine in the host brain, although they may affect this pathway locally. Additionally, our findings suggest alternative roles for theAHHenzymes inT. gondii, sinceAAH1is essential for growth in nondopaminergic cells.

Aromatic amino acid hydroxylase inhibitors. I. Halogenated phenylalanines

1970 ◽  
Vol 13 (6) ◽  
pp. 1040-1042 ◽  
Author(s):  
Raymond E. Counsell ◽  
P. Desai ◽  
Terry Douglas Smith ◽  
Peter S. Chan ◽  
P. A. Weinhold ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aromatic Amino Acid Hydroxylase

ChemInform Abstract: AROMATIC AMINO ACID HYDROXYLASE INHIBITORS PART 4, 3-SUBSTITUTED ALPHA-METHYLTYROSINES

1975 ◽  
Vol 6 (19) ◽  
pp. no-no
Author(s):  
A. H. EL MASRY ◽  
S. E. EL MASRY ◽  
L. E. HARE ◽  
R. E. COUNSELL
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aromatic Amino Acid Hydroxylase
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