Aromatic amino acid hydroxylase inhibitors. 3. In vitro inhibition by azadopamine analogs

1974 ◽  
Vol 17 (1) ◽  
pp. 1-5 ◽  
Author(s):  
L. E. Hare ◽  
M. C. Lu ◽  
C. B. Sullivan ◽  
P. T. Sullivan ◽  
R. E. Counsell ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aromatic Amino Acid Hydroxylase ◽  
In Vitro Inhibition

ChemInform Abstract: AROMATIC AMINO ACID HYDROXYLASE INHIBITORS PART 3, IN VITRO INHIBITION BY AZADOPAMINE ANALOGS

1974 ◽  
Vol 5 (19) ◽  
pp. no-no
Author(s):  
L. E. HARE ◽  
M. C. LU ◽  
C. B. SULLIVAN ◽  
P. T. SULLIVAN ◽  
R. E. COUNSELL ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aromatic Amino Acid Hydroxylase ◽  
In Vitro Inhibition

scholarly journals Reassessment of the Role of Aromatic Amino Acid Hydroxylases and the Effect of Infection by Toxoplasma gondii on Host Dopamine

2014 ◽  
Vol 83 (3) ◽  
pp. 1039-1047 ◽  
Author(s):  
Zi T. Wang ◽  
Steve Harmon ◽  
Karen L. O'Malley ◽  
L. David Sibley
Keyword(s):  
Amino Acid ◽  
Toxoplasma Gondii ◽  
Aromatic Amino Acid ◽  
Content Type ◽  
Aromatic Amino Acid Hydroxylase ◽  
Aromatic Amino Acid Hydroxylases ◽  
Host Brain

Toxoplasma gondiiinfection has been described previously to cause infected mice to lose their fear of cat urine. This behavioral manipulation has been proposed to involve alterations of host dopamine pathways due to parasite-encoded aromatic amino acid hydroxylases. Here, we report successful knockout and complementation of the aromatic amino acid hydroxylaseAAH2gene, with no observable phenotype in parasite growth or differentiationin vitroandin vivo. Additionally, expression levels of the two aromatic amino acid hydroxylases were negligible both in tachyzoites and in bradyzoites. Finally, we were unable to confirm previously described effects of parasite infection on host dopamine eitherin vitroorin vivo, even whenAAH2was overexpressed using theBAG1promoter. Together, these data indicate that AAH enzymes in the parasite do not cause global or regional alterations of dopamine in the host brain, although they may affect this pathway locally. Additionally, our findings suggest alternative roles for theAHHenzymes inT. gondii, sinceAAH1is essential for growth in nondopaminergic cells.

“In vivo” amplification of biological activity of tetragastrin by amino acid hydroxamates

1984 ◽  
Vol 4 (12) ◽  
pp. 1009-1015 ◽  
Author(s):  
J. P. Bali ◽  
H. Mattras ◽  
A. Previero ◽  
M. A. Coletti-Previero
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aminopeptidase Activity ◽  
Proteolytic Degradation ◽  
Short Peptides ◽  
Rat Blood ◽  
Active Peptides

Rat blood was shown to contain an aminopeptidase which rapidly hydrolyses short peptides containing an aromatic amino acid as N-terminal residue. Using tetragastrin (Trp-Met-Asp-PheNH 2) as substrate, we showed that some amino acid hydroxamates inhibit rat aminopeptidase activity ‘in vitro’ in the following order: HTrpNHOH > HPheNHOH ≫ HAIaNHOH. The same hydroxamates markedly enhanced the biological activity of tetragastrin ‘in vivo’. The amplification of the secretory effect, correlated with the amount of the hydroxamate used, strongly suggests that these compounds can stabilize a number of active peptides in vivo by inhibiting their proteolytic degradation.

scholarly journals Chlamydia pneumoniaeencodes a functional aromatic amino acid hydroxylase

2009 ◽  
Vol 55 (2) ◽  
pp. 196-205 ◽  
Author(s):  
Stephanie Abromaitis ◽  
P. Scott Hefty ◽  
Richard S. Stephens
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aromatic Amino Acid Hydroxylase

scholarly journals 1120 IN VITRO INHIBITION OF HUMAN PLACENTAL AMINO ACID (A-A) UPTAKE: SYNERGISM BETWEEN NICOTINE (Nic) AND ACETALDEHYDE (AcH)

1981 ◽  
Vol 15 ◽  
pp. 629-629
Author(s):  
Stanley E Fisher ◽  
Mark Atkinson ◽  
Ian Holzman ◽  
David H Van Thiel ◽  
T K Oliver
Keyword(s):  
Amino Acid ◽  
In Vitro Inhibition

In vitro inhibition of the actions of basic FGF by a novel 16 amino acid peptide

1994 ◽  
Vol 130 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Irena Cosic ◽  
Ann E. Drummond ◽  
John R. Underwood ◽  
Milton T. W. Hearn
Keyword(s):  
Amino Acid ◽  
Basic Fgf ◽  
Amino Acid Peptide ◽  
In Vitro Inhibition
Sign in / Sign up

Export Citation Format

Share Document