The different mechanisms of action of nicorandil and adenosine triphosphate on potassium channels of circular smooth muscle of the guinea-pig small intestine

1985 ◽  
Vol 331 (1) ◽  
pp. 96-103 ◽  
Author(s):  
K. Yamanaka ◽  
K. Furukawa ◽  
K. Kitamura
Keyword(s):  
Smooth Muscle ◽  
Small Intestine ◽  
Potassium Channels ◽  
Guinea Pig ◽  
Adenosine Triphosphate ◽  
Mechanisms Of Action ◽  
Circular Smooth Muscle

Presence of functional receptors for corticotropin releasing hormone in caecal circular smooth muscle cells of guinea pig

Life Sciences ◽  
1997 ◽  
Vol 60 (11) ◽  
pp. 857-864 ◽  
Author(s):  
Yuji Iwakiri ◽  
Yoshiharu Chijiiwa ◽  
Yasuaki Motomura ◽  
Mitsuhiro Osame ◽  
Hajime Nawata
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Circular Smooth Muscle

Voltage sensitivity of slow wave frequency in isolated circular muscle strips from guinea pig gastric antrum

1999 ◽  
Vol 276 (2) ◽  
pp. G518-G528 ◽  
Author(s):  
S.-M. Huang ◽  
S. Nakayama ◽  
S. Iino ◽  
T. Tomita
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Slow Wave ◽  
Circular Muscle ◽  
Gastric Antrum ◽  
Slow Waves ◽  
Wave Frequency ◽  
Voltage Sensitivity ◽  
Dependent Manner ◽  
Circular Smooth Muscle

In circular muscle preparations isolated from the guinea pig gastric antrum, regular spontaneous electrical activity (slow waves) was recorded. Under normal conditions (6 mM K+), the frequency and shape of the slow waves were similar to those observed in ordinary stomach smooth muscle preparations. When the resting membrane potential was hyperpolarized and depolarized by changing the extracellular K+ concentration (2–18 mM), the frequency of slow waves decreased and increased, respectively. Application of cromakalim hyperpolarized the cell membrane and reduced the frequency of slow waves in a dose-dependent manner. Cromakalim (3 μM) hyperpolarized the membrane, and slow waves ceased in most preparations. In the presence of cromakalim, subsequent increases in the extracellular K+ concentration restored the frequency of slow waves accompanied by depolarization. Also, glibenclamide completely antagonized this effect of cromakalim. In smooth muscle strips containing both circular and longitudinal muscle layers, such changes in the slow wave frequency were not observed. It was concluded that the maneuver of isolating circular smooth muscle altered the voltage dependence of the slow wave frequency.

Effect of external ions on 45Ca efflux from cat intestinal muscle

1980 ◽  
Vol 238 (6) ◽  
pp. G520-G525
Author(s):  
B. A. Curtis ◽  
D. Kreulen ◽  
C. L. Prosser
Keyword(s):  
Smooth Muscle ◽  
Small Intestine ◽  
Electrical Stimulation ◽  
Membrane Potential ◽  
Ethylene Glycol ◽  
Resting Membrane Potential ◽  
Krebs Solution ◽  
Tetraacetic Acid ◽  
Circular Smooth Muscle ◽  
45Ca Efflux

The surface-bound Ca of isolated circular smooth muscle of cat small intestine can be removed by substitution of LiCl for NaCl in Krebs solution. This substitution removed surface-bound Ca (45Ca) and allowed us to study transmembrane 45Ca efflux. Neither the resting membrane potential nor contractility changed when Li was substituted for Na. Li removed the same extracellular 45Ca store as did ethylene glycol-bis-(beta-aminoethylether)-N,N'-tetraacetic acid. The resting transmembrane 45Ca efflux was inhibited by La3+ and was unchanged in Li, tris(hydroxymethyl)aminomethane, arginine, and sucrose Krebs solution. The extra 45Ca efflux observed upon electrical stimulation was no greater in Na-Krebs than Li-Krebs, but during response to acetylcholine the extra 45Ca efflux was greater in Na-Krebs than Li-Krebs. We conclude that the surface-bound Ca is sensitive to external Na and that the transmembrane Ca efflux is not completely dependent on external Na.

Biochemical and Cytochemical Characterization of Extracellular Proteoglycans in the Inner Circular Smooth Muscle Layer of Dog Small Intestine

IUBMB Life ◽  
2002 ◽  
Vol 54 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Olga Maria Szymanski de Toledo ◽  
Mônica Valéria Marquezini ◽  
Kaio Bin Jia ◽  
Mônica de Campos Pinheiro ◽  
Oswaldo Alves Mora
Keyword(s):  
Smooth Muscle ◽  
Small Intestine ◽  
Muscle Layer ◽  
Smooth Muscle Layer ◽  
Circular Smooth Muscle
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