Effects of prostaglandins F2? and E1 on the longitudinal and circular smooth muscle of the guinea pig caecum in relation to the concentration of extracellular calcium

1975 ◽  
Vol 288 (4) ◽  
pp. 335-343 ◽  
Author(s):  
O. Kadlec ◽  
R. Radomirov
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Extracellular Calcium ◽  
Circular Smooth Muscle

Presence of functional receptors for corticotropin releasing hormone in caecal circular smooth muscle cells of guinea pig

Life Sciences ◽  
1997 ◽  
Vol 60 (11) ◽  
pp. 857-864 ◽  
Author(s):  
Yuji Iwakiri ◽  
Yoshiharu Chijiiwa ◽  
Yasuaki Motomura ◽  
Mitsuhiro Osame ◽  
Hajime Nawata
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Circular Smooth Muscle

Voltage sensitivity of slow wave frequency in isolated circular muscle strips from guinea pig gastric antrum

1999 ◽  
Vol 276 (2) ◽  
pp. G518-G528 ◽  
Author(s):  
S.-M. Huang ◽  
S. Nakayama ◽  
S. Iino ◽  
T. Tomita
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Slow Wave ◽  
Circular Muscle ◽  
Gastric Antrum ◽  
Slow Waves ◽  
Wave Frequency ◽  
Voltage Sensitivity ◽  
Dependent Manner ◽  
Circular Smooth Muscle

In circular muscle preparations isolated from the guinea pig gastric antrum, regular spontaneous electrical activity (slow waves) was recorded. Under normal conditions (6 mM K+), the frequency and shape of the slow waves were similar to those observed in ordinary stomach smooth muscle preparations. When the resting membrane potential was hyperpolarized and depolarized by changing the extracellular K+ concentration (2–18 mM), the frequency of slow waves decreased and increased, respectively. Application of cromakalim hyperpolarized the cell membrane and reduced the frequency of slow waves in a dose-dependent manner. Cromakalim (3 μM) hyperpolarized the membrane, and slow waves ceased in most preparations. In the presence of cromakalim, subsequent increases in the extracellular K+ concentration restored the frequency of slow waves accompanied by depolarization. Also, glibenclamide completely antagonized this effect of cromakalim. In smooth muscle strips containing both circular and longitudinal muscle layers, such changes in the slow wave frequency were not observed. It was concluded that the maneuver of isolating circular smooth muscle altered the voltage dependence of the slow wave frequency.

scholarly journals Modification by charybdotoxin and apamin of spontaneous electrical and mechanical activity of the circular smooth muscle of the guinea-pig stomach

1993 ◽  
Vol 109 (3) ◽  
pp. 661-666 ◽  
Author(s):  
Keiko Suzuki ◽  
Kaoru M. Ito ◽  
Yukie Minayoshi ◽  
Hikaru Suzuki ◽  
Masahisa Asano ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Mechanical Activity ◽  
Circular Smooth Muscle ◽  
Guinea Pig Stomach
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