Fine structural localization of thiamine pyrophosphatase and acid phosphatase activities in the mouse pancreatic acinar cell

1979 ◽  
Vol 64 (3) ◽  
pp. 287-295 ◽  
Author(s):  
H. Fujita ◽  
H. Okamoto
Keyword(s):  
Acid Phosphatase ◽  
Acinar Cell ◽  
Pancreatic Acinar Cell ◽  
Structural Localization ◽  
Phosphatase Activities ◽  
Thiamine Pyrophosphatase

Histopathology of pancreatic acinar cell metaplasia in Barrett's esophagus

2006 ◽  
Vol 44 (05) ◽  
Author(s):  
L Tiszlavicz ◽  
I Németh ◽  
A Rosztóczy ◽  
F Izbéki ◽  
Z F. Kiss ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Acinar Cell ◽  
Barrett's Esophagus ◽  
Pancreatic Acinar Cell

scholarly journals Early changes in pancreatic acinar cell calcium signaling after pancreatic duct obstruction.

2003 ◽  
Vol 278 (17) ◽  
pp. 15456
Author(s):  
Frank Ch. Mooren ◽  
Verena Hlouschek ◽  
Till Finkes ◽  
Stefan Turi ◽  
Ina Alexandra Weber ◽  
...  
Keyword(s):  
Calcium Signaling ◽  
Pancreatic Duct ◽  
Acinar Cell ◽  
Pancreatic Acinar Cell ◽  
Duct Obstruction ◽  
Cell Calcium ◽  
Pancreatic Duct Obstruction

Cushing’s Syndrome in a Child with Pancreatic Acinar Cell Carcinoma

2007 ◽  
Vol 18 (2) ◽  
pp. 95-102 ◽  
Author(s):  
György Illyés ◽  
Andrea Luczay ◽  
Gábor Benyó ◽  
Attila Kálmán ◽  
Katalin Borka ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Acinar Cell ◽  
Cushing’S Syndrome ◽  
Acinar Cell Carcinoma ◽  
Cushing's Syndrome ◽  
Pancreatic Acinar Cell ◽  
Pancreatic Acinar Cell Carcinoma

Effect of IS-741 on ethionine-induced acute pancreatitis in rats: relation to pancreatic acinar cell regeneration

2003 ◽  
Vol 38 (3) ◽  
pp. 260-267 ◽  
Author(s):  
Tsunao Imamura ◽  
Junichi Niikawa ◽  
Katsuya Kitamura ◽  
Akira Takahashi ◽  
Akitoshi Ikegami ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Acinar Cell ◽  
Pancreatic Acinar Cell ◽  
Cell Regeneration

Stimulation of stellate cells by injured acinar cells: a model of acute pancreatitis induced by alcohol and fat (VLDL)

2009 ◽  
Vol 297 (6) ◽  
pp. G1163-G1171 ◽  
Author(s):  
Marco Siech ◽  
Zhengfei Zhou ◽  
Shaoxia Zhou ◽  
Bernd Bair ◽  
Andreas Alt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Pancreatitis ◽  
Acinar Cell ◽  
Cell Injury ◽  
Stellate Cell ◽  
Stellate Cells ◽  
Pancreatic Acinar Cell ◽  
Pancreatic Stellate Cells ◽  
Matrix Synthesis ◽  
Repair Mechanisms

Mechanisms leading to acute pancreatitis after a fat-enriched meal combined with excess alcohol are incompletely understood. We have studied the effects of alcohol and fat (VLDL) on pancreatic acinar cell (PAC) function, oxidative stress, and repair mechanisms by pancreatic stellate cells (PSC) leading to fibrogenesis. To do so, PAC (rat) were isolated and cultured up to 24 h. Ethanol and/or VLDL were added to PAC. We measured PAC function (amylase, lipase), injury (lactic dehydrogenase), apoptosis (TUNEL, Apo2.7, annexin V binding), oxidative stress, and lipid peroxidation (conjugated dienes, malondialdehyde, chemoluminescence); we also measured PSC proliferation (bromodeoxyuridine incorporation), matrix synthesis (immunofluorescence of collagens and fibronectin, fibronectin immunoassay), and fatty acids in PAC supernatants (gas chromatography). Within 6 h, cultured PAC degraded and hydrolyzed VLDL completely. VLDL alone (50 μg/ml) and in combination with alcohol (0.2, 0.5, and 1% vol/vol) induced PAC injury (LDL, amylase, and lipase release) within 2 h through generation of oxidative stress. Depending on the dose of VLDL and alcohol, apoptosis and/or necrosis were induced. Antioxidants (Trolox, Probucol) reduced the cytotoxic effect of alcohol and VLDL. Supernatants of alcohol/VLDL-treated PAC stimulated stellate cell proliferation and extracellular matrix synthesis. We concluded that, in the presence of lipoproteins, alcohol induces acinar cell injury. Our results provide a biochemical pathway for the clinical observation that a fat-enriched meal combined with excess alcohol consumption can induce acinar cell injury (acute pancreatitis) followed by repair mechanisms (proliferation and increased matrix synthesis in PSC).

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