Cell population density and phenotypic expression of tissue culture fibroblasts from heterozygotes of Lesch-Nyhan's disease (inosinate pyrophosphorylase deficiency)

1969 ◽  
Vol 3 (6) ◽  
pp. 609-615 ◽  
Author(s):  
Joseph Dancis ◽  
Rody P. Cox ◽  
Peter H. Berman ◽  
Valerie Jansen ◽  
M. Earl Balis
1975 ◽  
Vol 67 (3) ◽  
pp. 518-522 ◽  
Author(s):  
I L Cameron ◽  
N C Bols

The ciliated protozoan, Tetrahymena pyriformis strain GL-C, has been used to study the effect of cell population density during starvation on the synchrony obtained after refeeding and on the number of cells arrested in G2 phase of the cell cycle. At high cell densities two peaks of division indices were observed after refeeding while only one was observed at low cell densities. Cell division began earlier in cultures starved at high cell densities. Most importantly, the proportion of cells in G2 was considerably higher in populations starved at high cell densities. When tritiated thymidine was present during the refeeding period, radioautographs of cell samples at different times showed that the first cells to exhibit division furrows contained unlabeled nuclei. The first peak in the division index after refeeding was observed only at higher cell densities and is attributed to the cells arrested in G2. These results suggest that Tetrahymena is an excellent organism to study the concept of resting stages in the cell cycle and their control.


2008 ◽  
Vol 288 (1) ◽  
pp. 25-32 ◽  
Author(s):  
María Teresa Morán-Zorzano ◽  
Manuel Montero ◽  
Francisco José Muñoz ◽  
Nora Alonso-Casajús ◽  
Alejandro Miguel Viale ◽  
...  

2006 ◽  
Vol 142 (2) ◽  
pp. 696-709 ◽  
Author(s):  
Anna Beňová-Kákošová ◽  
Catherine Digonnet ◽  
Florence Goubet ◽  
Philippe Ranocha ◽  
Alain Jauneau ◽  
...  

1975 ◽  
Vol 84 (1) ◽  
pp. 25-35 ◽  
Author(s):  
G. R. F. Krueger ◽  
H. -E. Schaefer ◽  
J. Luetzeler ◽  
R. Fischer ◽  
V. Kresin

1978 ◽  
Vol 172 (1) ◽  
pp. 181-184 ◽  
Author(s):  
M Gacto

The incorporation of radioactively labelled fucose into the lipid fraction of cultured normal human cells and several human tumour-cell lines was examined as a function of the cell population density. Normal cells exhibited a density-dependent pattern of incorporation, whereas in tumour cells the radioactivity incorporated was independent of the cell population density. An exception was found among the tumour cells, which suggests a possible correlation between the loss of this marker and the ability to produce tumours.


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