Spontaneous variations in the cell population of a T-cell lymphoma during tissue culture and transplantation

1975 ◽  
Vol 84 (1) ◽  
pp. 25-35 ◽  
Author(s):  
G. R. F. Krueger ◽  
H. -E. Schaefer ◽  
J. Luetzeler ◽  
R. Fischer ◽  
V. Kresin
Keyword(s):  
Tissue Culture ◽  
T Cell ◽  
Cell Population ◽  
Cell Lymphoma ◽  
T Cell Lymphoma

Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10

Blood ◽  
2002 ◽  
Vol 99 (2) ◽  
pp. 627-633 ◽  
Author(s):  
Ayoma Attygalle ◽  
Rajai Al-Jehani ◽  
Tim C. Diss ◽  
Phillipa Munson ◽  
Hongxiang Liu ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Population ◽  
Cell Lymphoma ◽  
Single Cells ◽  
Systemic Disease ◽  
T Cell Lymphoma ◽  
Chain Gene ◽  
Reactive Lymphoid Hyperplasia ◽  
Angioimmunoblastic T Cell Lymphoma

Abstract Angioimmunoblastic T-cell lymphoma (AITL) is a systemic disease involving lymph nodes, spleen, and bone marrow. Although the histologic features have been well described, the diagnosis is often challenging, as there are no specific phenotypic or molecular markers available. This study shows that the neoplastic cells of AITL can be identified by aberrant CD10 expression. Archival material from 30 cases of AITL, 10 cases of peripheral T-cell lymphoma unspecified (PTL), and 10 cases of reactive lymphoid hyperplasia were reviewed. Single and double immunostaining for CD3, CD4, CD8, CD20, CD21, CD10, BCL6, Ki67, and LMP-1 in situ hybridization for Epstein-Barr early region and polymerase chain reaction (PCR) for T-cell receptor gamma chain gene and immunoglobulin heavy chain gene were performed. Three overlapping histologic patterns with hyperplastic follicles, depleted follicles, or without follicles were identified in AITL. Of the 30 cases of AITL, 27 contained CD10+ T cells. No CD10+ T cells were present in the cases of PTL or reactive hyperplasia. PCR confirmed a monoclonal or oligoclonal T-cell population in 29 of 30 cases of AITL and a monoclonal B-cell population in 6 cases. Analysis of microdissected CD10+ single cells showed that they belonged to the neoplastic clone. In conclusion CD10 is a phenotypic marker that specifically identifies the tumor cells in 90% of AITL, including the early cases. The presence of these cells distinguishes AITL from other PTLs. This finding provides an objective criterion for accurate and early diagnosis of AITL.

scholarly journals IL-31 Is Produced by the Malignant T-Cell Population in Cutaneous T-Cell Lymphoma and Correlates with CTCL Pruritus

2013 ◽  
Vol 133 (12) ◽  
pp. 2783-2785 ◽  
Author(s):  
Elisha M. Singer ◽  
Daniel B. Shin ◽  
Leigh A. Nattkemper ◽  
Bernice M. Benoit ◽  
Rachel S. Klein ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Population ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma

scholarly journals Functional Inhibitory Receptors Expressed by a Cutaneous T Cell Lymphoma-Specific Cytolytic Clonal T Cell Population

2000 ◽  
Vol 115 (6) ◽  
pp. 994-999 ◽  
Author(s):  
Martine Bagot ◽  
Denis Martinvallet ◽  
Hamid Echchakir ◽  
Fabienne Chabanette-Schirm ◽  
Laurence Boumsell ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Population ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Inhibitory Receptors

Mucosal Intra-epithelial Lymphocytes in Enteropathy-Associated T-Cell Lymphoma, Ulcerative Jejunitis, and Refractory Celiac Disease Constitute a Neoplastic Population

Blood ◽  
1999 ◽  
Vol 94 (1) ◽  
pp. 260-264 ◽  
Author(s):  
Eniko Bagdi ◽  
Timothy C. Diss ◽  
Philippa Munson ◽  
Peter G. Isaacson
Keyword(s):  
Celiac Disease ◽  
T Cell ◽  
Cell Population ◽  
Cell Lymphoma ◽  
Treatment Strategies ◽  
T Cell Lymphoma ◽  
Refractory Celiac Disease ◽  
Clonal Identity ◽  
Refractory Sprue ◽  
Ulcerative Jejunitis

Loss of response to a gluten-free diet (refractory sprue) and ulcerative jejunitis are complications of celiac disease that may progress to enteropathy-associated T-cell lymphoma (EATL). Both conditions are characterized by the presence of a nonlymphomatous monoclonal T-cell population in the enteropathic mucosa. In EATL, a similar monoclonal population that shows clonal identity with the lymphoma itself is also present in the enteropathic mucosa. In this study we show that in all three circumstances the monoclonal T-cell population is constituted by cytologically normal, noninvasive intraepithelial T lymphocytes that share an identical aberrant immunophenotype with EATL. Patients with refractory sprue and/or ulcerative jejunitis are, therefore, suffering from a neoplastic T-cell disorder for which hematological treatment strategies need to be devised.

Sign in / Sign up

Export Citation Format

Share Document