Experimental burn-induced changes in lipid peroxide levels, and activity of superoxide dismutase and glutathione peroxidase in skin lesions, serum, and liver of mice

1988 ◽  
Vol 280 (3) ◽  
pp. 171-175 ◽  
Author(s):  
S. Kawai ◽  
J. Komura ◽  
Y. Asada ◽  
Y. Niwa
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Lipid Peroxide ◽  
Skin Lesions ◽  
Experimental Burn ◽  
Induced Changes

Control of superoxide dismutase, catalase and glutathione peroxidase activities in rat lymphoid organs by thyroid hormones

1994 ◽  
Vol 140 (1) ◽  
pp. 73-77 ◽  
Author(s):  
B Pereira ◽  
L F B P Costa Rosa ◽  
D A Safi ◽  
E J H Bechara ◽  
R Curi
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Thyroid Hormones ◽  
Citrate Synthase ◽  
Lipid Peroxide ◽  
Lymphoid Organs ◽  
Mesenteric Lymph Nodes ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Reducing Equivalents

Abstract This study examined the effect of experimental hyperand hypothyroidism on the superoxide dismutase, catalase and glutathione peroxidase activities of rat lymphoid organs (mesenteric lymph nodes, spleen and thymus) and muscles (soleus and gastrocnemius-white portion) for comparison. The capacity for the generation of reducing equivalents was also investigated: activities of glucose-6-phosphate dehydrogenase (pentose-phosphate pathway) and citrate synthase (Krebs cycle). Hyperthyroidism tended to enhance lipid peroxide content in all tissues. This effect may result from (1) a high capacity for the generation of reducing equivalents in cytosol and mitochondria and (2) a reduced activity of catalase in the lymphoid organs and of glutathione peroxidase in the muscles. The process of lipid peroxidation in these tissues caused by hyperthyroidism was probably slowed down by the augmentation of CuZn- and Mn-superoxide dismutase (Mn-SOD) activities observed under this condition. Hypothyroidism tended to diminish lipid peroxidation and did not affect citrate synthase and glucose-6-phosphate dehydrogenase activities in the lymphoid organs and muscles. Low levels of thyroid hormones tended to diminish Mn-SOD and glutathione peroxidase activities. These findings show that the thyroid hormones might be able to regulate the activities of CuZn- and Mn-SOD, and catalase and glutathione peroxidase in the lymphoid organs and skeletal muscles. Journal of Endocrinology (1994) 140, 73–77

Serum lipid peroxide levels and erythrocyte glutathione peroxidase and superoxide dismutase activity in premenopausal and postmenopausal women

2001 ◽  
Vol 15 (4) ◽  
pp. 298-303 ◽  
Author(s):  
G. Bednarek-Tupikowska ◽  
A. Bohdanowicz-Pawlak ◽  
B. Bidzinska ◽  
A. Milewicz ◽  
J. Antonowicz-Juchniewicz ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Postmenopausal Women ◽  
Serum Lipid ◽  
Lipid Peroxide ◽  
Superoxide Dismutase Activity ◽  
Serum Lipid Peroxide

scholarly journals Influence of chromium citrate on oxidative stress in the tissues of muscle and kidney of rats with experimentally induced diabetes

2019 ◽  
Vol 10 (2) ◽  
pp. 209-214
Author(s):  
О. О. Sushko ◽  
R. J. Iskra ◽  
L. I. Ponkalo
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Skeletal Muscles ◽  
Reduced Glutathione ◽  
Lipid Peroxide ◽  
Diabetic Rats ◽  
Lipid Hydroperoxides ◽  
Peroxide Oxidation ◽  
Glucose Levels

Chromium is one of the important trace elements that is essential for carbohydrate, protein and lipid metabolism. Chromium improves glucose metabolism and reduces insulin resistance due to increased insulin sensitivity. Therefore, it is important to consider the use of chromium citrate as a nutritional supplement with potential hypoglycemic and hypolipidemic effects. In this research work, we investigated the activity of the antioxidant system and the level of lipid hydroperoxides in the tissues of skeletal muscles and kidneys of experimental diabetic rats and for rats which received in their daily diet chromium citrate in the amounts 0.1 and 0.2 μg/mL of water. We induced the experimental model of diabetes by intraperitoneal injection of alloxan in the amount 150 mg/kg of body weight of the animals. We monitored glucose levels by measuring daily glucose levels with a portable glucose meter. For research, we selected animals with a glucose level > 11.1 mmol/L. We monitored the body weight of rats. On the 40th day of the study, we withdrew the animals from the experiment by decapitation. We selected the tissue for research, namely skeletal muscles and kidneys. In samples of the tissue homogenates, we measured the activity of antioxidant enzymes and the content of lipid peroxide oxidation products. As a result of our research, we found that the products of lipid peroxide oxidation and glutathione peroxidase activity increased in skeletal muscle of animals with diabetes mellitus. The activity of glutathione reductase, catalase, superoxide dismutase, and the content of reduced glutathione decreased at the same time. In the kidneys of diabetic rats, the activity of glutathione peroxidase, glutathione reductase, catalase and content of lipid hydroperoxides increased but the activity of superoxide dismutase and the content of reduced glutathione decreased. The addition of chromium citrate to the diet of animals in amounts 0.1 and 0.2 μg/mL led to the suppression of oxidative stress. The activity of catalase, glutathione peroxidase and the content of lipid hydroperoxides, TBA-positive substances decreased. Also, the activity of superoxide dismutase increased with the addition of chromium citrate. These results indicate normalization of antioxidant defense in the skeletal muscle and kidneys of experimental rats with experimental diabetes given chromium citrate in the amount 0.1 mg/mL of water.

Time Course Study of Oxidative Stress in Aorta and Heart of Diabetic Rat

1996 ◽  
Vol 91 (4) ◽  
pp. 441-448 ◽  
Author(s):  
Rakesh Kakkar ◽  
Subrahmanyam V. Mantha ◽  
Jawahar Kalra ◽  
Kailash Prasad
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Lipid Peroxide ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Control Group ◽  
Contributory Factor ◽  
Time Intervals

1. Oxygen free radicals have been suggested to be a contributory factor in complications of diabetes mellitus. In the present study, we investigated the lipid peroxide level [thiobarbituric acid-reactive substances (TBARS)] and activities of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) in aorta, heart and blood of control and streptozotocin-induced diabetic rats at various stages of development of diabetes (0 to 6 weeks). 2. There was no change in the TBARS levels of aorta, heart and blood in the control group. A significant (P < 0.05) increase in TBARS levels of aorta, heart and blood was observed in the diabetic group. 3. There were no significant changes in the activities of superoxide dismutase, catalase and glutathione peroxidase in the aorta, heart and blood of control rats at all time intervals. In the diabetic group, there was a significant (P < 0.05) increase in the activity of superoxide dismutase and glutathione peroxidase in aorta from the fourth week onwards while the activity of catalase increased at all time intervals. In the heart of diabetic rats, the activity of total superoxide dismutase and Cu—Zn-superoxide dismutase increased significantly (P < 0.05) from the second week onwards while activity of Mn-superoxide dismutase decreased at the fourth week and increased at the sixth week. The activity of catalase and glutathione peroxidase increased significantly (P < 0.05) at all time intervals. In the blood, the activity of superoxide dismutase and glutathione peroxidase increased from the third week while catalase activity increased from the fourth week. 4. The present findings suggest that oxidative stress starts at early onset of diabetes mellitus and increases progressively.

Serum lipid peroxide levels and erythrocyte glutathione peroxidase and superoxide dismutase activity in premenopausal and postmenopausal women

2001 ◽  
Vol 15 (4) ◽  
pp. 298-303 ◽  
Author(s):  
G. Bednarek-Tupikowska ◽  
A. Bohdanowicz-Pawlak ◽  
B. Bidzińska ◽  
A. Milewicz ◽  
J. Antonowicz-Juchniewicz ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Postmenopausal Women ◽  
Serum Lipid ◽  
Lipid Peroxide ◽  
Superoxide Dismutase Activity ◽  
Serum Lipid Peroxide
Sign in / Sign up

Export Citation Format

Share Document