Idiopathic hair cell loss in the guinea pig

1978 ◽  
Vol 221 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Libuše Úlehlová ◽  
L. Voldřich
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Cell Loss ◽  
Hair Cell Loss

Hair Cell Loss in the Aged Guinea Pig Cochlea

1999 ◽  
Vol 119 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Neil J. Ingham, Spiro D. Comis, Deb
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Guinea Pig Cochlea

Permanent Threshold Shift and Cochlear Hair Cell Loss in the Kanamycin-Treated Guinea Pig

1978 ◽  
Vol 86 (6) ◽  
pp. ORL-886-ORL-887 ◽  
Author(s):  
Cynthia A. Prosen ◽  
Michael R. Petersen ◽  
David. B. Moody ◽  
William C. Stebbins ◽  
Joseph E. Hawkins
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Hair Cells ◽  
Guinea Pigs ◽  
Cell Loss ◽  
Outer Hair Cells ◽  
Hair Cell Loss ◽  
Hearing Sensitivity ◽  
Cochlear Hair Cell ◽  
Differential Contribution

The differential contribution of the inner hair cells (IHC) and the outer hair cells (OHC) in the mammalian cochlea to hearing sensitivity was assessed in six behaviorally-trained guinea pigs by comparing audiograms preadministration and postadministration of kanamycin, an antibiotic that predominantly destroys guinea pig OHC while leaving the IHC structurally unchanged. The results support the hypothesis that only the IHC of the cochlea responds to tones approximately 50 to 60 dB above the threshold of the intact cochlea.

Quercetin protects against hair cell loss in the zebrafish lateral line and guinea pig cochlea

2016 ◽  
Vol 342 ◽  
pp. 80-85 ◽  
Author(s):  
Yoshinobu Hirose ◽  
Kazuma Sugahara ◽  
Eiju Kanagawa ◽  
Yousuke Takemoto ◽  
Makoto Hashimoto ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Lateral Line ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Guinea Pig Cochlea

Chronic Perilymphatic Fistula: Experimental Model in the Guinea Pig

1988 ◽  
Vol 99 (4) ◽  
pp. 380-388 ◽  
Author(s):  
Paul Flint ◽  
Larry G. Duckert ◽  
Robert A. Dobie ◽  
Edwin W. Rubel
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Round Window ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Scala Tympani ◽  
Rubber Tubing ◽  
Perilymphatic Fistula ◽  
Similar Threshold ◽  
Baseline Levels

Chronic perilymphatic fistulas were created in guinea pig cochleas using silicone rubber tubing placed into the scala tympani through the round window. Fistula patency was determined by fluorescein perfusion into cerebral spinal fluid. Fistulas were found to be patent in 6 of 6 animals at 7 days and 8 of 13 animals at 28 days. Analysis of ABRs revealed threshold increases of 10 to 15 dB across all frequencies at 1 hour and 7 days. However, thresholds returned to pre-fistula levels by 28 days. Animals with acute fistulas (simple laceration of the round window) had similar threshold increases at 1 hour; however, recovery to baseline levels occurred by day 7. Control animals with intact round windows did not have threshold shifts. Scanning electron microscopy revealed hair cell loss localized to the apical and basal turns of the cochlea. The morphologic changes observed occurred acutely (within 7 days) and were not progressive, despite the presence of a fistula. Hair cell loss or degeneration did not correlate with hearing loss.

scholarly journals Alteration of Musashi1 Intra-cellular Distribution During Regeneration Following Gentamicin-Induced Hair Cell Loss in the Guinea Pig Crista Ampullaris

2019 ◽  
Vol 13 ◽  
Author(s):  
Makoto Kinoshita ◽  
Chisato Fujimoto ◽  
Shinichi Iwasaki ◽  
Akinori Kashio ◽  
Yayoi S. Kikkawa ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Cell Loss ◽  
Cellular Distribution ◽  
Hair Cell Loss ◽  
Crista Ampullaris
Sign in / Sign up

Export Citation Format

Share Document