Hyperplastic and metaplastic lesions in the reproductive tract of male rats induced by neonatal treatment with diethylstilbestrol

1977 ◽  
Vol 376 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Yasumasa Arai ◽  
Yoshihide Suzuki ◽  
Yasuaki Nishizuka
Keyword(s):  
Reproductive Tract ◽  
Male Rats ◽  
Neonatal Treatment

scholarly journals Altered sexual differentiation of hepatic uridine diphosphate glucuronyltransferase by neonatal hormone treatment in rats

1979 ◽  
Vol 180 (2) ◽  
pp. 313-318 ◽  
Author(s):  
Coral A. Lamartiniere ◽  
Cindy S. Dieringer ◽  
Etsuko Kita ◽  
George W. Lucier
Keyword(s):  
Enzyme Activity ◽  
Adult Male ◽  
Sexual Differentiation ◽  
Reproductive Tract ◽  
Testosterone Propionate ◽  
Hormone Treatment ◽  
Male Rats ◽  
Ventral Prostate ◽  
Uridine Diphosphate ◽  
Neonatal Administration

The hepatic microsomal enzyme UDP-glucuronyltransferase undergoes a complex developmental pattern in which enzyme activity is first detectable on the 18th day of gestation in rats. Prepubertal activities are similar for males and females. However, postpubertal sexual differentiation of enzyme activity occurs in which male activities are twice those of females. Neonatal administration of testosterone propionate or diethylstilboestrol to intact animals resulted in lowered UDP-glucuronyltransferase activity in liver microsomal fractions of adult male rats, whereas no changes were observed in the adult females and prepubertal male and female animals. Neonatal administration of testosterone propionate and diethylstilboestrol adversely affected male reproductive-tract development as evidenced by decreased weights of testes, seminal vesicles and ventral prostate. Diethylstilboestrol also markedly decreased spermatogenesis. Hypophysectomy of adult male rats resulted in negative modulation of microsomal UDP-glucuronyltransferase and prevented the sexual differentiation of enzyme activity. In contrast hypophysectomy had no effect on female UDP-glucuronyltransferase activity. A pituitary transplant under the kidney capsule was not capable of reversing the enzyme effects of hypophysectomy, therefore suggesting that the male pituitary factor(s) responsible for positive modulation of UDP-glucuronyltransferase might be under hypothalamic control in the form of a releasing factor. Neonatal testosterone propionate and diethylstilboestrol administration apparently interfered with the normal sequence of postpubertal UDP-glucuronyltransferase sexual differentiation.

The neonatal treatment with clomipramine decreases sexual motivation and increases estrogen receptors expression in the septum of male rats: Effects of the apomorphine

2019 ◽  
Vol 180 ◽  
pp. 83-91 ◽  
Author(s):  
Tania Molina-Jiménez ◽  
Martín Jiménez-Tlapa ◽  
Malinalli Brianza-Padilla ◽  
Rossana Citlali Zepeda ◽  
Marisela Hernández-González ◽  
...  
Keyword(s):  
Estrogen Receptors ◽  
Sexual Motivation ◽  
Male Rats ◽  
Neonatal Treatment

Reproductive tract lesions resulting from subchronic administration (63 days) of tri-o-cresyl phosphate in male rats

1987 ◽  
Vol 89 (1) ◽  
pp. 49-63 ◽  
Author(s):  
Stephen G. Somkuti ◽  
Daniel M. Lapadula ◽  
Robert E. Chapin ◽  
James C. Lamb ◽  
Mohamed B. Abou-Donia
Keyword(s):  
Reproductive Tract ◽  
Male Rats

scholarly journals Phthalate-induced pathology in the foetal testis involves more than decreased testosterone production

Reproduction ◽  
2014 ◽  
Vol 147 (4) ◽  
pp. 435-442 ◽  
Author(s):  
D N Rao Veeramachaneni ◽  
Gary R Klinefelter
Keyword(s):  
Reproductive Tract ◽  
Comprehensive Evaluation ◽  
Male Rats ◽  
Testicular Dysgenesis Syndrome ◽  
Pathway Network ◽  
New Findings ◽  
Testicular Dysgenesis ◽  
And Migration ◽  
And Function ◽  
Rats And Mice

Foetal exposure to phthalates is known to adversely impact male reproductive development and function. Developmental anomalies of reproductive tract have been attributed to impaired testosterone synthesis. However, species differences in the ability to produce testosterone have been noted; e.g., following foetal exposure, abnormal clustering of Leydig cells or decreased production of testosterone that is manifested in rats does not occur in mice or humans. Nonetheless, other facets of testicular dysgenesis occur in both rats and mice as well as in some other species tested. We recently published a comprehensive evaluation of the foetal rat testis proteome, following in utero exposure to diethylhexyl phthalate (DEHP), which revealed changes in individual proteins that are known to be factors in cellular differentiation and migration or related to the capacity of the foetal Leydig cell to produce testosterone and fit a pathway network in which each is regulated directly or indirectly by oestradiol. Plasma oestradiol indeed was found to be elevated approximately twofold in 19-day-old DEHP-exposed foetal male rats. In this brief review, we discuss our new findings vis-à-vis ‘oestrogen hypothesis’ as a cause for testicular dysgenesis syndrome.

scholarly journals Neonatal Coadministration of Testosterone With Diethylstilbestrol Prevents Diethylstilbestrol Induction of Most Reproductive Tract Abnormalities in Male Rats

2003 ◽  
Vol 24 (4) ◽  
pp. 557-567 ◽  
Author(s):  
Ana Rivas ◽  
Chris McKinnell ◽  
Jane S. Fisher ◽  
Nina Atanassova ◽  
Karin Williams ◽  
...  
Keyword(s):  
Reproductive Tract ◽  
Male Rats

The Effect of Diabetes on Sexual Behavior and Reproductive Tract Function in Male Rats

1993 ◽  
Vol 149 (1) ◽  
pp. 148-154 ◽  
Author(s):  
Ayman A. Hassan ◽  
Magdy M. Hassouna ◽  
Teruko Taketo ◽  
Claude Gagnon ◽  
Mostafa M. Elhilali
Keyword(s):  
Sexual Behavior ◽  
Reproductive Tract ◽  
Male Rats ◽  
Tract Function

Effects of pomegranate peel extract on the reproductive tract complications of sodium selenite in immature male rats

2020 ◽  
Vol 7 (1) ◽  
pp. 6
Author(s):  
Asghar Mogheiseh ◽  
Fatemeh Namazi ◽  
Mahboobeh Ashrafi ◽  
Esmaeil Bandariyan ◽  
Arash Rakhshi-Asl ◽  
...  
Keyword(s):  
Sodium Selenite ◽  
Reproductive Tract ◽  
Male Rats ◽  
Pomegranate Peel ◽  
Immature Male ◽  
Pomegranate Peel Extract ◽  
Peel Extract
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