scholarly journals Diurnal variation in the effects of insulin on blood glucose, plasma non-esterified fatty acids and growth hormone

Diabetologia ◽  
1975 ◽  
Vol 11 (1) ◽  
pp. 83-88 ◽  
Author(s):  
T. Gibson ◽  
L. Stimmler ◽  
R. J. Jarrett ◽  
P. Rutland ◽  
M. Shiu
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Blood Glucose ◽  
Diurnal Variation ◽  
Esterified Fatty Acids ◽  
Glucose Plasma

CERTAIN BLOOD CONSTITUENTS OF A LIZARD DURING HIBERNATION AND ACTIVITY

1967 ◽  
Vol 45 (1) ◽  
pp. 115-119 ◽  
Author(s):  
M. Zain-ul-Abedin ◽  
B. Katorski
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Plasma Protein ◽  
Plasma Nefa ◽  
Nonprotein Nitrogen ◽  
Nonesterified Fatty Acids ◽  
Blood Constituents ◽  
Protein Levels ◽  
Esterified Fatty Acids ◽  
Glucose Plasma

Blood glucose, plasma nonesterified fatty acids (NEFA), plasma esterified fatty acids (EFA), plasma protein, and blood nonprotein nitrogen (NPN) were measured in a lizard, Uromastix hardwickii, both during activity and hibernation. In hibernating lizards the blood glucose and plasma protein levels were unaltered, plasma NEFA and EFA almost doubled, and the NPN of the protein-free filtrate prepared with trichloroacetic acid was decreased by 15%, whereas that determined on the zinc sulfate – sodium hydroxide filtrate was unaltered. These findings are discussed in relation to possible energy sources during hibernation and the transport of lipids to abdominal fat: pads.

Effect of somatostatin on blood glucose, plasma growth hormone, insulin, and free fatty acids in normal subjects and acromegalic patients

Metabolism ◽  
1974 ◽  
Vol 23 (11) ◽  
pp. 1009-1015 ◽  
Author(s):  
M. Peracchi ◽  
E. Reschini ◽  
L. Cantalamessa ◽  
G. Giustina ◽  
F. Cavagnini ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Normal Subjects ◽  
Plasma Growth Hormone ◽  
Glucose Plasma

Effects of growth hormone-releasing factors and cottonseed meal on hormones and metabolites in plasma from lambs fed lucerne chaff ad libitum

1994 ◽  
Vol 45 (6) ◽  
pp. 1125 ◽  
Author(s):  
RD Sainz ◽  
BJ Hosking ◽  
FJ Hart ◽  
GSG Spencer
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Growth Factor ◽  
Cottonseed Meal ◽  
Metabolic Effects ◽  
Insulin Like Growth Factor ◽  
Plasma Urea ◽  
Blood Samples ◽  
Esterified Fatty Acids ◽  
Ad Libitum

This study was part of an experiment on the effects of cottonseed meal (CSM) and growth hormone-releasing factor (GRF) on growth in lambs fed lucerne chaff. Forty-eight crossbred lambs were fed lucerne chaff ad libitum, alone or with a cottonseed meal supplement (CSM; 300 g/day). Eight lambs from each group were injected twice daily with recombinant or synthetic GRF (rGRF and sGRF respectively; 30 8g per kg body weight/day) or excipient only for 28 or 30 days. Jugular blood samples were obtained on days 0, 7, 14, 21 and 28. On day 29, blood samples were taken from selected lambs (n = 2/group) at 0, 20, 40, 60, 80, 100, 120, 160 and 240 min after injection. Supplementation of lucerne chaff with CSM generally increased glucose and urea concentrations in plasma, reflecting improved energy and protein status. However, concentrations of growth hormone, insulin-like growth factor-1 and insulin were unaffected by CSM, as were plasma proteins, triacylglycerols and non-esterified fatty acids. Injection of rGRF and sGRF stimulated secretion of growth hormone (GH), insulin-like growth factor-1 (IGF-1) and insulin. Peak GH concentrations (20 min) following injection of GRF appeared to be higher in lambs fed CSM than in those receiving lucerne chaff alone. In contrast, maximal concentrations of IGF-1 were seen after 14 days of treatment. These changes were accompanied by increased plasma glucose, with no changes in triacylglycerols, non-esterified fatty acids and protein. Plasma urea was reduced by GRF, indicating that amino acids were diverted away from catabolism towards protein synthesis. These two sources of GRF were very similar in their endocrine and metabolic effects. This confirms similar observations regarding their effects on growth performance and carcass composition.

THE DIAGNOSIS OF HYPOPITUITARISM WITH SPECIAL REFERENCE TO THE ESTIMATION OF PLASMA NON-ESTERIFIED FATTY ACIDS

1970 ◽  
Vol 46 (2) ◽  
pp. 167-175 ◽  
Author(s):  
R. WILKINSON ◽  
R. HALL ◽  
A. COOPER ◽  
D. J. NEWELL
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
No Value ◽  
Insulin Injection ◽  
Thyroid Stimulating Hormone ◽  
Adrenocorticotrophic Hormone ◽  
Plasma Nefa ◽  
Esterified Fatty Acids ◽  
Significant Impairment ◽  
Sugar Levels

SUMMARY Plasma non-esterified fatty acid (NEFA) levels during a standard insulin sensitivity test have been compared in hypopituitary and hospital control patients who had undergone full routine pituitary investigations. Significant impairment of the recovery of plasma NEFA levels after insulin injection was found in the hypopituitary group as a whole, but this finding was not consistent in individual cases. It is concluded that the measurement of NEFA levels is of little value in the diagnosis of mild hypopituitarism. Blood sugar levels after insulin were of no value in the diagnosis of minor degrees of hypopituitarism. In 19 patients with mild hypopituitarism the order of frequency of deficiency of individual hormones, as judged by tests currently available, was gonadotrophins followed by growth hormone, adrenocorticotrophic hormone, thyroid-stimulating hormone, and antidiuretic hormone.

Central and peripheral adrenoceptors affect glucose, free fatty acids, and insulin in exercising rats

1988 ◽  
Vol 255 (4) ◽  
pp. R547-R556 ◽  
Author(s):  
A. J. Scheurink ◽  
A. B. Steffens ◽  
L. Benthem
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Blood Samples ◽  
Beta Adrenoceptor ◽  
Plasma Ffa ◽  
Glucose Plasma ◽  
Exercise Induced ◽  
Counter Current ◽  
Lateral Area

The effects of intravenously and intrahypothalamically administered alpha- and beta-adrenoceptor antagonists on exercise-induced alterations in blood glucose, plasma free fatty acids (FFA), and insulin were investigated in rats. Exercise consisted of strenuous swimming against a counter current for 15 min. Before, during, and after swimming, blood samples were withdrawn through a permanent heart catheter. Intravenous administration of the alpha-blocker phentolamine led to a reduction in glucose and a substantial increase in insulin levels. Infusion of phentolamine through permanent bilateral cannulas into either the ventromedial or lateral area of the hypothalamus (VMH and LHA, respectively) completely prevented the increase in glucose while the decline in insulin was unaffected. Infusion of phentolamine into the VMH caused much higher plasma FFA levels than in controls. The beta-blocker timolol given intravenously caused a delayed increase in glucose and prevented the increase in FFA. Infusion of timolol into either VMH or LHA caused a delay in the increase in both glucose and FFA. The results suggest that 1) both peripheral and hypothalamic adrenoceptors are involved in energy metabolism during exercise and 2) FFA, glucose, and insulin concentrations in blood are independently regulated by VMH and LHA.

scholarly journals Sympathoadrenal influence on glucose, FFA, and insulin levels in exercising rats

1989 ◽  
Vol 256 (1) ◽  
pp. R161-R168 ◽  
Author(s):  
A. J. Scheurink ◽  
A. B. Steffens ◽  
H. Bouritius ◽  
G. H. Dreteler ◽  
R. Bruntink ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Blood Glucose ◽  
Sympathetic Nerve ◽  
Intravenous Infusion ◽  
Blood Samples ◽  
Liver And Pancreas ◽  
Adrenoceptor Agonists ◽  
Glucose Plasma ◽  
Exercise Induced

The effects of sympathoadrenal manipulations on the exercise-induced alterations in blood glucose, plasma free fatty acids (FFA), and insulin were investigated in intact and adrenodemedullated rats. Exercise consisted of strenuous swimming against a countercurrent for 15 min. Before, during, and after swimming, blood samples were taken through a permanent heart catheter. Adrenodemedullation (Adm) markedly reduced the exercise-induced increase in both glucose and FFA. This effect was counteracted by intravenous infusion of epinephrine (E, 20 ng/min). Intravenous infusion of 50 ng E/min into Adm rats caused an exaggerated increase in glucose. In two additional experiments 1) specific adrenoceptor agonists and antagonists were administered to exercising intact and Adm rats, and 2) E or norepinephrine (NE; 20 ng/min) was infused into intact resting rats. The results suggest that E from the adrenal medulla directly affects glucose and insulin but not FFA concentrations in the blood. NE released from peripheral sympathetic nerve endings probably acts in two different ways: as neurotransmitter on liver and pancreas and as a hormone on adipose tissue.

Changes in blood glucose and plasma non-esterified fatty acids (NEFA) in relation to body condition scores in periparturient purebred Sahiwal cows

2018 ◽  
Author(s):  
V.N. Khune ◽  
Sharad Mishra ◽  
M.D. Bobade ◽  
V. Bhagat ◽  
Nishma Singh
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Body Condition ◽  
Transition Period ◽  
Post Partum ◽  
Nefa Concentration ◽  
Plasma Nefa ◽  
Esterified Fatty Acids ◽  
Sahiwal Cows ◽  
Body Condition Scores

The blood glucose and the plasma non-esterified fatty acids (NEFA) were estimated during extended transition period (56 days prepartum to 84 days postpartum) in relation to body condition scores in 26 purebred Sahiwal cows, 13 cows each from two farms i.e. the BMEF and CBF, Anjora, Durg, Chhattisgarh. BMEF herd concentrate was not fed to the animals during prepartum stage. In BMEF, the mean BCS at periodical intervals was significantly less than that of CBF herd throughout the transition period. The postpartum mean unit loss in BCS of the cows of BMEF herd (0.54±0.09) was significantly higher than that of CBF cows (0.52±0.09). The unit change in BCS was higher in magnitude till 42 days post partum in the cows of BMEF whereas it was lower in the cows of CBF. Non significantly higher mean blood glucose concentration was observed in the cows of BMEF (61.46±16 mg/dl) than the cows of CBF. The blood glucose level in both the herds was lower than as fore set range. The post partum mean NEFA concentration (0.138±0.015 mM/l) were significantly (P less than 0.01) higher than prepartum mean NEFA concentration (0.089±0.11mM/l) in BMEF cows however in CBF cows it remained same and differed non significantly. The overall mean plasma NEFA concentration in BMEF (0.116±0.010 mM/l) were significantly (P less than 0.01) higher than those of CBF (0.050±0.005 mM/l). In the cows of BMEF, NEFA value was higher than that of CBF and hence indicated a trend of reduction in BCS after calving. During prepartum period in BMEF and CBF cows, blodd glucose and plasma NEFA were negatively (with low “r”) correlated with BCS.

Sign in / Sign up

Export Citation Format

Share Document