Effects of growth hormone-releasing factors and cottonseed meal on hormones and metabolites in plasma from lambs fed lucerne chaff ad libitum

1994 ◽  
Vol 45 (6) ◽  
pp. 1125 ◽  
Author(s):  
RD Sainz ◽  
BJ Hosking ◽  
FJ Hart ◽  
GSG Spencer
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Growth Factor ◽  
Cottonseed Meal ◽  
Metabolic Effects ◽  
Insulin Like Growth Factor ◽  
Plasma Urea ◽  
Blood Samples ◽  
Esterified Fatty Acids ◽  
Ad Libitum

This study was part of an experiment on the effects of cottonseed meal (CSM) and growth hormone-releasing factor (GRF) on growth in lambs fed lucerne chaff. Forty-eight crossbred lambs were fed lucerne chaff ad libitum, alone or with a cottonseed meal supplement (CSM; 300 g/day). Eight lambs from each group were injected twice daily with recombinant or synthetic GRF (rGRF and sGRF respectively; 30 8g per kg body weight/day) or excipient only for 28 or 30 days. Jugular blood samples were obtained on days 0, 7, 14, 21 and 28. On day 29, blood samples were taken from selected lambs (n = 2/group) at 0, 20, 40, 60, 80, 100, 120, 160 and 240 min after injection. Supplementation of lucerne chaff with CSM generally increased glucose and urea concentrations in plasma, reflecting improved energy and protein status. However, concentrations of growth hormone, insulin-like growth factor-1 and insulin were unaffected by CSM, as were plasma proteins, triacylglycerols and non-esterified fatty acids. Injection of rGRF and sGRF stimulated secretion of growth hormone (GH), insulin-like growth factor-1 (IGF-1) and insulin. Peak GH concentrations (20 min) following injection of GRF appeared to be higher in lambs fed CSM than in those receiving lucerne chaff alone. In contrast, maximal concentrations of IGF-1 were seen after 14 days of treatment. These changes were accompanied by increased plasma glucose, with no changes in triacylglycerols, non-esterified fatty acids and protein. Plasma urea was reduced by GRF, indicating that amino acids were diverted away from catabolism towards protein synthesis. These two sources of GRF were very similar in their endocrine and metabolic effects. This confirms similar observations regarding their effects on growth performance and carcass composition.

scholarly journals Estradiol Effects on the Growth Hormone/Insulin-Like Growth Factor-1 Axis in Amenorrheic Athletes

2003 ◽  
Vol 28 (1) ◽  
pp. 64-78 ◽  
Author(s):  
Debra L. Waters ◽  
Richard I. Dorin ◽  
Clifford R. Qualls ◽  
Brent C. Ruby ◽  
Richard N. Baumgartner ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Growth Factor ◽  
Free Fatty Acids ◽  
Binding Protein ◽  
Nutritional Deficiencies ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Transdermal Estradiol ◽  
Igfbp 3

Disruption of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis has been reported and studied in menopause, hypothalamic amenorrhea, and anorexia nervosa, but not in weight-stable amenorrheic athletes. We investigated the effects of short-term transdermal estradiol on basal and exercise-stimulated serum GH, IGF-1, and associated binding proteins (IGFBP-1 and IGFBP-3) in seven weight-stable female amenorrheic athletes with percentage body fats greater that 12%. Each subject received a 72 h placebo patch followed by 144 h of transdermal estradiol. Serum samples for GH, IGF-1, IGFBP-1, and IGFBP-3 were obtained at baseline (t1), 72 hr (t2), 144 hr (t3), and during three 90-minute trials of aerobic exercise. Basal, and exercise GH, IGF-1, and IGFBP-1 were not different between trials. Baseline IGFBP-3 decreased from t1 to t2 (p = 0.04) and serum free fatty acids increased from t1 to t2, and t1 to t3 (p = 0.04, and 0.02 respectively). These findings differ from postmenopausal women, and women having weightloss-associated amenorrhea, suggesting that estrogen, exercise, and nutritional deficiencies may have independent effects on the GH/IGF-1 axis. Key words: transdermal estradiol, insulin-like growth factor binding protein-3, insulin-like growth factor binding protein-1, free fatty acids

Cardiac and metabolic effects of chronic growth hormone and insulin-like growth factor I excess in young adults with pituitary gigantism

Metabolism ◽  
2005 ◽  
Vol 54 (9) ◽  
pp. 1174-1180 ◽  
Author(s):  
Marta Bondanelli ◽  
Stefania Bonadonna ◽  
Maria Rosaria Ambrosio ◽  
Mauro Doga ◽  
Monica Gola ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Young Adults ◽  
Growth Factor ◽  
Metabolic Effects ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Specific depletion of body fat in parabiotic partners of tube-fed obese rats

1984 ◽  
Vol 247 (2) ◽  
pp. R380-R386 ◽  
Author(s):  
R. B. Harris ◽  
R. J. Martin
Keyword(s):  
Fatty Acids ◽  
Growth Hormone ◽  
Food Intake ◽  
Body Fat ◽  
Blood Samples ◽  
Reverse Triiodothyronine ◽  
Obese Rats ◽  
Ad Libitum ◽  
Beta Hydroxybutyrate ◽  
Normal Food

One member in each of 15 parabiosed pairs of rats was fed twice its normal food intake as four tube-fed meals per day. Seven other pairs ate ad libitum. Partners of overfed rats ate approximately 90% of the intake of individual members of ad libitum pairs. After 46 days of overfeeding, blood samples were taken and the rats were killed for carcass analysis. Tube-fed parabiotic rats had gained a considerable amount of fat and some protein. Their partners had a normal lean body mass but very little fat. Serum corticosterone, reverse triiodothyronine, free fatty acids, and beta-hydroxybutyrate were the same in all parabionts. Serum triiodothyronine and insulin were increased and growth hormone was decreased in obese rats. Serum thyroxine and triiodothyronine were increased and glucose was decreased in their parabiotic partners. The results are discussed as evidence for a humoral factor that crossed the parabiotic union and acted as a "lipid-depleting" agent in the partners of overfed rats.

scholarly journals Glucose related endocrine and metabolic responses following bolus intravenous hypertonic dextrose administration in Iranian fat-tailed ewes at different pre and post parturition periods

2020 ◽  
Vol 23 (1) ◽  
pp. 44-59
Author(s):  
A. Chalmeh ◽  
A. Mirzaei ◽  
M. Pourjafar ◽  
K. Badiei ◽  
M. Mazrouei Sebdani ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Growth Factor ◽  
Serum Levels ◽  
Metabolic Responses ◽  
Insulin Like Growth Factor ◽  
Hydroxybutyric Acid ◽  
Very Low Density Lipoproteins ◽  
Esterified Fatty Acids ◽  
Hypertonic Dextrose ◽  
Dextrose Infusion

Providing glucose as primary metabolic fuel for maintenance, foetal growth and milk production may be considered necessary for protection against negative energy balance and metabolic disorders. Five adult Ghezel ewes were selected 4 weeks before their parturition and followed at 2 weeks before, 2 and 4 weeks and 2, 3 and 4 months after parturition. Dextrose 50% was administered at 500 mg/kg, 10 mL/kg/hour, and blood samples were collected from all ewes prior to and 1, 2, 3 and 4 hours after 50% dextrose infusion. Serum levels of glucose, beta-hydroxybutyric acid, non-esterified fatty acids, cholesterol, triglyceride, high, low and very low density lipoproteins, insulin, triiodothyronine, thyroxine, prolactin, cortisol and insulin like growth factor-1 were evaluated. Glucose and insulin were increased significantly and immediately following intravenous dextrose administration at all studied periods. The levels of beta-hydroxybutyric acid and non-esterified fatty acids were significantly decreased following dextrose infusion at all periods. Triiodothyronine was decreased in pregnant ewes and increased in non-pregnant, lactating ones. The significant increasing cortisol patterns were detected at 2 and 4 weeks before and 2 and 4 weeks after parturition following dextrose administrations. The decreasing patterns of insulin like growth factor-1 were seen in all studied periods. Prolactin was significantly increased following dextrose administration at 4 and 2 weeks before and 2 weeks after parturition. Bolus intravenous hypertonic dextrose administration could induce the obvious endocrine and metabolic responses in Ghezel ewes via providing a source of energy and the glucose is an important direct controller of metabolic interactions in Ghezel ewes.

Serum IGF-1 and IGFBP-3 levels in subclinical hypothyroid women

Open Medicine ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. 158-162
Author(s):  
Huriye Balci ◽  
Tijen Erdem ◽  
Serdal Ugurlu ◽  
Demet Yetkin ◽  
I. Murat Bolayirli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Subclinical Hypothyroidism ◽  
Thyroid Peroxidase ◽  
Adult Women ◽  
Insulin Like Growth Factor ◽  
Thyroid Status ◽  
Blood Samples ◽  
The Relationship ◽  
Igfbp 3

AbstractThyroid status is known to influence growth in mammals. The aim of this study is to investigate the possible relationship between autoimmune subclinical hypothyroidism and growth hormone (GH), insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGFBP-3) levels. Thirty-five women with autoimmune subclinical hypothyroidism, 33 years of age, were used as controls and enrolled in the study. Free triiodothyronin (FT3), free thyroxin(FT4), thyrotropin(TSH), anti-thyroid peroxidase(Anti-TPO), anti-thyroglobuline(Anti-Tg), GH, IGF-1 and IGFBP-3 levels were measured in blood samples and correlations among these parameters were evaluated. We found no significant differences in GH, IGF-1 or IGFBP-3 between patients and controls. In patients and controls, there were no correlations among thyroid hormones and IGF-1 or IGFBP-3 levels, but GH levels were correlated with FT3, FT4 and TSH only in patients’ group. In controls, only IGF-1 and IGFBP-3 levels were correlated. The present study suggests that subclinical hypothyroidism with high TSH and antibody status does not affect IGF-1 and IGFBP-3 levels in adult women. To our knowledge, this is the first study concerning the relationship between autoimmune subclinical hypothyroidism and IGF-1 and IGFBP-3 levels.

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