The suppressive effect of tape-stripping treatment of guinea-pig skin on the induction of contact sensitivity by intradermal injection of haptenated epidermal cells

1985 ◽  
Vol 278 (2) ◽  
pp. 102-106 ◽  
Author(s):  
D. Oka ◽  
S. Nakagawa ◽  
H. Ueki
Keyword(s):  
Guinea Pig ◽  
Suppressive Effect ◽  
Intradermal Injection ◽  
Epidermal Cells ◽  
Tape Stripping ◽  
Contact Sensitivity ◽  
Pig Skin

scholarly journals Angioedema induced by a peptide derived from complement component C2.

1988 ◽  
Vol 168 (5) ◽  
pp. 1685-1698 ◽  
Author(s):  
C J Strang ◽  
S Cholin ◽  
J Spragg ◽  
A E Davis ◽  
E E Schneeberger ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Vascular Permeability ◽  
Synthetic Peptides ◽  
Intradermal Injection ◽  
Amino Acid Residues ◽  
Terminal Sequence ◽  
Small Peptides ◽  
Rat Uterus ◽  
Pig Skin ◽  
Antihistaminic Drugs

Synthetic peptides that correspond to the COOH-terminal portion of C2b enhance vascular permeability in human and guinea pig skin. In human studies, 1 nmol of the most active peptide of 25-amino acid residues produced substantial local edema. A pentapeptide and a heptapeptide corresponding to the COOH-terminal sequence of C2b each induced contraction of estrous rat uterus in the micromole range; a peptide of 25 amino acids from this region induced a like contraction of rat uterus at a concentration 20-fold lower than the smaller peptides. The vascular permeability of guinea pig skin was enhanced by doses of these synthetic peptides in a similar fashion as that observed for the concentration of rat uterus. The induction of localized edema by intradermal injection in both the guinea pig and the human proceeds in the presence of antihistaminic drugs, suggesting that there is a histamine-independent component to the observed increase in vascular permeability. Cleavage of C2 with the enzymic subcomponent of C1, C1s, yields only C2a and C2b, and no small peptides, whereas cleavage of C2 with C1s and plasmin yields a set of small peptides. These plasmin-cleaved peptides are derived from the COOH terminus of C2b, and they induce the contraction of estrous rat uterus.

Suppressive Effect of Ultraviolet-B-Irradiation of Epidermal Cells on the Induction of Contact Sensitivity

1986 ◽  
Vol 30 (1) ◽  
pp. 65-74
Author(s):  
Tetsuo Tsuchida ◽  
Masahiko Takemura ◽  
Ja-Hua Qian ◽  
Yutaka Izumi ◽  
Toshiaki Mizuochi ◽  
...  
Keyword(s):  
Suppressive Effect ◽  
Epidermal Cells ◽  
Ultraviolet B ◽  
Contact Sensitivity ◽  
Ultraviolet B Irradiation

scholarly journals Epidermal cells adhere preferentially to type IV (basement membrane) collagen.

1979 ◽  
Vol 80 (1) ◽  
pp. 197-202 ◽  
Author(s):  
J C Murray ◽  
G Stingl ◽  
H K Kleinman ◽  
G R Martin ◽  
S I Katz
Keyword(s):  
Basement Membrane ◽  
Guinea Pig ◽  
Dermal Fibroblasts ◽  
Epidermal Cells ◽  
Pig Skin ◽  
Type Iv ◽  
Basement Membrane Collagen ◽  
Membrane Collagen

Epidermal cells from adult guinea pig skin attach and differentiate preferentially on substrates of type IV (basement membrane) collagen, compared to those of types I--III collagen. In contrast, guinea pig dermal fibroblasts attach equally well to all four collagen substrates. Fibronectin mediates the attachment of fibroblasts but not of epidermal cells to collagen.

scholarly journals THE SPECIFICITY OF ALLERGIC REACTIONS

1961 ◽  
Vol 114 (2) ◽  
pp. 185-194 ◽  
Author(s):  
S. B. Salvin ◽  
R. F. Smith
Keyword(s):  
Guinea Pig ◽  
Intradermal Injection ◽  
Contact Hypersensitivity ◽  
Allergic Reactions ◽  
Oil Emulsion ◽  
Pig Skin ◽  
Intradermal Administration ◽  
Water In Oil Emulsion ◽  
Circulating Antibody ◽  
Pig Serum

Intradermal injection of a simple hapten (e.g., 1-fluoro-2,4-dinitrobenzene) in water-in-oil emulsion results in contact hypersensitivity to surface application of the homologous hapten and, after appearance of circulating antibody, in Arthus type hypersensitivity to a conjugate of homologous hapten with guinea pig serum. Intradermal administration of this conjugate induces delayed and subsequently Arthus hypersensitivity to the conjugate, but no evidence of a contact reaction to the hapten alone. When a conjugate of hapten plus solubilized guinea pig skin is used as the sensitizing antigen, both contact hypersensitivity to the hapten and delayed and/or Arthus reactions to the conjugate develop. These observations are consistent with the hypothesis that the specificity of contact sensitivity is directed toward some particular protein of the skin which has been modified by combination with hapten.

scholarly journals Cutaneous lipogenesis: precursors utilized by guinea pig skin for lipid synthesis

1971 ◽  
Vol 12 (3) ◽  
pp. 347-360
Author(s):  
VICTOR R. WHEATLEY ◽  
LEONARD T. HODGINS ◽  
WILLIAM M. COON ◽  
MUTUKUMARA KUMARASIRI ◽  
HAROLD BERENZWEIG ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Lipid Synthesis ◽  
Pig Skin

Cyclic AMP-Elevating Agents Inhibit Proliferation of Keratinizing Guinea Pig Epidermal Cells

1974 ◽  
Vol 2 (6) ◽  
pp. 343-350 ◽  
Author(s):  
C. Delescluse ◽  
N.H. Colburn ◽  
E.A. Duell ◽  
J.J. Voorhees
Keyword(s):  
Cyclic Amp ◽  
Guinea Pig ◽  
Epidermal Cells
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