The use of the urinary excretion of delta-aminolevulinic acid as a criterion for lead absorption in industrial medicine and insurance medicine

1977 ◽  
Vol 39 (3) ◽  
pp. 191-198 ◽  
Author(s):  
D. Lahaye ◽  
D. Roosels ◽  
J. -M. Bossiroy ◽  
F. van Assche
Keyword(s):  
Urinary Excretion ◽  
Aminolevulinic Acid ◽  
Insurance Medicine ◽  
Lead Absorption ◽  
Industrial Medicine

Thiamine and Zinc in Prevention or Therapy of Lead Intoxication

1989 ◽  
Vol 17 (1) ◽  
pp. 68-75 ◽  
Author(s):  
S. J. S. Flora ◽  
S. Singh ◽  
S. K. Tandon
Keyword(s):  
Urinary Excretion ◽  
Lead Exposure ◽  
Intestinal Tract ◽  
Aminolevulinic Acid ◽  
Lead Toxicity ◽  
Dietary Supplementation ◽  
Lead In Blood ◽  
Liver And Kidney ◽  
Gastro Intestinal Tract ◽  
Dehydratase Activity

Thiamine, zinc or their combination given through gastric gavage were investigated for their ability to prevent or treat experimental lead toxicity in rats. Simultaneous dietary supplementation with thiamine plus zinc was found to be the most effective way of reducing the lead-induced inhibition of δ-aminolevulinic acid dehydratase activity in blood, urinary excretion of δ-aminolevulinic acid and accumulation of lead in blood, liver and kidney. Prevention was more effective than post-lead exposure treatment which may be due mainly to the decrease in the absorption of lead in the gastro-intestinal tract in the presence of thiamine and/or zinc.

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