scholarly journals Characterization of the insulin-antagonistic effect of growth hormone in man

Diabetologia ◽  
1991 ◽  
Vol 34 (7) ◽  
pp. 500-506 ◽  
Author(s):  
J. Fowelin ◽  
S. Attvall ◽  
H. von Schenck ◽  
U. Smith ◽  
I. Lager
Keyword(s):  
Growth Hormone ◽  
Antagonistic Effect

scholarly journals Characterization of Direct Perturbations on Voltage-Gated Sodium Current by Esaxerenone, a Nonsteroidal Mineralocorticoid Receptor Blocker

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 549
Author(s):  
Wei-Ting Chang ◽  
Sheng-Nan Wu
Keyword(s):  
Mineralocorticoid Receptor ◽  
Sodium Current ◽  
Ionic Currents ◽  
Antagonistic Effect ◽  
Gh3 Cells ◽  
Excitable Cells ◽  
Voltage Gated ◽  
Ic50 Value ◽  
Low Threshold

Esaxerenone (ESAX; CS-3150, Minnebro®) is known to be a newly non-steroidal mineralocorticoid receptor (MR) antagonist. However, its modulatory actions on different types of ionic currents in electrically excitable cells remain largely unanswered. The present investigations were undertaken to explore the possible perturbations of ESAX on the transient, late and persistent components of voltage-gated Na+ current (INa) identified from pituitary GH3 or MMQ cells. GH3-cell exposure to ESAX depressed the transient and late components of INa with varying potencies. The IC50 value of ESAX required for its differential reduction in peak or late INa in GH3 cells was estimated to be 13.2 or 3.2 μM, respectively. The steady-state activation curve of peak INa remained unchanged during exposure to ESAX; however, recovery of peak INa block was prolonged in the presence 3 μM ESAX. In continued presence of aldosterone (10 μM), further addition of 3 μM ESAX remained effective at inhibiting INa. ESAX (3 μM) potently reversed Tef-induced augmentation of INa. By using isosceles-triangular ramp pulse with varying durations, the amplitude of persistent INa measured at high or low threshold was enhanced by the presence of tefluthrin (Tef), in combination with the appearance of the figure-of-eight hysteretic loop; moreover, hysteretic strength of the current was attenuated by subsequent addition of ESAX. Likewise, in MMQ lactotrophs, the addition of ESAX also effectively decreased the peak amplitude of INa along with the increased current inactivation rate. Taken together, the present results provide a noticeable yet unidentified finding disclosing that, apart from its antagonistic effect on MR receptor, ESAX may directly and concertedly modify the amplitude, gating properties and hysteresis of INa in electrically excitable cells.

Characterization of reactive blue 2 antagonistic effect on vascular ATP receptors

1992 ◽  
Vol 25 ◽  
pp. 164-165
Author(s):  
E. Ragazzi ◽  
A. Chinellato ◽  
L. Pandolfo ◽  
G. Froldi ◽  
L. Caparrotta ◽  
...  
Keyword(s):  
Antagonistic Effect ◽  
Reactive Blue 2 ◽  
Atp Receptors

Design and characterization of a fluorescent ghrelin analog for imaging the growth hormone secretagogue receptor 1a

2011 ◽  
Vol 172 (1-3) ◽  
pp. 69-76 ◽  
Author(s):  
Rebecca McGirr ◽  
Mark S. McFarland ◽  
Jillian McTavish ◽  
Leonard G. Luyt ◽  
Savita Dhanvantari
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue

Identification and Immunochemical Characterization of a Major Placental Secretory Protein Related to the Prolactin-Growth Hormone Family, Prolactin-Like Protein-C*

Endocrinology ◽  
1991 ◽  
Vol 128 (6) ◽  
pp. 3066-3072 ◽  
Author(s):  
SANTANU DEB ◽  
KATHERINE F. ROBY ◽  
TERESA N. FARIA ◽  
DOUGLAS LARSEN ◽  
MICHAEL J. SOARES
Keyword(s):  
Growth Hormone ◽  
Protein C ◽  
Secretory Protein ◽  
Immunochemical Characterization

scholarly journals Characterization of actinobacteria from the semiarid region, and their antagonistic effect on strains of rhizobia

2017 ◽  
Vol 16 (11) ◽  
pp. 499-507 ◽  
Author(s):  
Vinicius Leite Lima Jose ◽  
Claudia Silveira Martins Suzana ◽  
Aparecida de Siqueira Katia ◽  
Antonio Soares Marcos ◽  
Miranda Martins Claudia
Keyword(s):  
Antagonistic Effect ◽  
Semiarid Region
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