scholarly journals Role of infiltrating T cells for impaired glucose metabolism in pancreatic islets isolated from non-obese diabetic mice

Diabetologia ◽  
1992 ◽  
Vol 35 (10) ◽  
pp. 924-931 ◽  
Author(s):  
E. Strandell ◽  
S. Sandler ◽  
C. Boitard ◽  
D. L. Eizirik
Keyword(s):  
T Cells ◽  
Glucose Metabolism ◽  
Pancreatic Islets ◽  
Diabetic Mice ◽  
Impaired Glucose Metabolism

scholarly journals Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 554
Author(s):  
Stefania Croce ◽  
Maria Antonietta Avanzini ◽  
Corrado Regalbuto ◽  
Erika Cordaro ◽  
Federica Vinci ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Th17 Cells ◽  
Metabolic Disorders ◽  
Potential Role ◽  
Immune Monitoring ◽  
Metabolic Dysfunction ◽  
Impaired Glucose Metabolism ◽  
T Cell Infiltration

In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a chronic disease correlated with systemic inflammation, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity related diseases and metabolic disorders, including impaired glucose metabolism. In particular, Treg and Th17 cells are dynamically balanced under healthy conditions, but imbalance occurs in inflammatory and pathological states, such as obesity. Some studies demonstrated that peripheral Treg and Th17 cells exhibit increased imbalance with worsening of glucose metabolic dysfunction, already in children with obesity. In this review, we considered the role of adipose tissue immunomodulation and the potential role played by Treg/T17 imbalance on the impaired glucose metabolism in pediatric obesity. In the patient care, immune monitoring could play an important role to define preventive strategies of pediatric metabolic disease treatments.

Role of high-risk variants in the development of impaired glucose metabolism was modified by birth weight in Han Chinese

2015 ◽  
Vol 31 (8) ◽  
pp. 790-795 ◽  
Author(s):  
Yun Zhang ◽  
Xinhua Xiao ◽  
Zhenxin Zhang ◽  
Xuejun Ma ◽  
Tao Xu ◽  
...  
Keyword(s):  
Birth Weight ◽  
High Risk ◽  
Glucose Metabolism ◽  
Han Chinese ◽  
Impaired Glucose Metabolism ◽  
Risk Variants

scholarly journals Role of Chemokine Receptor CCR4 and Regulatory T Cells in Wound Healing of Diabetic Mice

2019 ◽  
Vol 139 (5) ◽  
pp. 1161-1170 ◽  
Author(s):  
Janaína F. Barros ◽  
Ingrid Waclawiak ◽  
Cyntia Pecli ◽  
Paula A. Borges ◽  
Janaína L. Georgii ◽  
...  
Keyword(s):  
Wound Healing ◽  
T Cells ◽  
Regulatory T Cells ◽  
Chemokine Receptor ◽  
Diabetic Mice ◽  
Chemokine Receptor Ccr4

Role of Impaired Glucose Metabolism in the Postherpetic Neuralgia

2013 ◽  
Vol 29 (8) ◽  
pp. 733-736 ◽  
Author(s):  
Domenico Bosco ◽  
Massimiliano Plastino ◽  
Matteo De Bartolo ◽  
Dario Cristiano ◽  
Maria Ettore ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Postherpetic Neuralgia ◽  
Impaired Glucose Metabolism

Phosphate flush and glucose metabolism in pancreatic islets of young and old diabetic mice (C57BL/KsJ-db/db)

1984 ◽  
Vol 105 (4) ◽  
pp. 539-544 ◽  
Author(s):  
Ove Berglund ◽  
Janove Sehlin ◽  
Inge-Bert Täljedal
Keyword(s):  
Glucose Metabolism ◽  
Pancreatic Islets ◽  
Glucose Concentration ◽  
Diabetic Mouse ◽  
Percentage Increase ◽  
Diabetic Mice ◽  
Ionic Fluxes ◽  
Cell Plasma ◽  
Significant Difference ◽  
Mouse Islets

Abstract. Pancreatic islets from normal C57BL/KsJ–+/+–mice and diabetic C57BL/KsJ-db/db-mice were collagenase-isolated and incubated with 33P-labelled inorganic phosphate. No significant difference was observed in phosphate uptake between normal and diabetic mouse islets whether the animals were young (6–8 weeks) or old (27 ± 9 weeks). When 33P-labelled islets were perifused with non-radioactive medium, all types of islets exhibited a brisk and transient peak of phosphate release in response to a change of glucose concentration from 2.8 to 16.7 mmol/l. Expressed in absolute terms, both the basal and peak efflux of phosphate appeared to be diminished in the diabetic mice. In relative terms (peak over basal), the glucose-stimulated phosphate efflux was not lower in diabetic than in normal mice. At both a low (3 mmol/l) and a high (20 mmol/l) glucose concentration, the production of 3H2O from d-[5-3H]glucose was reduced in old but not in young diabetic mouse islets. The percentage increase in glucose metabolism in response to a rise in glucose concentration from 3 to 20 mmol/l was about the same in all types of islets. The results add to previous observations of disturbed ionic fluxes in the pancreatic islets of diabetic KsJ-db/db-mice. These effects are probably not due to gross alterations in glycolytic metabolism but more probably reflect alterations in the function of the β-cell plasma membrane.

scholarly journals Impaired glucose metabolism and type 2 diabetes are associated with hypercoagulability: potential role of central adiposity and low-grade inflammation – The Hoorn Study

2012 ◽  
Vol 129 (5) ◽  
pp. 557-562 ◽  
Author(s):  
Hanneke J.B.H. Beijers ◽  
Isabel Ferreira ◽  
Henri M.H. Spronk ◽  
Bert Bravenboer ◽  
Jacqueline M. Dekker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Metabolism ◽  
Potential Role ◽  
Low Grade ◽  
Central Adiposity ◽  
Impaired Glucose Metabolism ◽  
Low Grade Inflammation
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