Role of high-risk variants in the development of impaired glucose metabolism was modified by birth weight in Han Chinese

2015 ◽  
Vol 31 (8) ◽  
pp. 790-795 ◽  
Author(s):  
Yun Zhang ◽  
Xinhua Xiao ◽  
Zhenxin Zhang ◽  
Xuejun Ma ◽  
Tao Xu ◽  
...  
Keyword(s):  
Birth Weight ◽  
High Risk ◽  
Glucose Metabolism ◽  
Han Chinese ◽  
Impaired Glucose Metabolism ◽  
Risk Variants

scholarly journals Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 554
Author(s):  
Stefania Croce ◽  
Maria Antonietta Avanzini ◽  
Corrado Regalbuto ◽  
Erika Cordaro ◽  
Federica Vinci ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Th17 Cells ◽  
Metabolic Disorders ◽  
Potential Role ◽  
Immune Monitoring ◽  
Metabolic Dysfunction ◽  
Impaired Glucose Metabolism ◽  
T Cell Infiltration

In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a chronic disease correlated with systemic inflammation, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity related diseases and metabolic disorders, including impaired glucose metabolism. In particular, Treg and Th17 cells are dynamically balanced under healthy conditions, but imbalance occurs in inflammatory and pathological states, such as obesity. Some studies demonstrated that peripheral Treg and Th17 cells exhibit increased imbalance with worsening of glucose metabolic dysfunction, already in children with obesity. In this review, we considered the role of adipose tissue immunomodulation and the potential role played by Treg/T17 imbalance on the impaired glucose metabolism in pediatric obesity. In the patient care, immune monitoring could play an important role to define preventive strategies of pediatric metabolic disease treatments.

scholarly journals Role of infiltrating T cells for impaired glucose metabolism in pancreatic islets isolated from non-obese diabetic mice

Diabetologia ◽  
1992 ◽  
Vol 35 (10) ◽  
pp. 924-931 ◽  
Author(s):  
E. Strandell ◽  
S. Sandler ◽  
C. Boitard ◽  
D. L. Eizirik
Keyword(s):  
T Cells ◽  
Glucose Metabolism ◽  
Pancreatic Islets ◽  
Diabetic Mice ◽  
Impaired Glucose Metabolism

Role of Impaired Glucose Metabolism in the Postherpetic Neuralgia

2013 ◽  
Vol 29 (8) ◽  
pp. 733-736 ◽  
Author(s):  
Domenico Bosco ◽  
Massimiliano Plastino ◽  
Matteo De Bartolo ◽  
Dario Cristiano ◽  
Maria Ettore ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Postherpetic Neuralgia ◽  
Impaired Glucose Metabolism

scholarly journals Impaired glucose metabolism and type 2 diabetes are associated with hypercoagulability: potential role of central adiposity and low-grade inflammation – The Hoorn Study

2012 ◽  
Vol 129 (5) ◽  
pp. 557-562 ◽  
Author(s):  
Hanneke J.B.H. Beijers ◽  
Isabel Ferreira ◽  
Henri M.H. Spronk ◽  
Bert Bravenboer ◽  
Jacqueline M. Dekker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Metabolism ◽  
Potential Role ◽  
Low Grade ◽  
Central Adiposity ◽  
Impaired Glucose Metabolism ◽  
Low Grade Inflammation

Abstract 91: Sex and Race Differences in Diabetes and Risk of Ischemic Stroke: Role of Fasting Blood Glucose

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Tracy E Madsen ◽  
D. Leann Long ◽  
April P Carson ◽  
George Howard ◽  
Dawn O Kleindorfer ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Blood Glucose ◽  
Glucose Metabolism ◽  
Racial Differences ◽  
White Women ◽  
Fasting Blood Glucose ◽  
Medication Use ◽  
Race Differences ◽  
Impaired Glucose Metabolism

Introduction: There are known sex and race differences in the risk of incident ischemic stroke (IS) associated with diabetes mellitus (DM), but the mechanism is unclear. To explore the role of impaired glucose metabolism in such differences, we aimed to determine if there are differences in the risk of IS across increasing fasting blood glucose (FBG) by race/sex subgroups. Methods: We analyzed data from black and white adults age ≥45 years at baseline (2003-2007) without a history of stroke from the Reasons for Geographic And Racial Differences in Stroke Study, a national longitudinal cohort. Data on age, race, sex, FBG, and DM medications was collected at baseline, and IS events were ascertained by phone every 6 months with physician adjudication of suspected events through September 2018. Cox proportional hazards regression was used to assess the association between FBG (<100 (ref), 100-125, 126-150, >150 mg/dL) and IS in sex/race groups (white women (WW), black women (BW), white men (WM), black men (BM)), stratified by DM medication use (DM medication use vs. no DM medication use) after adjustment for demographics, comorbidities, education, and income . Results: Of the 20,338 participants, mean age was 64.5(SD 9.3) years, 38.7% were black, 55.4% were women and 16.2% were using DM medications. There were 954 events. Of those on DM medication, the association between FBG and IS varied by race/sex (adjusted hazard ratios for FBG > 150 compared to FBG <100: WW 3.30 (95% CI 1.20, 9.10), BW 2.02 (95%CI 1.06, 3.87), BM 1.24 (95%CI 0.63, 2.46), WM 1.08 (95%CI 0.53, 2.17), p=0.08). Among those not on diabetes medications, IS risk across FBG did not vary by race/sex (p=0.36) (Table). Conclusions: Among those using diabetes medications, the magnitude of the association of increasing FBG with incident IS is highest among white women compared with other race/sex subgroups, suggesting possible race and sex differences in the role of impaired glucose metabolism in stroke risk.

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