scholarly journals Relationship between haemoglobin A1c in early type 1 (insulin-dependent) diabetic pregnancy and the occurrence of spontaneous abortion and fetal malformation in Sweden

Diabetologia ◽  
1990 ◽  
Vol 33 (2) ◽  
pp. 100-104 ◽  
Author(s):  
U. Hanson ◽  
B. Persson ◽  
S. Thunell
Diabetologia ◽  
1990 ◽  
Vol 33 (6) ◽  
pp. 378-383 ◽  
Author(s):  
J. A. Widness ◽  
K. A. Teramo ◽  
G. K. Clemons ◽  
P. Voutilainen ◽  
U. -H. Stenman ◽  
...  

1986 ◽  
Vol 70 (2) ◽  
pp. 127-129 ◽  
Author(s):  
C. J. Story ◽  
A. P. Roberts ◽  
R. G. Ryall

1. Erythrocyte 2,3-diphosphoglycerate and haemoglobin A1C concentrations were measured in 26 clinically normoxic patients with type 1 (insulin dependent) diabetes mellitus. The concentration of 2,3-diphosphoglycerate theoretically required to maintain normal erythrocyte oxygen delivery function in each subject was calculated and compared with the measured concentrations. 2. In the majority of diabetic patients 2,3-diphosphoglycerate concentrations were sufficient to keep the erythrocyte oxygen dissociation curve within the normal range under otherwise normal blood conditions. There was, however, a minority of patients in which this was not true. 3. It is concluded that the increased erythrocyte 2,3-diphosphoglycerate concentrations in clinically normoxic diabetic subjects are generally less than compensatory for the effect of haemoglobin A1C formation on the haemoglobin-oxygen dissociation curve.


Diabetologia ◽  
1984 ◽  
Vol 26 (4) ◽  
Author(s):  
D.R. Hadden ◽  
E. Byrne ◽  
I. Trotter ◽  
J.M.G. Harley ◽  
G. McClure ◽  
...  

Diabetologia ◽  
1986 ◽  
Vol 29 (6) ◽  
pp. 358-361 ◽  
Author(s):  
K. Hermansen ◽  
O. Rasmussen ◽  
J. Arnfred ◽  
E. Winther ◽  
O. Schmitz

1987 ◽  
Vol 72 (1) ◽  
pp. 123-130 ◽  
Author(s):  
J. Kastrup ◽  
T. Nørgaard ◽  
H.-H. Parving ◽  
N. A. Lassen

1. The distensibility of the resistance vessels of the skin at the dorsum of the foot was determined in 11 long-term type 1 (insulin-dependent) diabetic patients with nephropathy and retinopathy, nine short-term type 1 diabetic patients without clinical microangiopathy and in nine healthy non-diabetic subjects. 2. Blood flow was measured by the local 133Xexenon washout technique in a vascular bed locally paralysed by the injection of histamine. Blood flow was measured before, during and after a 40 mmHg increase of the vascular transmural pressure, induced by head-up tilt. 3. The mean increase in blood flow during headup tilt was only 24% in diabetic subjects with and 48% in diabetic patients without clinical microangiopathy, compared with 79% in normal non-diabetic subjects (P < 0.0005 and P < 0.05, respectively). 4. An inverse correlation between microvascular distensibility and degree of hyalinosis of the terminal arterioles in biopsies from the skin was demonstrated (r = − 0.57, P < 0.001). 5. Our results suggest that terminal arteriolar hyalinosis reduces the microvascular distensibility and probably increases the minimal vascular resistance, thereby impeding hyperaemic responses.


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