Balanced and unbalanced pericentric inversion of a chromosome 14

1978 ◽  
Vol 43 (1) ◽  
pp. 103-106 ◽  
Author(s):  
R. A. Pfeiffer ◽  
E. Kessel
Keyword(s):  
Pericentric Inversion ◽  
Chromosome 14

A novel pericentric inversion of chromosome 14 involving the rRNA gene cluster

2005 ◽  
Vol 25 (7) ◽  
pp. 620-621 ◽  
Author(s):  
Natalia T Leach ◽  
Suzanne M Cole ◽  
Deborah J Sandstrom ◽  
Stanislawa Weremowicz
Keyword(s):  
Gene Cluster ◽  
Pericentric Inversion ◽  
Rrna Gene ◽  
Chromosome 14

Recombinant chromosome 14 due to maternal pericentric inversion

2008 ◽  
Vol 49 (2) ◽  
pp. 205-207 ◽  
Author(s):  
Vytautas Šliužas ◽  
Algirdas Utkus ◽  
Vaidutis Kučinskas
Keyword(s):  
Pericentric Inversion ◽  
Chromosome 14 ◽  
Recombinant Chromosome

Chromosome 14 Contains Determinants That Regulate Susceptibility to Theiler's Virus–Induced Demyelination in the Mouse

Genetics ◽  
1998 ◽  
Vol 148 (4) ◽  
pp. 1941-1949
Author(s):  
J-F Bureau ◽  
K M Drescher ◽  
L R Pease ◽  
T Vikoren ◽  
M Delcroix ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Major Histocompatibility Complex ◽  
Linkage Analysis ◽  
Demyelinating Disease ◽  
Theiler's Virus ◽  
Chromosome 14 ◽  
Virus Persistence ◽  
Histocompatibility Complex ◽  
Encephalomyelitis Virus ◽  
Two Peaks

Abstract Theiler's murine encephalomyelitis virus causes a chronic demyelinating disease in susceptible strains of mice that is similar to human multiple sclerosis. Several nonmajor histocompatibility complex–linked genes have been implicated as determinants of susceptibility or resistance to either demyelination or virus persistence. In this study, we used linkage analysis of major histocompatibility complex identical H-2d (DBA/2J × B10.D2) F2 intercross mice to identify loci associated with susceptibility to virus-induced demyelinating disease. In a 20-cM region on chromosome 14, we identified four markers, D14Mit54, D14Mit60, D14Mit61, and D14Mit90 that are significantly associated with demyelination. Because two peaks were identified, one near D14Mit54 and one near D14Mit90, it is possible that two loci in this region are involved in controlling demyelination.

scholarly journals Molecular and Functional Mapping of the Piebald Deletion Complex on Mouse Chromosome 14

Genetics ◽  
2001 ◽  
Vol 157 (2) ◽  
pp. 803-815
Author(s):  
Jeffrey J Roix ◽  
Aaron Hagge-Greenberg ◽  
Dennis M Bissonnette ◽  
Sandra Rodick ◽  
Liane B Russell ◽  
...  
Keyword(s):  
Mouse Chromosome ◽  
System Development ◽  
Genomic Region ◽  
Nervous System Development ◽  
Chromosome 14 ◽  
Developmental Defects ◽  
Oak Ridge ◽  
Recessive Mutations ◽  
Large Deletions ◽  
Critical Regions

Abstract The piebald deletion complex is a set of overlapping chromosomal deficiencies surrounding the endothelin receptor B locus collected during the Oak Ridge specific-locus-test mutagenesis screen. These chromosomal deletions represent an important resource for genetic studies to dissect the functional content of a genomic region, and several developmental defects have been associated with mice homozygous for distinct piebald deletion alleles. We have used molecular markers to order the breakpoints for 20 deletion alleles that span a 15.7–18-cM region of distal mouse chromosome 14. Large deletions covering as much as 11 cM have been identified that will be useful for regionally directed mutagenesis screens to reveal recessive mutations that disrupt development. Deletions identified as having breakpoints positioned within previously described critical regions have been used in complementation studies to further define the functional intervals associated with the developmental defects. This has focused our efforts to isolate genes required for newborn respiration and survival, skeletal patterning and morphogenesis, and central nervous system development.

scholarly journals Fertility problems in males carrying an inversion of chromosome 10

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 316-321
Author(s):  
Xinyue Zhang ◽  
Qingyang Shi ◽  
Yanhong Liu ◽  
Yuting Jiang ◽  
Xiao Yang ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Pericentric Inversion ◽  
Paracentric Inversion ◽  
Chromosome 10 ◽  
Partial Duplication ◽  
Recurrent Miscarriages ◽  
First Case ◽  
Fertility Problems ◽  
Male Carriers ◽  
Male Carrier

Abstract Chromosomal inversion is closely related to male infertility. Inversion carriers may produce abnormal gametes, which may lead to partial duplication/deletion of the embryonic chromosome and result in spontaneous abortion, a fetus with multiple anomalies, or birth of a malformed child. Genetic counselling remains challenging for these carriers in clinical practice. We report two male carriers with inversion of chromosome 10 and review 26 reported cases. In the first case, 46,XX,inv(10)(p13q22) of the fetal chromosome was found in prenatal diagnosis; this was inherited from the paternal side with 46XY,inv(10)(p13q22). Another case was a male carrier with inv(10)(q21.2q22.1). There have been 25 (89.3%) cases of pericentric inversion and three (10.7%) cases of paracentric inversion involving chromosome 10. Of 28 cases, nine were associated with pregestational infertility of the couples, while the other 19 cases were associated with gestational infertility of the couples or normozoospermia. The breakpoints at 10p15, 10p11, 10q11, and 10q21 were associated with pregestational infertility of the couples. The breakpoints at 10p15, 10p14, 10p13, 10p12, 10p11, 10q11, 10q21, 10q22, 10q23, 10q24, 10q25, and 10q26 were related to gestational infertility of the couples or normozoospermia. Although there is a high risk of infertility or recurrent miscarriages, carriers with inversion of chromosome 10 might produce healthy offspring. Natural pregnancy can be used as a choice for inversion carriers with recurrent spontaneous abortion.

Prenatal Diagnosis in Pericentric Inversion 6

2010 ◽  
Vol 10 (1-3) ◽  
pp. 175-178 ◽  
Author(s):  
J. Gazala ◽  
I. V. Amithkumar ◽  
J. Sabina ◽  
K.K. Praveena ◽  
J. Sujatha
Keyword(s):  
Prenatal Diagnosis ◽  
Pericentric Inversion

Mouse Chromosome 14

1999 ◽  
Vol 10 (10) ◽  
pp. 955-955
Author(s):  
Rosemary W. Elliott
Keyword(s):  
Mouse Chromosome ◽  
Chromosome 14
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