Spontaneous chromosome aberrations in human somatic cells

1972 ◽  
Vol 16 (1-2) ◽  
pp. 159-164 ◽  
Author(s):  
N. P. Bochkov
Keyword(s):  
Chromosome Aberrations ◽  
Somatic Cells ◽  
Spontaneous Chromosome

scholarly journals HIGH RATES OF OCCURRENCE OF SPONTANEOUS CHROMOSOME ABERRATIONS IN DROSOPHILA MELANOGASTER

Genetics ◽  
1976 ◽  
Vol 83 (2) ◽  
pp. 409-422
Author(s):  
Osamu Yamaguchi ◽  
Ricardo A Cardellino ◽  
Terumi Mukai
Keyword(s):  
Chromosome Aberrations ◽  
Gene Arrangement ◽  
Reciprocal Translocations ◽  
Lethal Effects ◽  
Recessive Lethal ◽  
The Third ◽  
Lethal Mutations ◽  
Pericentric Inversions ◽  
Break Points ◽  
Spontaneous Chromosome

ABSTRACT Spontaneous mutations were accumulated for 40 generations in 140 unrelated second chromosomes with the standard gene arrangement. These were extracted from the same population by using the marked inversion technique, and the following findings were obtained: (1) In 42 out of the 140 chromosome lines, chromosome aberrations were detected by examining the salivary gland chromosomes: 40 paracentric and 15 pericentric inversions, 2 reciprocal translocations between the second and the third chromosomes, and 6 transpositions. (2) In 63 out of the 90 originally lethal-free lines, recessive lethal mutations occurred. (3) There were only 3 lines that acquired chromosome aberrations (inversions) with no lethal effects in the homozygous condition. (4) In a comparison of these results with those of the (CH), (PQ), and (RT) chromosomes in which no chromosome aberrations occurred after accumulating mutations for 22058 chromosome·generations (Yamaguchi and Mukai 1974), it was concluded that some of these 140 chromosomes carried a kind of mutator. (5) The frequency of mutator-carrying chromosome lines was estimated to be 0.66 on the basis of the distribution of the break-points on the chromosome lines and the frequency of lines that acquired neither recessive lethal mutations nor chromosome aberrations. Thus, the average number of breaks per mutator-carrying chromosome was estimated to be about 0.19/generation. On the basis of these estimates, the nature of the mutator factor was discussed.

SPONTANEOUS CHROMOSOME ABERRATIONS IN ALLIUM

Genetics ◽  
1941 ◽  
Vol 26 (1) ◽  
pp. 89-100 ◽  
Author(s):  
Charles Nichols
Keyword(s):  
Chromosome Aberrations ◽  
Spontaneous Chromosome

BIOLOGICAL EFFECTS OBSERVED IN MAMMALS MAINTAINED IN AN AREA OF VERY HIGH NATURAL RADIOACTIVITY

1981 ◽  
Vol 23 (2) ◽  
pp. 321-326 ◽  
Author(s):  
A. Léonard ◽  
M. Delpoux ◽  
J. Chameaud ◽  
G. Decat ◽  
E. D. Léonard
Keyword(s):  
Natural Radioactivity ◽  
Chromosome Aberrations ◽  
Biological Effects ◽  
Somatic Cells ◽  
Summer Period ◽  
Natural Radiation ◽  
Radon Exposure ◽  
Males And Females ◽  
A Site ◽  
Very High

Male rabbits (Oryctolagus cuniculus) were maintained for a 28-month period on the floor of a hut built at a site in southwestern France where the dose rate from natural radioactivity amounts to about 8 mrad/h. Male and female BALB/c mice (Mus musculus) were also placed in the hut during the summer period. The observations performed on those animals demonstrate that exposure to high natural radiation can increase the frequency of chromosome aberrations in somatic cells and indicate also that fertility in males and females is affected in an inverse manner. Model experiments with radon exposure of laboratory rabbits under controlled conditions have shown that the chromosome aberrations observed in somatic cells are not due to the radon exposure but essentially to gamma irradiation.

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