Lack of correlation between deoxyribonucleotide pool sizes, spontaneous mutation rates and malignant potential in Chinese hamster ovary cells

1989 ◽  
Vol 115 (5) ◽  
pp. 429-434
Author(s):  
Aaron Y. Tagger ◽  
Jacqueline E. Damen ◽  
Arnold H. Greenberg ◽  
Jim A. Wright
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Spontaneous Mutation ◽  
Chinese Hamster ◽  
Malignant Potential ◽  
Mutation Rates ◽  
Ovary Cells ◽  
Pool Sizes

Quantitative analysis of purine and pyrimidine metabolism in Chinese hamster ovary cells

1981 ◽  
Vol 59 (10) ◽  
pp. 838-847 ◽  
Author(s):  
Darel Hunting ◽  
Joyce Hordern ◽  
J. Frank Henderson
Keyword(s):  
Quantitative Analysis ◽  
Quantitative Study ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Pyrimidine Metabolism ◽  
Ovary Cells ◽  
Direct Measurements ◽  
Deoxyribonucleoside Triphosphate ◽  
Pool Sizes

A detailed quantitative study of purine and pyrimidine metabolism in logarithmically growing Chinese hamster ovary cells has been performed. Direct measurements of the ribonucleoside and deoxyribonucleoside triphosphate pool sizes have been made, and the pathways and rates of metabolism of adenine, hypoxanthine, guanine, guanosirae, deoxyadenosine, and deoxyguanosine and of uridine, cytidine, deoxyeytidine, deoxyuridine, and thymidine have been determined.

Malignancy-related characteristics of wild type and drug-resistant chinese hamster ovary cells

Pathology ◽  
1993 ◽  
Vol 25 (3) ◽  
pp. 268-276 ◽  
Author(s):  
Wanda B. Mackinnon ◽  
Marlen Dyne ◽  
Rebecca Hancock ◽  
Carolyn E. Mountford ◽  
Adrienne J. Grant ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Drug Resistant ◽  
Wild Type ◽  
Ovary Cells

Review of the current methods of Chinese Hamster Ovary (CHO) cells cultivation for production of therapeutic protein

2020 ◽  
Vol 17 ◽  
Author(s):  
Shazid Md. Sharker ◽  
Md. Atiqur Rahman
Keyword(s):  
Chinese Hamster Ovary ◽  
Cho Cells ◽  
Mass Production ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Therapeutic Protein ◽  
Specific Productivity ◽  
Ovary Cells ◽  
Further Development ◽  
Interesting Area

Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein. The developments of cell lines are possible to upgrade specific productivity. As a result, it holds an interesting area for academic as well as industrial researchers around the world. This review will concentrate on the recent progress of the mammalian CHO cells culture technology and the future scope of further development for the mass-production of protein therapeutics.

scholarly journals A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

2021 ◽  
pp. e00649
Author(s):  
Valerie Schmieder ◽  
Neža Novak ◽  
Heena Dhiman ◽  
Ly Ngoc Nguyen ◽  
Evgenija Serafimova ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells ◽  
Genomic Deletions
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