EDTA chelation and zinc antagonism with cadmium in sediment: effects on the behavior and mortality of two infaunal amphipods

1984 ◽  
Vol 84 (2) ◽  
pp. 125-130 ◽  
Author(s):  
J. M. Oakden ◽  
J. S. Oliver ◽  
A. R. Flegal
Keyword(s):  
Zinc Antagonism

Mechanism for cadmium and zinc antagonism of copper metabolism

1970 ◽  
Vol 40 (5) ◽  
pp. 1142-1148 ◽  
Author(s):  
G.W. Evans ◽  
Patrick F. Majors ◽  
W.E. Cornatzer
Keyword(s):  
Copper Metabolism ◽  
Zinc Antagonism

A novel effect of zinc on the lobster muscle GABA receptor

1982 ◽  
Vol 215 (1200) ◽  
pp. 327-341 ◽  
Keyword(s):  
Binding Site ◽  
Gaba Receptor ◽  
Divalent Cations ◽  
Chloride Conductance ◽  
Zinc Binding ◽  
Ph Titration ◽  
Zinc Binding Site ◽  
Conductance Increase ◽  
Cation Complex ◽  
Zinc Antagonism

The effect of zinc (and copper) was investigated on the lobster muscle γ-aminobutyric acid (GABA) receptor. Zinc (10 μm-1 mM) depressed the GABA-evoked conductance increase in a fully reversible manner by possibly binding to an imidazole group, suggested from pH titration studies on the evoked-chloride conductance. Other transition metal (period 4) divalent cations (up to 500 μM) were inactive in antagonizing GABA responses. Variation of external chloride or anion substitution did not perturb the zinc antagonism ; however, decreasing the pH markedly decreased the potency of zinc. A possible explanation for these results is discussed. Although the zinc antagonism resembled that produced by picrotoxinin, combination of these two agents depressed the GABA dose-conductance curve in a manner expected for two antagonists acting on independent sites. The zinc binding site was also discrete from the GABA recognition site; the results are interpreted in terms of a distinct binding site for zinc and H + . The distortion of an agonist dose-response curve by formation of an inactive agonist-divalent cation complex is discussed; however, complexation of GABA did not explain the observed antagonism by zinc. By comparison, zinc had no effect on the GABA responses of rat ganglionic neurons. It is concluded that the zinc binding site, on lobster muscle, may be an important modulatory site for the GABA-evoked chloride conductance.

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