Synergistic effects of nitrate and ammonium ion on the growth and uptake kinetics of Monochrysis lutheri in continuous culture

1976 ◽  
Vol 36 (1) ◽  
pp. 73-84 ◽  
Author(s):  
J. Caperon ◽  
D. A. Ziemann
Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 709
Author(s):  
Marta Jorba ◽  
Marina Pedrola ◽  
Ouldouz Ghashghaei ◽  
Rocío Herráez ◽  
Lluis Campos-Vicens ◽  
...  

This work reports a detailed characterization of the antimicrobial profile of two trimethoprim-like molecules (compounds 1a and 1b) identified in previous studies. Both molecules displayed remarkable antimicrobial activity, particularly when combined with sulfamethoxazole. In disk diffusion assays on Petri dishes, compounds 1a and 1b showed synergistic effects with colistin. Specifically, in combinations with low concentrations of colistin, very large increases in the activities of compounds 1a and 1b were determined, as demonstrated by alterations in the kinetics of bacterial growth despite only slight changes in the fractional inhibitory concentration index. The effect of colistin may be to increase the rate of antibiotic entry while reducing efflux pump activity. Compounds 1a and 1b were susceptible to extrusion by efflux pumps, whereas the inhibitor phenylalanine arginyl β-naphthylamide (PAβN) exerted effects similar to those of colistin. The interactions between the target enzyme (dihydrofolate reductase), the coenzyme nicotinamide adenine dinucleotide phosphate (NADPH), and the studied molecules were explored using enzymology tools and computational chemistry. A model based on docking results is reported.


Chemosphere ◽  
1998 ◽  
Vol 37 (2) ◽  
pp. 257-264 ◽  
Author(s):  
Jianlong Wang ◽  
Ping Liu ◽  
Hanchang Shi ◽  
Yi Qian

1990 ◽  
Vol 124 (2) ◽  
pp. 175-182 ◽  
Author(s):  
A. Jungk ◽  
C. J. Asher ◽  
D. G. Edwards ◽  
D. Meyer

2017 ◽  
Vol 65 (4) ◽  
pp. 333-339
Author(s):  
Tamiji Yamamoto ◽  
Tomoko Kishigami ◽  
Hikaru Nakagawa
Keyword(s):  

Extremophiles ◽  
2004 ◽  
Vol 8 (3) ◽  
pp. 185-192 ◽  
Author(s):  
Horia Banciu ◽  
Dimitry Y. Sorokin ◽  
Robbert Kleerebezem ◽  
Gerard Muyzer ◽  
Erwin A. Galinski ◽  
...  

Nanoscale ◽  
2014 ◽  
Vol 6 (13) ◽  
pp. 7325-7331 ◽  
Author(s):  
V. Hirsch ◽  
C. Kinnear ◽  
L. Rodriguez-Lorenzo ◽  
C. A. Monnier ◽  
B. Rothen-Rutishauser ◽  
...  

A well-controlled route towards biocompatible agglomerated Au-NPs is reported, which span the range from small particles with high diffusion coefficients to larger particles with lower diffusion coefficients. Difference in uptake kinetics of single NPs and agglomerates can be explained by particokinetics, without the need to consider size-mediated cellular uptake mechanisms.


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