The dosage-response curve for auxin-induced cell elongation: A reevaluation

Planta ◽  
1972 ◽  
Vol 104 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Robert Cleland
1974 ◽  
Vol 5 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Chukwuwetalu Ebenebe ◽  
Volkmar Von Bruchhausena ◽  
Friedrich Grossmann

1949 ◽  
Vol 90 (3) ◽  
pp. 233-253 ◽  
Author(s):  
H. C. Batson

A study of the effect of graded immunizing doses of typhoid vaccine and graded challenge doses of S. typhosa in 5 per cent mucin on the degree of gradation of response (survival or death) elicited in successive groups of mice is reported. In the range of doses employed the effect of graded immunizing doses was markedly greater than was the effect of graded challenge doses. Statistically the difference exceeded the 0.1 per cent level of significance. It was concluded that the use of graded immunizing doses was preferable to the use of graded challenge doses as a basis for the immunological assay of typhoid vaccine, since with the former there was obtained (a) a greater significance of differences in response of groups given graded doses even with smaller fold increments in successive doses, (b) a greater slope of the dosage-response curve which permitted estimation of ED50 values with smaller standard errors, and (c) an effect on response apparently less dependent on the sex of mice used.


1950 ◽  
Vol 220 (2) ◽  
pp. 156-159 ◽  
Author(s):  
Donald A. Clarke ◽  
Walter Modell ◽  
Theodore Greiner ◽  
Nathaniel T. Kwit ◽  
Joseph L. Gluck ◽  
...  

1947 ◽  
Vol 85 (1) ◽  
pp. 77-97 ◽  
Author(s):  
Oscar Hechter

The spreading response induced by intradermal administration of hyaluronidase is influenced not only by enzyme concentration, but also by the volume and pressure of the injection. These pressure-volume factors influence the rate of spreading and determine the final area of spreading. When a constant volume is injected, the rate of spreading to the area determined by the volume of injection is a function of the enzyme concentration. These and other findings have led to the conclusion that hyaluronidase is an effective spreading agent only when the slow diffusion of enzyme in skin is accelerated by a localized increase of interstitial pressure and volume. These considerations of hyaluronidase action in skin have been utilized to explain the shape of the dosage-response curve of hyaluronidase spreading activity, and the differences in the spreading reactions between crude snake venoms and purified hyaluronidase. The significance of the findings as related to the rôle of hyaluronidase in bacterial invasiveness, and in the assay of S. F. are briefly discussed.


Sign in / Sign up

Export Citation Format

Share Document