Time of Evaluation and the Dosage-Response Curve

1949 ◽  
Vol 42 (4) ◽  
pp. 579-585 ◽  
Author(s):  
Raimon L. Beard
Keyword(s):  
Response Curve ◽  
Dosage Response Curve

Dosage-response curve of wheat brown rust to triforine supplied via root treatment

1974 ◽  
Vol 5 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Chukwuwetalu Ebenebe ◽  
Volkmar Von Bruchhausena ◽  
Friedrich Grossmann
Keyword(s):  
Response Curve ◽  
Brown Rust ◽  
Dosage Response Curve ◽  
Root Treatment

scholarly journals THE RELATIVE SIGNIFICANCE OF GRADED IMMUNIZING AND CHALLENGE DOSES IN MEASURING THE POTENCY OF VACCINES

1949 ◽  
Vol 90 (3) ◽  
pp. 233-253 ◽  
Author(s):  
H. C. Batson
Keyword(s):  
Response Curve ◽  
Standard Errors ◽  
Typhoid Vaccine ◽  
Relative Significance ◽  
Immunological Assay ◽  
Cent Level ◽  
The Difference ◽  
Graded Challenge ◽  
Level Of Significance ◽  
Dosage Response Curve

A study of the effect of graded immunizing doses of typhoid vaccine and graded challenge doses of S. typhosa in 5 per cent mucin on the degree of gradation of response (survival or death) elicited in successive groups of mice is reported. In the range of doses employed the effect of graded immunizing doses was markedly greater than was the effect of graded challenge doses. Statistically the difference exceeded the 0.1 per cent level of significance. It was concluded that the use of graded immunizing doses was preferable to the use of graded challenge doses as a basis for the immunological assay of typhoid vaccine, since with the former there was obtained (a) a greater significance of differences in response of groups given graded doses even with smaller fold increments in successive doses, (b) a greater slope of the dosage-response curve which permitted estimation of ED50 values with smaller standard errors, and (c) an effect on response apparently less dependent on the sex of mice used.

THE DOSAGE-RESPONSE CURVE FOR THE COMPARISON OF MERCURIAL DIURETICS

1950 ◽  
Vol 220 (2) ◽  
pp. 156-159 ◽  
Author(s):  
Donald A. Clarke ◽  
Walter Modell ◽  
Theodore Greiner ◽  
Nathaniel T. Kwit ◽  
Joseph L. Gluck ◽  
...  
Keyword(s):  
Response Curve ◽  
Dosage Response Curve

scholarly journals STUDIES ON SPREADING FACTORS

1947 ◽  
Vol 85 (1) ◽  
pp. 77-97 ◽  
Author(s):  
Oscar Hechter
Keyword(s):  
Response Curve ◽  
Enzyme Concentration ◽  
Constant Volume ◽  
Interstitial Pressure ◽  
Snake Venoms ◽  
Slow Diffusion ◽  
Intradermal Administration ◽  
Dosage Response Curve

The spreading response induced by intradermal administration of hyaluronidase is influenced not only by enzyme concentration, but also by the volume and pressure of the injection. These pressure-volume factors influence the rate of spreading and determine the final area of spreading. When a constant volume is injected, the rate of spreading to the area determined by the volume of injection is a function of the enzyme concentration. These and other findings have led to the conclusion that hyaluronidase is an effective spreading agent only when the slow diffusion of enzyme in skin is accelerated by a localized increase of interstitial pressure and volume. These considerations of hyaluronidase action in skin have been utilized to explain the shape of the dosage-response curve of hyaluronidase spreading activity, and the differences in the spreading reactions between crude snake venoms and purified hyaluronidase. The significance of the findings as related to the rôle of hyaluronidase in bacterial invasiveness, and in the assay of S. F. are briefly discussed.

EXUDATE PRODUCED BY GLOMERELLA CINGULATA SPORES IN THE PRESENCE OF COPPER AND DITHIOCARBAMATE IONS

1962 ◽  
Vol 40 (1) ◽  
pp. 25-33 ◽  
Author(s):  
G. D. Thorn ◽  
L. T. Richardson
Keyword(s):  
Amino Acids ◽  
Glutamic Acid ◽  
Response Curve ◽  
Ternary Complex ◽  
Copper Ions ◽  
Aminobutyric Acid ◽  
Glomerella Cingulata ◽  
Egg Albumin ◽  
Reduced Toxicity ◽  
Dosage Response Curve

Small amounts of copper ions induce the release from spores of Glomerella cingulata Spauld. & Schrenk. of increased amounts of amino acids, predominantly glutamic acid, α-alanine, γ-aminobutyric acid, aspartic acid, glycine, leucine(s), and serine. Sodium dimethyldithiocarbamate, and copper in the form of the dimethyldithiocarbamate complex, do not show this effect. Added protein, such as egg albumin or cellulase, or the extracellular protein of spores suspended in water, forms a soluble ternary complex with dithiocarbamate and copper ions. This results in little or no loss of dithiocarbamate from solution and in reduced toxicity in the first mode of the dosage–response curve.

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