scholarly journals Cholecystokinin-stimulated enzyme secretion from dispersed rabbit pancreatic acinar cells: phosphorylation-dependent changes in potency and efficacy

1995 ◽  
Vol 430 (5) ◽  
pp. 626-635 ◽  
Author(s):  
P. H. G. M. Willems ◽  
S. E. Van Emst -de Vries ◽  
J. J. H. H. M. De Pont
Keyword(s):  
Acinar Cells ◽  
Enzyme Secretion ◽  
Pancreatic Acinar Cells

Messenger role of calcium in function of pancreatic acinar cells

1980 ◽  
Vol 239 (5) ◽  
pp. G335-G347
Author(s):  
I. Schulz
Keyword(s):  
Plasma Membrane ◽  
Acinar Cells ◽  
Enzyme Secretion ◽  
Pancreatic Acinar Cells ◽  
Free Calcium ◽  
Plasma Membrane Permeability ◽  
Cyclic Monophosphate ◽  
Free Calcium Concentration ◽  
Cytosolic Free Calcium Concentration ◽  
Group D

Enzyme secretion from the exocrine pancreas is elicited by a) cholinergic stimulants, b) hormones belonging to the family of pancreozymin, c) some amphibian peptides such as bombesin, eledoisin, and physalaemin, and d) secretin and vasoactive intestinal polypeptide. Whereas the mechanism of the group d hormones in stimulating enzyme secretion involves adenosine 3',5'-cyclic monophosphate, the others seem to use a common pathway involving Ca2+ as intracellular messenger and probably guanosine 3',5'-cyclic monophosphate as modulator of their action. Their effects can be ascribed to two processes. One pathway involves release of Ca2+ from an intracellular store that is most likely located in the plasma membrane. This phase is independent of extracellular Ca2+ and leads to a rise of guanosine 3',5'-cyclic monophosphate. The other pathway is characterized by an increased permeability of the plasma membrane for Ca2+ and is necessary for sustained secretion. Both pathways lead to an increase cytosolic-free Ca2+ concentration. Ca2+ is either directly involved in fusion of zymogen granules with the luminal cell membrane or triggers events that lead to exocytosis. Furthermore, augmented cytosolic-free calcium concentration a) increased the plasma membrane permeability for Na+, Cl-, and K+, which leads to depolarization of the cell, and b) induces uncoupling of neighboring acinar cells.

Prostaglandins and enzyme secretion from dispersed rat pancreatic acinar cells

Life Sciences ◽  
1979 ◽  
Vol 25 (11) ◽  
pp. 913-920 ◽  
Author(s):  
Laurence Chauvelot ◽  
Seymour Heisler ◽  
Jacques Huot ◽  
Denis Gagnon
Keyword(s):  
Acinar Cells ◽  
Enzyme Secretion ◽  
Pancreatic Acinar Cells

Role of tobacco vs alcohol, in intracellular calcium levels and enzyme secretion in pancreatic acinar cells

Pancreatology ◽  
2013 ◽  
Vol 13 (4) ◽  
pp. e14-e15
Author(s):  
M. Luaces-Regueira ◽  
M. Castiñeira-Alvariño ◽  
M. Castro-Manzanares ◽  
A. Carrascal-Miniño ◽  
M. Campos-Toimil ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Acinar Cells ◽  
Enzyme Secretion ◽  
Pancreatic Acinar Cells

Regulation of pancreatic exocrine secretion in vitro : the action of secretagogues

1981 ◽  
Vol 296 (1080) ◽  
pp. 17-26 ◽  
Keyword(s):  
Acinar Cells ◽  
Exocrine Secretion ◽  
Mechanisms Of Action ◽  
Enzyme Secretion ◽  
Pancreatic Acinar Cells ◽  
Wide Range ◽  
Pancreatic Exocrine ◽  
Final Effect ◽  
Stimulation Of

Pancreatic acinar cells possess two functionally distinct mechanisms by which secretagogues can increase enzyme secretion. One mechanism is mediated by mobilization of cellular calcium and can be activated by any one of four different classes of receptors. The other mechanism is mediated by cyclic AMP and can be activated by either of two different classes of receptors. In addition to stimulating enzyme secretion, a secretagogue can cause potentiation of secretion, desensitization to the subsequent stimulation caused by the same or other secretagogues as well as residual stimulation of enzyme secretion. Although each class of secretagogue receptors can cause the same final effect, stimulation of enzyme secretion, the existence of multiple classes of receptors and the different mechanisms of action endow the acinar cell with a wide range of patterns of response depending on which of the several classes of receptors are activated.

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