Effect of short-chain fatty acids on cell volume and intracellular pH in rat distal colon

1993 ◽  
Vol 424 (3-4) ◽  
pp. 216-223 ◽  
Author(s):  
M. Diener ◽  
C. Helmle-Kolb ◽  
H. Murer ◽  
E. Scharrer
Physiology ◽  
1999 ◽  
Vol 14 (2) ◽  
pp. 58-64 ◽  
Author(s):  
Joseph H. Sellin

Short-chain fatty acids are the predominant luminal anions in the colon (>75 mM) and thus create a rather unique environment for transporting epithelium. The colon absorbs short-chain fatty acids, either by diffusion of the protonated species across the apical membrane or by an anion exchange process with bicarbonate. Additionally, short-chain fatty acids modulate Na absorption, Cl secretion, intracellular pH, and cell volume.


2016 ◽  
Vol 12 (7) ◽  
pp. 637-646 ◽  
Author(s):  
Pittaya Chaikham ◽  
Arunee Apichartsrangkoon ◽  
Srivilai Worametrachanon ◽  
Tom Van de Wiele

Abstract The prospect of Lactobacillus casei 01 and pasteurized purple-rice drinks on modulating colon microbiome by using a simulator of the human intestinal microbial ecosystem was investigated. Accordingly, L. casei 01 alone and with pasteurized purple-rice drink were administered into the proximal and distal colons. In consequence, some colon bacteria and their metabolic activities were examined. The results showed that upon modulating the colon microbiota by L. casei 01 alone with pasteurized germinated-purple-rice drink in the distal colon, acetate and propionate (short-chain fatty acids) were equivalently elevated but other treatments performed differently. Based on the profile of colon microbiota, most treatments stimulated the highest number of lactobacilli followed by bifidobacteria, while other undesirable bacteria were moderately diminished. In overall, larger gelatinized starch in the rice drinks enabled by pasteurization triggered off better modulating impact than by pressurization.


PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0218118 ◽  
Author(s):  
Seiichiro Aoe ◽  
Chiemi Yamanaka ◽  
Miki Fuwa ◽  
Taiga Tamiya ◽  
Yasunori Nakayama ◽  
...  

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