Analysis of the age-related composition of human skin collagen and collagens synthesized by fibroblast culture

1994 ◽  
Vol 286 (7) ◽  
pp. 391-395 ◽  
Author(s):  
J. Brinckmann ◽  
M. Bodo ◽  
M. Brey ◽  
H. H. Wolff ◽  
P. K. M�ller
Keyword(s):  
Human Skin ◽  
Fibroblast Culture ◽  
Age Related ◽  
Skin Collagen

Age-related changes in human skin collagen galactosyltransferase and collagen glucosyltransferase activities

1977 ◽  
Vol 76 (1) ◽  
pp. 95-101 ◽  
Author(s):  
Henrik Anttinen ◽  
Aarne Oikarinen ◽  
Kari I. Kivirikko
Keyword(s):  
Human Skin ◽  
Age Related ◽  
Skin Collagen ◽  
Age Related Changes

Age-dependent accumulation of N.epsilon.-(carboxymethyl)lysine and N.epsilon.-(carboxymethyl)hydroxylysine in human skin collagen

Biochemistry ◽  
1991 ◽  
Vol 30 (5) ◽  
pp. 1205-1210 ◽  
Author(s):  
John A. Dunn ◽  
David R. McCance ◽  
Suzanne R. Thorpe ◽  
Timothy J. Lyons ◽  
John W. Baynes
Keyword(s):  
Human Skin ◽  
Skin Collagen ◽  
Age Dependent ◽  
Carboxymethyl Lysine

scholarly journals Age-related differences in human skin proteoglycans

Glycobiology ◽  
2010 ◽  
Vol 21 (2) ◽  
pp. 257-268 ◽  
Author(s):  
D. A. Carrino ◽  
A. Calabro ◽  
A. B. Darr ◽  
M. T. Dours-Zimmermann ◽  
J. D. Sandy ◽  
...  
Keyword(s):  
Human Skin ◽  
Age Related

scholarly journals In VivoAntioxidant and Anti-Skin-Aging Activities of Ethyl Acetate Extraction fromIdesia polycarpaDefatted Fruit Residue in Aging Mice Induced by D-Galactose

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Yang Ye ◽  
Ran-ran Jia ◽  
Lin Tang ◽  
Fang Chen
Keyword(s):  
Antioxidant Activity ◽  
Ethyl Acetate ◽  
Radical Scavenging ◽  
Antioxidant Defense System ◽  
Skin Aging ◽  
Age Related ◽  
Skin Collagen ◽  
Total Antioxidant ◽  
Mda Content

Two different concentrations of D-galactose (D-gal) induced organism and skin aging in Kunming mice were used to examine comprehensively the antioxidant and antiaging activities of ethyl acetate extraction (EAE) fromIdesia polycarpadefatted fruit residue for the first time. The oxygen radical absorbance capacity (ORAC) of EAE was 13.09 ± 0.11 μmol Trolox equivalents (TE)/mg, which showed EAE had greatin vitrofree radical scavenging and antioxidant activity. Biochemical indexes and morphological analysis of all tested tissues showed that EAE could effectively improve the total antioxidant capacity (T-AOC) of the antioxidant defense system of the aging mice, enhance the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) of tissues and serum, increase glutathione (GSH) content and decrease the malondialdehyde (MDA) content, and maintain the skin collagen, elastin, and moisture content. Meanwhile, EAE could effectively attenuate the morphological damage in brain, liver, kidney, and skin induced by D-gal and its effect was not less than that of the well-known L-ascorbic acid (VC) andα-tocopherol (VE). Overall, EAE is a potent natural antiaging agent with great antioxidant activity, which can be developed as a new medicine and cosmetic for the treatment of age-related conditions.

scholarly journals Transcriptomic analysis of human skin wound healing and rejuvenation following ablative fractional laser treatment

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260095
Author(s):  
Joseph D. Sherrill ◽  
Deborah Finlay ◽  
Robert L. Binder ◽  
Michael K. Robinson ◽  
Xingtao Wei ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wound Healing ◽  
Laser Treatment ◽  
Human Skin ◽  
Fractional Laser ◽  
Skin Rejuvenation ◽  
Skin Wound Healing ◽  
Age Related ◽  
Ablative Fractional Laser ◽  
Laser Treatments

Ablative fractional laser treatment is considered the gold standard for skin rejuvenation. In order to understand how fractional laser works to rejuvenate skin, we performed microarray profiling on skin biopsies to identify temporal and dose-response changes in gene expression following fractional laser treatment. The backs of 14 women were treated with ablative fractional laser (Fraxel®) and 4 mm punch biopsies were collected from an untreated site and at the treated sites 1, 3, 7, 14, 21 and 28 days after the single treatment. In addition, in order to understand the effect that multiple fractional laser treatments have on skin rejuvenation, several sites were treated sequentially with either 1, 2, 3, or 4 treatments (with 28 days between treatments) followed by the collection of 4 mm punch biopsies. RNA was extracted from the biopsies, analyzed using Affymetrix U219 chips and gene expression was compared between untreated and treated sites. We observed dramatic changes in gene expression as early as 1 day after fractional laser treatment with changes remaining elevated even after 1 month. Analysis of individual genes demonstrated significant and time related changes in inflammatory, epidermal, and dermal genes, with dermal genes linked to extracellular matrix formation changing at later time points following fractional laser treatment. When comparing the age-related changes in skin gene expression to those induced by fractional laser, it was observed that fractional laser treatment reverses many of the changes in the aging gene expression. Finally, multiple fractional laser treatments, which cover different regions of a treatment area, resulted in a sustained or increased dermal remodeling response, with many genes either differentially regulated or continuously upregulated, supporting previous observations that maximal skin rejuvenation requires multiple fractional laser treatments. In conclusion, fractional laser treatment of human skin activates a number of biological processes involved in wound healing and tissue regeneration.

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