Effect of growth supplements and whey pretreatment on butyric acid production by Clostridium butyricum

1995 ◽  
Vol 11 (3) ◽  
pp. 363-363 ◽  
Author(s):  
D. Vandák ◽  
M. Tomáška ◽  
J. Zigová ◽  
E. Šturdík
1999 ◽  
Vol 34 (8) ◽  
pp. 835-843 ◽  
Author(s):  
Jana Zigová ◽  
Ernest Šturdı́k ◽  
Dušan Vandák ◽  
Štefan Schlosser

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2792
Author(s):  
Yu-Ping Hsiao ◽  
Hsiao-Ling Chen ◽  
Jen-Ning Tsai ◽  
Meei-Yn Lin ◽  
Jiunn-Wang Liao ◽  
...  

Cisplatin-induced nephrotoxicity is associated with gut microbiota disturbance. The present study aimed to investigate whether supplementation of Lactobacillus reuteri and Clostridium butyricum (LCs) had a protective effect on cisplatin-induced nephrotoxicity through reconstruction of gut microbiota. Wistar rats were given different treatments: control, cisplatin (Cis), cisplatin + C. butyricum and L. reuteri (Cis+LCs), and C. butyricum and L. reuteri (LCs). We observed that cisplatin-treated rats supplemented with LCs exhibited significantly decreased renal inflammation (KIM-1, F4/80, and MPO), oxidative stress, fibrosis (collagen IV, fibronectin, and a-SMA), apoptosis, concentration of blood endotoxin and indoxyl sulfate, and increased fecal butyric acid production compared with those without supplementation. In addition, LCs improved the cisplatin-induced microbiome dysbiosis by maintaining a healthy gut microbiota structure and diversity; depleting Escherichia-Shigella and the Enterobacteriaceae family; and enriching probiotic Bifidobacterium, Ruminococcaceae, Ruminiclostridium_9, and Oscillibacter. Moreover, the LCs intervention alleviated the cisplatin-induced intestinal epithelial barrier impairment. This study indicated LCs probiotic serves as a mediator of the gut–kidney axis in cisplatin-induced nephrotoxicity to restore the intestinal microbiota composition, thereby suppressing uremic toxin production and enhancing butyrate production. Furthermore, the renoprotective effect of LCs is partially mediated by increasing the anti-inflammatory effects and maintaining the integrity of the intestinal barrier.


2018 ◽  
Vol 68 (6) ◽  
pp. 321-330
Author(s):  
Xin Wang ◽  
Jianzheng Li ◽  
Xue Chi ◽  
Yafei Zhang ◽  
Han Yan ◽  
...  

2020 ◽  
Vol 59 (39) ◽  
pp. 17147-17155 ◽  
Author(s):  
Hongxin Fu ◽  
Jialei Hu ◽  
Xiaolong Guo ◽  
Jun Feng ◽  
Yanan Zhang ◽  
...  

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