The morphology and location of atrial specific granules and the demonstration of atrial natriuretic factor in porcine, lapine and bovine heart by immunoelectronmicroscopy

1991 ◽  
Vol 15 (5) ◽  
pp. 335-340 ◽  
Author(s):  
M. Castagnaro ◽  
F. Guarda ◽  
M. L. Lucchi ◽  
R. Bortolami
Keyword(s):  
Atrial Natriuretic Factor ◽  
Bovine Heart ◽  
Natriuretic Factor ◽  
Specific Granules ◽  
Atrial Specific Granules ◽  
Atrial Natriuretic

Plasma Atrial Natriuretic Factor and Ultrastructure of Atrial Specific Granules Following Chronic Hypoxia in Rats

1987 ◽  
Vol 73 (s17) ◽  
pp. 26P-26P ◽  
Author(s):  
R J D Winter ◽  
L Meleagros ◽  
S Pervez ◽  
T Krausz ◽  
J M Polak ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Chronic Hypoxia ◽  
Natriuretic Factor ◽  
Specific Granules ◽  
Atrial Specific Granules ◽  
Atrial Natriuretic

Synthesis and renal activity of rat atrial granules depend on extracellular volume

1984 ◽  
Vol 247 (4) ◽  
pp. R750-R752
Author(s):  
U. Ackermann ◽  
T. G. Irizawa
Keyword(s):  
Atrial Natriuretic Factor ◽  
Extracellular Volume ◽  
Extracellular Fluid ◽  
Fluid Volume ◽  
Extracellular Fluid Volume ◽  
Deoxycorticosterone Acetate ◽  
Natriuretic Factor ◽  
Specific Granules ◽  
Atrial Specific Granules ◽  
Natriuretic Effect

Extracellular fluid volume (by 22Na) and extent of 4-h [3H]fucose incorporation into atrial-specific granules were measured in deoxycorticosterone acetate (DOCA)/salt-loaded or Na-deficient rats. The natriuretic potency of extracts from their atria was also measured in assay rats. DOCA/salt-treated animals had a significantly greater extracellular volume, a significantly greater degree of fucose uptake, and a significantly more potent diuretic and natriuretic effect than did Na-deficient rats. These observations, together with the known decrease in atrial granularity with DOCA treatment, suggest that a chronic increase in extracellular fluid volume is associated with increased synthesis and metabolism of atrial natriuretic factor. They also confirm the finding reported by others that granularity and natriuretic potency are not always directly related. It may be that visible granules represent a peptide storage form that requires further processing to become natriuretic.

Effect of a purified atrial natriuretic factor on rat and rabbit vascular strips and vascular beds

1984 ◽  
Vol 247 (1) ◽  
pp. R34-R39 ◽  
Author(s):  
R. Garcia ◽  
G. Thibault ◽  
M. Cantin ◽  
J. Genest
Keyword(s):  
Angiotensin Ii ◽  
Atrial Natriuretic Factor ◽  
Perfusion Pressure ◽  
Rat Kidney ◽  
Relaxant Effect ◽  
Natriuretic Factor ◽  
Specific Granules ◽  
Vascular Beds ◽  
Dose Dependent ◽  
Atrial Natriuretic

Rat atrium cardiocytes contain a powerful natriuretic and diuretic peptide that has been localized in the specific granules. This atrial natriuretic factor (ANF) produced a potent, dose-dependent relaxant effect on rabbit and rat arterial strips previously made to contract by application of either norepinephrine (NE) or angiotensin II. The effect was not seen if KCl was used as contractile agent or under any conditions with rabbit mesenteric strips. After the application of ANF the vascular strips were refractory to subsequent stimulation by either NE or angiotensin II. The infusion of ANF into a high-resistance isolated perfused rat kidney produced a rapid decrease (33 +/- 5 mmHg) in perfusion pressure that lasted for 18 +/- 3 min. This effect was not seen in the isolated rat mesenteric arterial preparation, even when the perfusion pressure was raised by the infusion of NE. These effects of ANF on vascular smooth muscle are not mediated by prostaglandins, by alpha- and beta-adrenergic and muscarinic receptors, or by an impairment of Ca2+ influx, but they are mimicked by sodium nitroprusside. A low- and a high-molecular-weight ANF produced the same effects. The existence of specific receptive sites for these peptides is suggested.

Atrial Natriuretic Factor Receptors

1987 ◽  
Vol 16 (1) ◽  
pp. 63-77 ◽  
Author(s):  
John W. Jacobs ◽  
George P. Vlasuk ◽  
Michael Rosenblatt
Keyword(s):  
Atrial Natriuretic Factor ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Acute and chronic sodium loading stimulates atrial natriuretic factor (ANF) in man

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S165-S166 ◽  
Author(s):  
G. WAMBACH ◽  
S. GÖTZ ◽  
G. SUCKAU ◽  
G. BÖNNER ◽  
W. KAUFMANN
Keyword(s):  
Atrial Natriuretic Factor ◽  
Natriuretic Factor ◽  
Sodium Loading ◽  
Atrial Natriuretic
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