Comparative studies on the effect of fenbendazole on the liver and liver microsomal enzymes in goats, quail and rats

1989 ◽  
Vol 13 (2) ◽  
pp. 135-139 ◽  
Author(s):  
R. R. Dalvi
Keyword(s):  
Comparative Studies ◽  
Microsomal Enzymes ◽  
Liver Microsomal Enzymes

Role of estrogens in phenobarbital induction of liver microsomal enzymes

1975 ◽  
Vol 80 (3) ◽  
pp. 1043-1045
Author(s):  
P. V. Sergeev ◽  
N. N. Vedernikova ◽  
A. I. Maiskii ◽  
N. V. Shapoval ◽  
V. A. Volov
Keyword(s):  
Microsomal Enzymes ◽  
Phenobarbital Induction ◽  
Liver Microsomal Enzymes

Effect of Splenectomy on the Activity of Drug-Metabolizing Enzymes in the Liver of Rats

1971 ◽  
Vol 49 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Jules Brodeur ◽  
Claude Marchand
Keyword(s):  
Indirect Evidence ◽  
Female Rats ◽  
Microsomal Enzymes ◽  
Drug Metabolizing Enzyme ◽  
Effect Of Splenectomy ◽  
Maximal Induction ◽  
Metabolizing Enzyme ◽  
Cytochrome P 450 ◽  
Liver Microsomal Enzymes

Splenectomy was performed in adult female rats in order to investigate the influence of removal of the spleen on liver microsomal enzymes and cytochrome P-450 in vitro, as well as on the pharmacological activity of certain drugs in intact animals. Splenectomy significantly decreases the amount of cytochrome P-450 at 1 and 4 days after the operation, but not at 7 days. The activity of the enzymes catalyzing the metabolism of parathion, p-nitroanisole, and zoxazolamine is also decreased 4 days after splenectomy, whereas that of the enzymes involved in the metabolism of hexobarbital is unchanged. The maximal induction by phenobarbital of the enzymatic activities catalyzing the metabolism of parathion, p-nitroanisole, and zoxazolamine is prevented by splenectomy. Splenectomy exerts very little effect on plasma levels of hexobarbital and hexobarbital sleeping time; however, in both control and phenobarbital-pretreated rats, splenectomy results in a marked increase in the duration of zoxazolamine paralysis. These results indicate that splenectomy exerts inhibitory effects on certain liver microsomal enzymes, and provide some indirect evidence in support of the view that the hepatic blood supply is important for maintaining normal levels of drug-metabolizing enzyme activity in the liver.

Effects of methylmercury hydroxide on rat liver microsomal enzymes

1972 ◽  
Vol 4 (4) ◽  
pp. 265-280 ◽  
Author(s):  
G. Lucier ◽  
O. McDaniel ◽  
P. Brubaker ◽  
R. Klein
Keyword(s):  
Rat Liver ◽  
Microsomal Enzymes ◽  
Liver Microsomal Enzymes

scholarly journals Activity of liver microsomal enzymes during the chronic phase of murine schistosomiasis

2007 ◽  
Vol 40 (5) ◽  
pp. 657-662 ◽  
Author(s):  
F.P. Conte ◽  
A.A. Fidalgo-Neto ◽  
D.A. Manhães-Rocha ◽  
F.J.R. Paumgartten ◽  
A.C.A.X. De-Oliveira
Keyword(s):  
Chronic Phase ◽  
Microsomal Enzymes ◽  
Liver Microsomal Enzymes

THE EFFECT OF ANTICONVULSANT DRUGS WHICH INDUCE LIVER MICROSOMAL ENZYMES ON DERIVED AND INGESTED PHENOBARBITONE LEVELS

2009 ◽  
Vol 56 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Noel Callaghan ◽  
Morgan Feely ◽  
Finbar Duggan ◽  
Michael O'callaghan ◽  
J. Seldrup
Keyword(s):  
Anticonvulsant Drugs ◽  
Microsomal Enzymes ◽  
Liver Microsomal Enzymes

Inhibitory effects of beryllium chloride on rat liver microsomal enzymes

Toxicology ◽  
1990 ◽  
Vol 61 (3) ◽  
pp. 293-301 ◽  
Author(s):  
Catarina F.P. Teixeira ◽  
Wilson J. Yasaka ◽  
Luiziana F. Silva ◽  
Tereza T. Oshiro ◽  
Seizi Oga
Keyword(s):  
Rat Liver ◽  
Inhibitory Effects ◽  
Microsomal Enzymes ◽  
Beryllium Chloride ◽  
Liver Microsomal Enzymes
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