Role of estrogens in phenobarbital induction of liver microsomal enzymes

1975 ◽  
Vol 80 (3) ◽  
pp. 1043-1045
Author(s):  
P. V. Sergeev ◽  
N. N. Vedernikova ◽  
A. I. Maiskii ◽  
N. V. Shapoval ◽  
V. A. Volov
Keyword(s):  
Microsomal Enzymes ◽  
Phenobarbital Induction ◽  
Liver Microsomal Enzymes

scholarly journals ON THE RELATIONSHIP OF LIVER GLUCOSE-6-PHOSPHATASE TO THE PROLIFERATION OF ENDOPLASMIC RETICULUM IN PHENOBARBITAL INDUCTION

1966 ◽  
Vol 31 (2) ◽  
pp. 243-256 ◽  
Author(s):  
Sten Orrenius ◽  
Jan L. E. Ericsson
Keyword(s):  
Endoplasmic Reticulum ◽  
Phosphatase Activity ◽  
Actinomycin D ◽  
Microsomal Enzymes ◽  
High Drug ◽  
Histochemical Methods ◽  
Relationship Of ◽  
The Relationship ◽  
Phenobarbital Induction ◽  
Liver Microsomal Enzymes

The differentiated effects of phenobarbital treatment on liver microsomal enzymes have been further studied. The relationship between the resulting decrease in the specific glucose-6-phosphatase activity and the enhancement of formation of endoplasmic reticulum membranes with high drug-hydroxylating activity has been investigated with biochemical and histochemical methods. Biochemically and histochemically demonstrable glucose-6-phosphatase activity was found to be present in all endoplasmic reticulum membranes, including the phenobarbital-induced smooth-surfaced proliferates, even though there was an over-all decrease in activity. Actinomycin D did not inhibit the decrease in glucose-6-phosphatase activity. The findings are discussed with reference to the enzyme-membrane relationship in phenobarbital induction.

The role of liver microsomal enzymes in the metabolism of parathion

1973 ◽  
Vol 22 (23) ◽  
pp. 2943-2946 ◽  
Author(s):  
Neško Nešković ◽  
Slavoljub Vitorović ◽  
Marijana PlesniČar
Keyword(s):  
Microsomal Enzymes ◽  
Liver Microsomal Enzymes

Effect of Splenectomy on the Activity of Drug-Metabolizing Enzymes in the Liver of Rats

1971 ◽  
Vol 49 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Jules Brodeur ◽  
Claude Marchand
Keyword(s):  
Indirect Evidence ◽  
Female Rats ◽  
Microsomal Enzymes ◽  
Drug Metabolizing Enzyme ◽  
Effect Of Splenectomy ◽  
Maximal Induction ◽  
Metabolizing Enzyme ◽  
Cytochrome P 450 ◽  
Liver Microsomal Enzymes

Splenectomy was performed in adult female rats in order to investigate the influence of removal of the spleen on liver microsomal enzymes and cytochrome P-450 in vitro, as well as on the pharmacological activity of certain drugs in intact animals. Splenectomy significantly decreases the amount of cytochrome P-450 at 1 and 4 days after the operation, but not at 7 days. The activity of the enzymes catalyzing the metabolism of parathion, p-nitroanisole, and zoxazolamine is also decreased 4 days after splenectomy, whereas that of the enzymes involved in the metabolism of hexobarbital is unchanged. The maximal induction by phenobarbital of the enzymatic activities catalyzing the metabolism of parathion, p-nitroanisole, and zoxazolamine is prevented by splenectomy. Splenectomy exerts very little effect on plasma levels of hexobarbital and hexobarbital sleeping time; however, in both control and phenobarbital-pretreated rats, splenectomy results in a marked increase in the duration of zoxazolamine paralysis. These results indicate that splenectomy exerts inhibitory effects on certain liver microsomal enzymes, and provide some indirect evidence in support of the view that the hepatic blood supply is important for maintaining normal levels of drug-metabolizing enzyme activity in the liver.

Effects of methylmercury hydroxide on rat liver microsomal enzymes

1972 ◽  
Vol 4 (4) ◽  
pp. 265-280 ◽  
Author(s):  
G. Lucier ◽  
O. McDaniel ◽  
P. Brubaker ◽  
R. Klein
Keyword(s):  
Rat Liver ◽  
Microsomal Enzymes ◽  
Liver Microsomal Enzymes
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