Signals controlling alternative splicing of major histocompatibility complex H-2 class I pre-mRNA

1988 ◽  
Vol 28 (2) ◽  
pp. 81-90 ◽  
Author(s):  
Diane E. Handy ◽  
James McCluskey ◽  
Andrew M. Lew ◽  
John E. Coligan ◽  
David H. Margulies
Keyword(s):  
Major Histocompatibility Complex ◽  
Alternative Splicing ◽  
Class I ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates

Genetics ◽  
2004 ◽  
Vol 166 (4) ◽  
pp. 1897-1907
Author(s):  
Hiromi Sawai ◽  
Yoshi Kawamoto ◽  
Naoyuki Takahata ◽  
Yoko Satta
Keyword(s):  
Major Histocompatibility Complex ◽  
Distinct Group ◽  
Gene Organization ◽  
Class I ◽  
Phylogenetic Position ◽  
Specific Gene ◽  
New World Monkeys ◽  
Major Histocompatibility ◽  
Nucleotide Substitutions ◽  
Histocompatibility Complex

Abstract New World monkeys (NWMs) occupy a critical phylogenetic position in elucidating the evolutionary process of major histocompatibility complex (MHC) class I genes in primates. From three subfamilies of Aotinae, Cebinae, and Atelinae, the 5′-flanking regions of 18 class I genes are obtained and phylogenetically examined in terms of Alu/LINE insertion elements as well as the nucleotide substitutions. Two pairs of genes from Aotinae and Atelinae are clearly orthologous to human leukocyte antigen (HLA) -E and -F genes. Of the remaining 14 genes, 8 belong to the distinct group B, together with HLA-B and -C, to the exclusion of all other HLA class I genes. These NWM genes are classified into four groups, designated as NWM-B1, -B2, -B3, and -B4. Of these, NWM-B2 is orthologous to HLA-B/C. Also, orthologous relationships of NWM-B1, -B2, and -B3 exist among different families of Cebidae and Atelidae, which is in sharp contrast to the genus-specific gene organization within the subfamily Callitrichinae. The other six genes belong to the distinct group G. However, a clade of these NWM genes is almost equally related to HLA-A, -J, -G, and -K, and there is no evidence for their orthologous relationships to HLA-G. It is argued that class I genes in simian primates duplicated extensively in their common ancestral lineage and that subsequent evolution in descendant species has been facilitated mainly by independent loss of genes.

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