Cytoskeletal changes accompanying ACTH-induced steroidogenesis in cultured embryonic adrenal gland cells from the Pekin duck

1992 ◽  
Vol 268 (1) ◽  
pp. 157-165 ◽  
Author(s):  
James Cronshaw ◽  
B. K. Reese ◽  
M. A. Collie ◽  
W. N. Holmes
Keyword(s):  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hubert Stangl ◽  
Anita Krammetsvogl ◽  
Martin Lesiak ◽  
Christine Wolff ◽  
Rainer H. Straub

Abstract In experimental arthritis, glucocorticoid secretion is inadequate relative to inflammation. We hypothesized that IL-1 is a key factor for inadequate glucocorticoid secretion in arthritic rats. Collagen type II—induced arthritis (CIA) in DA rats was the model to study effects of IL-1 on adrenal function. In the CIA model, an increase of intraadrenal MHCII-positive cells was observed. MHCII-positive cells or bone marrow-derived dendritic cells inhibited glucocorticoid secretion of adrenal gland cells. IL-1, but also IL-18 and the inflammasome were critical in glucocorticoid inhibition. Arthritic compared to control adrenal gland cells produced higher amounts of CXC chemokines from MHCII+ adrenal cells, particularly CINC-2, which is strongly dependent on presence of IL-1. In CIA, macrophages and/or dendritic cells inhibit glucocorticoid secretion via IL-1 in adrenal glands. These findings show that activated macrophages and/or dendritic cells inhibit glucocorticoid secretion in experimental arthritis and that IL-1β is a decisive factor.


2007 ◽  
Vol 566 (1-3) ◽  
pp. 226-230 ◽  
Author(s):  
Jun-ichi Birumachi ◽  
Masami Hiroyama ◽  
Yoko Fujiwara ◽  
Toshinori Aoyagi ◽  
Atsushi Sanbe ◽  
...  

2008 ◽  
Vol 79 (3) ◽  
pp. 470-473 ◽  
Author(s):  
M. A. SALAS ◽  
S. W. EVANS ◽  
M. J. LEVELL ◽  
J. T. WHICHER

Sign in / Sign up

Export Citation Format

Share Document