Correlation between steroid hormone receptors and response to medroxyprogesterone acetate therapy in renal cell carcinoma: results of a long-term study

1989 ◽  
Vol 6 (4) ◽  
pp. 250-254
Author(s):  
E. Bercovich ◽  
M. Lo Cigno ◽  
M. Soli ◽  
R. Beghelli ◽  
F. Montanari ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Medroxyprogesterone Acetate ◽  
Renal Cell ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Term Study ◽  
Long Term Study

Clinical aspects of steroid hormone receptors in human renal cell carcinoma

1983 ◽  
Vol 23 (2) ◽  
pp. 117-124 ◽  
Author(s):  
James P. Karr ◽  
J. Edson Pontes ◽  
Sara Schneider ◽  
Avery A. Sandberg ◽  
Gerald P. Murphy
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Clinical Aspects ◽  
Human Renal Cell Carcinoma

Clinical Aspects of Steroid Hormone Receptors in Human Renal Cell Carcinoma

1984 ◽  
Vol 131 (1) ◽  
pp. 179-179
Author(s):  
J.P. Karr ◽  
J.E. Pontes ◽  
S. Schneider ◽  
A.A. Sandberg ◽  
G.P. Murphy
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Clinical Aspects ◽  
Human Renal Cell Carcinoma

Prognostic Value of the VHL, HIF-1α, and VEGF Signaling Pathway and Associated MAPK (ERK1/2 and ERK5) Pathways in Clear-Cell Renal Cell Carcinoma. A Long-Term Study

2017 ◽  
Vol 15 (6) ◽  
pp. e923-e933 ◽  
Author(s):  
Antonio S. Salinas-Sánchez ◽  
Leticia Serrano-Oviedo ◽  
Syongh Y. Nam-Cha ◽  
Olga Roche-Losada ◽  
Ricardo Sánchez-Prieto ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Value ◽  
Clear Cell ◽  
Term Study ◽  
Cell Renal Cell Carcinoma ◽  
Vegf Signaling ◽  
Long Term Study ◽  
Vegf Signaling Pathway

1103: Long-Term Survival Following Nephrectomy for Renal Cell Carcinoma: The 15 Year UCLA Experience

2006 ◽  
Vol 175 (4S) ◽  
pp. 355-355
Author(s):  
Manuel Eisenberg ◽  
John S. Lam ◽  
Rakhee H. Goel ◽  
Allan J. Pantuck ◽  
Robert A. Figlin ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Long-term progression-free survival of patients with metastatic melanoma or renal cell carcinoma following high-dose interleukin-2

2021 ◽  
Vol 69 (4) ◽  
pp. 888-892
Author(s):  
Joseph I Clark ◽  
Brendan Curti ◽  
Elizabeth J Davis ◽  
Howard Kaufman ◽  
Asim Amin ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Melanoma ◽  
Systemic Therapy ◽  
Renal Cell ◽  
Interleukin 2 ◽  
Progression Free Survival ◽  
High Dose ◽  
Free Survival

High-dose interleukin-2 (HD IL-2) was approved in the 1990s after demonstrating durable complete responses (CRs) in some patients with metastatic melanoma (mM) and metastatic renal cell carcinoma (mRCC). Patients who achieve this level of disease control have also demonstrated improved survival compared with patients who progress, but limited data are available describing the long-term course. The aim of this study was to better characterize long-term survival following successful HD IL-2 treatment in patients with no subsequent systemic therapy. Eleven HD IL-2 treatment centers identified patients with survival ≥5 years after HD IL-2, with no subsequent systemic therapy. Survival was evaluated from the date of IL-2 treatment to June 2017. Treatment courses consisted of 2 1-week cycles of HD IL-2. Patients were treated with HD IL-2 alone, or HD IL-2 followed by local therapy to achieve maximal response. 100 patients are reported: 54 patients with mM and 46 patients with mRCC. Progression-free survival (PFS) after HD IL-2 ranges from 5+ years to 30+ years, with a median follow-up of 10+ years. 27 mRCC and 32 mM are alive ≥10 years after IL-2. Thus, a small subset of patients with mM and mRCC achieve long-term PFS (≥5 years) after treatment with HD IL-2 as their only systemic therapy. The ability of HD IL-2 therapy to induce prolonged PFS should be a major consideration in studies of new immunotherapy combinations for mM and mRCC.

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