Vagotomy induced changes in acetyl cholinesterase staining and substance P-like immunoreactivity in the gustatory lobes of goldfish

1984 ◽  
Vol 170 (3) ◽  
pp. 257-264 ◽  
Author(s):  
Thomas E. Finger
Keyword(s):  
Substance P ◽  
Acetyl Cholinesterase ◽  
Induced Changes

Stress-Induced Changes in Cholecystokinin and Substance P Concentrations in Discrete Regions of the Rat Hypothalamus

1987 ◽  
Vol 46 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Richard A. Siegel ◽  
Eva-Maria Düker ◽  
Ulrich Pahnke ◽  
Wolfgang Wuttke
Keyword(s):  
Substance P ◽  
Rat Hypothalamus ◽  
Induced Changes

Neuropeptides degranulate serous cells of ferret tracheal glands

1986 ◽  
Vol 251 (2) ◽  
pp. C223-C229 ◽  
Author(s):  
A. A. Gashi ◽  
D. B. Borson ◽  
W. E. Finkbeiner ◽  
J. A. Nadel ◽  
C. B. Basbaum
Keyword(s):  
Substance P ◽  
Gland Cell ◽  
Secretory Granules ◽  
Light And Electron Microscopy ◽  
Base Line ◽  
Mucous Cells ◽  
Percent Change ◽  
Submucosal Glands ◽  
Muscarinic Cholinergic ◽  
Induced Changes

To determine whether serous or mucous cells in tracheal submucosal glands respond to the neuropeptides substance P (SP) and vasoactive intestinal peptide (VIP), we studied the peptide-induced changes in gland cell morphology accompanying release of 35SO4-labeled macromolecules from tracheal explants of ferrets. Explants were labeled for 1 h in medium containing 35SO4 and washed for 3.5 additional hours. Base-line secretion in the absence of drugs declined between 1.5 and 3.5 h after the pulse. Between 2.5 and 3.5 h, the average percent change in counts per minute recovered per sample period was not significantly different from zero (P greater than 0.3; n = 6). Substance P (10(-5) M) and VIP (2 X 10(-6) M) added 4 h after labeling each increased greatly the release of 35SO4-labeled macromolecules (SP, 219%; VIP, 180%) above base line. Bethanechol, a muscarinic-cholinergic agonist (10(-5) M), increased secretion by an average of 142% above base line (each effect, P less than 0.05; n = 6 each). Light and electron microscopy of the control tissues showed glands with narrow lumens and numerous secretory granules. Glands treated with SP or VIP had enlarged lumens and the serous cells were markedly degranulated. These phenomena were documented by morphometry and suggest that SP and VIP cause secretion from glands at least partially by stimulating exocytosis from serous cells.

Substance P-Induced Changes in Kidney Function in the Conscious Rat: Relation to the Renal Prostaglandin System

1983 ◽  
Vol 6 (1) ◽  
pp. 10-18 ◽  
Author(s):  
Herbert J. Kramer ◽  
Dietrich Klingmüller ◽  
Frank A. Flachskampf ◽  
Rainer Düsing
Keyword(s):  
Substance P ◽  
Kidney Function ◽  
Conscious Rat ◽  
Induced Changes ◽  
Prostaglandin System

SUBSTANCE P INDUCED CHANGES IN CD74 AND CD44 IN THE RAT BLADDER

2005 ◽  
Vol 173 (2) ◽  
pp. 615-620 ◽  
Author(s):  
KATHERINE L. MEYER-SIEGLER ◽  
PEDRO L. VERA
Keyword(s):  
Substance P ◽  
Rat Bladder ◽  
Induced Changes

Postnatal changes in gut hemodynamics: a possible role for substance P

1998 ◽  
Vol 274 (6) ◽  
pp. G1142-G1150 ◽  
Author(s):  
Philip T. Nowicki
Keyword(s):  
Substance P ◽  
Vascular Resistance ◽  
Mesenteric Artery ◽  
Benzyl Ester ◽  
Dependent Manner ◽  
Vascular Effect ◽  
Mechanical Removal ◽  
Induced Changes

Studies were conducted in young postnatal swine to determine if substance P (SP) participates in the regulation of postnatal intestinal hemodynamics and oxygenation. SP was present in homogenates of whole intestine from postnatal swine in an age-dependent manner as follows: 1 day old and never fed, 126 ± 35; 3 days old and fasted, 148 ± 30; and 14 days old, 51 ± 10 pg/mg protein ( P < 0.01, 14- vs. 1- or 3-day-olds). Phenylephrine-precontracted rings of mesenteric artery from 3-day-old subjects mounted for tension recording within buffer-filled myographs demonstrated brisk relaxation in response to SP (EC50, 2 × 10−10 M). This relaxation was eliminated by mechanical removal of the endothelium or blockade with the l-arginine analog N G-monomethyl-l-arginine (l-NMMA) and was significantly attenuated by pretreatment with N-acyl-l-Trp-3,5-bis-(trifluoromethyl) benzyl ester (NATB), a highly selective NK-1 receptor antagonist (pA2 5 × 10−10 M). Infusion of exogenous SP into the mesenteric artery of innervated in vivo gut loops reduced intestinal vascular resistance 35% and increased tissue oxygen uptake 40% in both 3- and 14-day-old subjects. By contrast, blockade of the NK-1 receptor for SP with NATB increased intestinal vascular resistance 19% in 3-day-old subjects but only 5% in 14-day-old subjects ( P < 0.01). SP-induced changes in gut vascular resistance were significantly attenuated by prior coinfusion of NATB orl-NMMA, indicating that the peptide exerted this vascular effect via the NK-1 receptor, which is linked to endothelial cell nitric oxide synthase. Both NATB andl-NMMA attenuated flow-induced dilation within pump-perfused in vitro gut loops from 3-day-old subjects. SP appears to participate in the regulation of the newborn intestinal circulation, especially during the first days after birth.

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