Spatial and biological characterisation of the complete quinic acid utilisation gene cluster in Aspergillus nidulans

1990 ◽  
Vol 223 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Heather K. Lamb ◽  
Alastair R. Hawkins ◽  
Melanie Smith ◽  
Ian J. Harvey ◽  
John Brown ◽  
...  
Keyword(s):  
Aspergillus Nidulans ◽  
Gene Cluster ◽  
Quinic Acid

scholarly journals Selective overexpression of the QUTE gene encoding catabolic 3-dehydroquinase in multicopy transformants of Aspergillus nidulans

1990 ◽  
Vol 265 (2) ◽  
pp. 337-342 ◽  
Author(s):  
R K Beri ◽  
S Grant ◽  
C F Roberts ◽  
M Smith ◽  
A R Hawkins
Keyword(s):  
Chlorogenic Acid ◽  
Aspergillus Nidulans ◽  
Gene Cluster ◽  
Quinic Acid ◽  
The Other ◽  
Gene Encoding ◽  
Repressor Gene ◽  
Catabolic Enzymes ◽  
Multiple Copies

The three enzymes necessary to catabolize quinate to protocatechuate are inducible by quinic acid, and transcription of their corresponding genes is controlled by the action of a positively acting activator gene and a negatively acting repressor gene. Transformed strains of Aspergillus nidulans containing multiple copies of the activator gene (QUTA) but single copies of the other QUT genes retain normal regulation of the gene cluster and do not show any overexpression of the three quinic acid catabolic enzymes. Transformed strains containing equal multiple copies of the activator gene (QUTA) and QUTE (encoding catabolic 3-dehydroquinase), but single copies of the other QUT genes, retain normal regulation of the QUT gene cluster, but selectively overexpress the QUTE gene upon quinic acid induction. Data are presented that strongly suggested that the gene QUTG, which is physically located within the QUT gene cluster and for which no function has been identified, is not required for expression of the gene cluster and does not encode a chlorogenic acid esterase.

Molecular organisation of the quinic acid utilization (QUT) gene cluster in Aspergillus nidulans

1988 ◽  
Vol 214 (2) ◽  
pp. 224-231 ◽  
Author(s):  
Alastair R. Hawkins ◽  
Heather K. Lamb ◽  
Melanie Smith ◽  
John W. Keyte ◽  
Clive F. Roberts
Keyword(s):  
Aspergillus Nidulans ◽  
Gene Cluster ◽  
Quinic Acid ◽  
Molecular Organisation

scholarly journals Genetic Regulation of the Quinic Acid Utilization (QUT) Gene Cluster in Aspergillus nidulans

Microbiology ◽  
1988 ◽  
Vol 134 (2) ◽  
pp. 347-358 ◽  
Author(s):  
S. GRANT ◽  
C. F. ROBERTS ◽  
H. LAMB ◽  
M. STOUT ◽  
A. R. HAWKINS
Keyword(s):  
Aspergillus Nidulans ◽  
Gene Cluster ◽  
Genetic Regulation ◽  
Quinic Acid

scholarly journals Evidence for Two Control Genes Regulating Expression of the Quinic Acid Utilization (qut) Gene Cluster in Aspergillus nidulans

Microbiology ◽  
1984 ◽  
Vol 130 (3) ◽  
pp. 567-574
Author(s):  
A. R. HAWKINS ◽  
A. J. FRANCISCO DA SILVA ◽  
C. F. ROBERTS
Keyword(s):  
Aspergillus Nidulans ◽  
Gene Cluster ◽  
Quinic Acid

Identification and isolation of a putative permease gene in the quinic acid utilization (QUT) gene cluster of Aspergillus nidulans

1987 ◽  
Vol 12 (2) ◽  
pp. 135-139 ◽  
Author(s):  
Hayley A. Whittington ◽  
Susan Grant ◽  
Clive F. Roberts ◽  
Heather Lamb ◽  
Alastair R. Hawkins
Keyword(s):  
Aspergillus Nidulans ◽  
Gene Cluster ◽  
Quinic Acid
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