Changes in carotid flow velocity induced by lowering cerebrospinal fluid pressure in normal pressure hydrocephalus

1978 ◽  
Vol 218 (1) ◽  
pp. 17-22 ◽  
Author(s):  
H. C. Schoonderwaldt ◽  
E. Colon ◽  
O. R. Hommes ◽  
W. A. C. Schijns
Keyword(s):  
Cerebrospinal Fluid ◽  
Flow Velocity ◽  
Normal Pressure Hydrocephalus ◽  
Fluid Pressure ◽  
Normal Pressure ◽  
Cerebrospinal Fluid Pressure ◽  
Carotid Flow

Normal pressure hydrocephalus. Influences on cerebral hemodynamic and cerebrospinal fluid pressure-chemical autoregulation

1984 ◽  
Vol 21 (2) ◽  
pp. 195-203 ◽  
Author(s):  
John S. Meyer ◽  
Hisao Tachibana ◽  
Jeffrey P. Hardenberg ◽  
Richard E. Dowell ◽  
Yasuhisa Kitagawa ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Normal Pressure Hydrocephalus ◽  
Fluid Pressure ◽  
Normal Pressure ◽  
Cerebrospinal Fluid Pressure ◽  
Cerebral Hemodynamic ◽  
Pressure Chemical

scholarly journals Quantitative Analysis of Cerebrospinal Fluid Pressure Gradients in Healthy Volunteers and Patients with Normal Pressure Hydrocephalus

2015 ◽  
Vol 55 (8) ◽  
pp. 657-662 ◽  
Author(s):  
Naokazu HAYASHI ◽  
Mitsunori MATSUMAE ◽  
Satoshi YATSUSHIRO ◽  
Akihiro HIRAYAMA ◽  
Afnizanfaizal ABDULLAH ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Quantitative Analysis ◽  
Healthy Volunteers ◽  
Normal Pressure Hydrocephalus ◽  
Fluid Pressure ◽  
Normal Pressure ◽  
Cerebrospinal Fluid Pressure ◽  
Pressure Gradients

Cerebral blood flow velocity and cerebrospinal fluid pressure after single bolus of propofol

1989 ◽  
Vol 11 (3) ◽  
pp. 150-151 ◽  
Author(s):  
A. Parma ◽  
R. Massei ◽  
A. Pesenti ◽  
C. Ferrari da Passano ◽  
G. Gran ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebrospinal Fluid ◽  
Cerebral Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Cerebral Blood Flow Velocity ◽  
Fluid Pressure ◽  
Cerebrospinal Fluid Pressure ◽  
Single Bolus

scholarly journals Normal-Pressure Hydrocephalus: Is There a Genetic Predisposition?

2011 ◽  
Vol 38 (2) ◽  
pp. 274-281 ◽  
Author(s):  
M. D. Cusimano ◽  
D. Rewilak ◽  
D. T. Stuss ◽  
J. C. Barrera-Martinez ◽  
F. Salehi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Urinary Incontinence ◽  
Cognitive Impairment ◽  
Environmental Factors ◽  
Natural History ◽  
Normal Pressure Hydrocephalus ◽  
Genetic Predisposition ◽  
Fluid Pressure ◽  
Cerebral Atrophy ◽  
Normal Pressure

Background:Normal-pressure hydrocephalus (NPH) is characterized by gait disturbance, cognitive impairment, with or without urinary incontinence, enlarged ventricles with or without cerebral atrophy and normal cerebrospinal fluid pressure.Methods:We report two sisters with NPH who lived together their entire lives and whose natural history might provide insights into genetic and environmental mechanisms underlying this disorder. Both patients were in their early seventies, single, had similar daily habits and hypertension. No other family members had NPH.Results:They both underwent shunt placement and showed improvement documented by history and neuropsychological assessment. Both showed a delayed deterioration due to vasculopathy. Both patients were homozygous for the apolipoprotein E (ApoE) e3 allele on chromosome 19. No environmental factors that might have influenced the development of NPH were identified.Conclusion:Our report of two sisters with NPH may indicate the presence of genetic predisposition and further studies involving genetics and environmental factors are necessary to elucidate their role in the pathogenesis of NPH.

Salomón Hakim, MD (1922–2011): A honeymoon with Neurosurgery

2021 ◽  
pp. 096777202110540
Author(s):  
Daniel Jaramillo-Velásquez ◽  
Fernando Hakim ◽  
Andreas K Demetriades
Keyword(s):  
Cerebrospinal Fluid ◽  
Normal Pressure Hydrocephalus ◽  
Medical Literature ◽  
Medical Physics ◽  
Fluid Pressure ◽  
Normal Pressure ◽  
Empirical Knowledge ◽  
Cranial Cavity ◽  
The Social ◽  
Programmable Valve

Salomón Hakim (1922–2011) was a Colombian neurosurgeon and brain scientist This biography examines the social and cultural background through which he emerged as an inquisitive and multi-dimensional surgeon-scientist, and his lifelong contributions to the specialty of neurosurgery. With empirical knowledge in applied medical physics, electronics, electricity and chemistry, he understood the paradoxical phenomenon of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. This ultimately led Hakim to describe in exquisite detail the physics of the cranial cavity and brain hydrodynamics. His name is intertwined with the identification of the entity of a syndrome which had not previously been addressed in the medical literature: Normal Pressure Hydrocephalus (Hakim's syndrome). Additionally, he designed and built various models of valved shunting devices to treat the condition (eg the Hakim programmable valve). Through his selflessness and cogent work, Hakim left a legacy and intellectual heritage that has allowed many colleagues worldwide to save thousands of lives who would be otherwise condemned to oblivion.

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