Immunohistochemical localization of chromogranin A and B in endocrine cells of the alimentary tract of the adult lizard Podarcis sicula

1993 ◽  
Vol 273 (2) ◽  
pp. 335-344 ◽  
Author(s):  
Loredana D'Este ◽  
Roberto Buffa ◽  
Carlo Casu ◽  
Nadia Carboni ◽  
Micaela Pelagi ◽  
...  
Keyword(s):  
Chromogranin A ◽  
Endocrine Cells ◽  
Alimentary Tract ◽  
Immunohistochemical Localization ◽  
Podarcis Sicula

Immunohistochemical localization of chromogranin A and B in the endocrine cells of the alimentary tract of the green frog, Rana esculenta

1994 ◽  
Vol 277 (2) ◽  
pp. 341-349 ◽  
Author(s):  
Loredana D'Este ◽  
Roberto Buffa ◽  
Micaela Pelagi ◽  
Antonio G. Siccardi ◽  
Tindaro Renda
Keyword(s):  
Chromogranin A ◽  
Endocrine Cells ◽  
Alimentary Tract ◽  
Rana Esculenta ◽  
Immunohistochemical Localization ◽  
Green Frog

Immunohistochemical localization of chromogranin A and B in the endocrine cells of the alimentary tract of the green frog, Rana esculenta

1994 ◽  
Vol 277 (2) ◽  
pp. 341-349 ◽  
Author(s):  
Loredana D'Este ◽  
Roberto Buffa ◽  
Micaela Pelagi ◽  
Antonio G. Siccardi ◽  
Tindaro Renda
Keyword(s):  
Chromogranin A ◽  
Endocrine Cells ◽  
Alimentary Tract ◽  
Rana Esculenta ◽  
Immunohistochemical Localization ◽  
Green Frog

scholarly journals Immunohistochemical Localization of Chromogranin A in Endocrine Tissues and Endocrine Tumors of Dogs

1998 ◽  
Vol 35 (4) ◽  
pp. 312-315 ◽  
Author(s):  
J. C. Doss ◽  
A. Grone ◽  
C. C. Capen ◽  
T. J. Rosol
Keyword(s):  
Chromogranin A ◽  
Chromaffin Cells ◽  
Endocrine Cells ◽  
Secretory Granules ◽  
Hormone Secretion ◽  
Immunohistochemical Localization ◽  
Endocrine Tumors ◽  
Parathyroid Adenomas ◽  
Immunohistochemical Identification ◽  
Endocrine Tissues

Chromogranin A is present in the secretory granules of endocrine cells and functions in hormone packaging, secretory granule stabilization, and regulation of hormone secretion. Immunohistochemical identification of chromogranin A can facilitate diagnosis of endocrine neoplasia. Normal and neoplastic canine tissues were stained immunohistochemically for chromogranin A. Staining of normal endocrine tissues demonstrated chromogranin A in chromaffin cells of the adrenal medulla, C cells of the thyroid gland, and pancreatic islets. The parathyroid chief cells and anterior pituitary stained lightly positive for chromogranin A. Pheochromocytomas (7/7), chemodectomas (5/7), islet cell carcinomas (2/6), pituitary adenomas (4/6), parathyroid adenomas (3/7), and a C-cell carcinoma (1/1) stained positive for chromogranin A. The data indicate that chromogranin A is widely distributed in canine endocrine tissues, and immunohistochemical staining of chromogranin A can be used to confirm the presence of secretory granules in endocrine tumors.

Immunohistochemical localization of α- and βA-subunits of inhibin/activin in human normal endocrine cells and related tumors of the digestive system

1999 ◽  
Vol 434 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Stefano La Rosa ◽  
Silvia Uccella ◽  
Paola Billo ◽  
Carla Facco ◽  
Fausto Sessa ◽  
...  
Keyword(s):  
Endocrine Cells ◽  
Digestive System ◽  
Immunohistochemical Localization

scholarly journals Increased Chromogranin A–Positive Hormone-Negative Cells in Chronic Pancreatitis

2018 ◽  
Vol 103 (6) ◽  
pp. 2126-2135 ◽  
Author(s):  
Abu Saleh Md Moin ◽  
Megan Cory ◽  
Jennifer Choi ◽  
Allison Ong ◽  
Sangeeta Dhawan ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Chromogranin A ◽  
Endocrine Cells ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Cell Regeneration ◽  
Inflammation Marker ◽  
Β Cells ◽  
Cell Frequency ◽  
Endogenous Expression

Abstract Context Chronic pancreatitis (CP) is characterized by inflammation, fibrosis, and a loss of pancreatic acinar cells, which can result in exocrine and eventually endocrine deficiency. Pancreatitis has been reported to induce formation of new endocrine cells (neogenesis) in mice. Our recent data have implicated chromogranin A–positive hormone-negative (CPHN) cells as potential evidence of neogenesis in humans. Objective We sought to establish if CPHN cells were more abundant in CP in humans. Design, Setting, and Participants We investigated the frequency and distribution of CPHN cells and the expression of the chemokine C-X-C motif ligand 10 (CXCL10) and its receptor chemokine C-X-C motif receptor 3 in pancreas of nondiabetic subjects with CP. Results CPHN cell frequency in islets was increased sevenfold in CP [2.1% ± 0.67% vs 0.35% ± 0.09% CPHN cells in islets, CP vs nonpancreatitis (NP), P < 0.01], as were the CPHN cells found as scattered cells in the exocrine areas (17.4 ± 2.9 vs 4.2 ± 0.6, CP vs NP, P < 0.001). Polyhormonal endocrine cells were also increased in CP (2.7 ± 1.2 vs 0.1 ± 0.04, CP vs NP, % of polyhormonal cells of total endocrine cells, P < 0.01), as was expression of CXCL10 in α and β cells. Conclusion There is increased islet endogenous expression of the inflammation marker CXCL10 in islets in the setting of nondiabetic CP and an increase in polyhormonal (insulin-glucagon expressing) cells. The increase in CPHN cells in CP, often in a lobular distribution, may indicate foci of attempted endocrine cell regeneration.

Chromogranin: A newly recognized marker for endocrine cells of the human gastrointestinal tract

1985 ◽  
Vol 89 (6) ◽  
pp. 1366-1373 ◽  
Author(s):  
P. Facer ◽  
A.E. Bishop ◽  
R.V. Lloyd ◽  
B.S. Wilson ◽  
R.J. Hennessy ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Chromogranin A ◽  
Endocrine Cells ◽  
Human Gastrointestinal Tract
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