Adrenergic and cholinergic nerves of bovine, guinea pig and hamster salivary glands

1973 ◽  
Vol 138 (3) ◽  
pp. 407-420 ◽  
Author(s):  
Per Alm ◽  
Gunnar D. Bloom ◽  
Bengt Carls��
Keyword(s):  
Guinea Pig ◽  
Salivary Glands ◽  
Cholinergic Nerves

Acetylcholine release from canine isolated airway is not modulated by norepinephrine

1986 ◽  
Vol 61 (3) ◽  
pp. 1025-1030 ◽  
Author(s):  
J. G. Martin ◽  
B. Collier
Keyword(s):  
Guinea Pig ◽  
Acetylcholine Release ◽  
Electrical Field Stimulation ◽  
Output Pulse ◽  
Physiological Salt Solution ◽  
Guinea Pig Ileum ◽  
Cholinergic Nerves ◽  
Ach Release ◽  
Electrical Field ◽  
Neural Origin

We measured acetylcholine (ACh) release from canine isolated tracheal smooth muscle (TSM) and bronchial spirals using a radioenzymic assay technique. Tissue was incubated in physiological salt solution containing physostigmine (3.10(-5) M), atropine (10(-7) M), and choline (5.10(-6) M), and bath fluid was collected every 15 min for assay. There was a resting release of ACh of 209 +/- 44 pmol/g tissue (mean +/- SE) from 53 to 77 specimens of TSM. Electrical field stimulation (ES) increased ACh release, which was blocked by tetrodotoxin (10(-6) g/ml), confirming the neural origin of ACh. The ACh output during ES (2-ms pulses) at 10 Hz increased linearly from 188 +/- 50 pmol/g tissue (mean +/- SE) for a 1-min volley, to 323 +/- 57 for three volleys, and 544 +/- 128 for five volleys. The ACh output/pulse was constant during ES at 20, 15, 10, and 5 Hz, but it was significantly higher at 2 than at 5 Hz (P less than 0.005). Incubation of TSM with norepinephrine (NE, 10(-5) M) did not affect ACh output either at 2 or 10 Hz. Likewise, ACh output from bronchial spirals during ES and 2 Hz was unaffected by NE. In contrast, NE treatment of isolated guinea pig ileum reduced the ACh released by ES at 2 Hz to 40 +/- 7% (P less than 0.001) of the control ACh output. It is concluded that evoked release of ACh (output/pulse) from cholinergic nerves in canine airway is frequency dependent, as in guinea pig ileum, but that, unlike guinea pig ileum, NE does not modulate its release.

EXPERIMENTS ON ATROPINE-RESISTANT VASODILATATION IN SALIVARY GLANDS

1963 ◽  
Vol 41 (2) ◽  
pp. 519-524 ◽  
Author(s):  
B. C. R. Strömblad ◽  
Peter E. Dresel
Keyword(s):  
Salivary Glands ◽  
Blocking Effect ◽  
Nerve Supply ◽  
Parotid Glands ◽  
Cholinergic Nerves ◽  
Parasympathetic Nerve ◽  
Ganglionic Transmission ◽  
Stimulation Of

Vasodilatation induced by stimulation of the parasympathetic nerve supply to the submaxillary and the parotid glands has long been known to be resistant to the blocking effect of atropine. We have found that dichloroisoproterenol does not block this vasodilatation, that d-tubocurarine blocks it by interfering with ganglionic transmission, and that a hemicholinium, HC-3, blocks it gradually under conditions in which interference with ganglionic transmission is excluded. It is concluded that the mechanism of vasodilatation includes the action of cholinergic nerves.

Lack of effect of botulinum toxin on nonadrenergic, noncholinergic inhibitory responses of the guinea pig fundus in vitro

1980 ◽  
Vol 58 (1) ◽  
pp. 88-92 ◽  
Author(s):  
M. L. Paul ◽  
M. A. Cook
Keyword(s):  
Botulinum Toxin ◽  
Guinea Pig ◽  
Electrical Field Stimulation ◽  
Field Stimulation ◽  
Cholinergic Nerves ◽  
Electrical Field

The nonadrenergic, noncholinergic inhibitory (NAI) response of guinea pig fundic strip to electrical field stimulation was examined in the presence of botulinum toxin and tetrodotoxin. Tetrodotoxin completely abolished the NAI response while botulinum toxin did not alter it. It is concluded that the mediator of NAI responses is unlikely to be released with acetylcholine from cholinergic nerves or that such release would have to occur by a mechanism resistant to botulinum toxin.

Acomparative study of Lipomatosis in the Salivary Glands of Mammals with special reference to the Echindna.

1958 ◽  
Vol 6 (2) ◽  
pp. 145
Author(s):  
R Tucker
Keyword(s):  
Connective Tissue ◽  
Guinea Pig ◽  
Rhesus Monkey ◽  
Special Reference ◽  
Salivary Glands ◽  
The Other ◽  
Different Types ◽  
Glandular Cells ◽  
Complete Transformation

The occurrence, site, and morphology of lipomatic changes in the salivary glands of the pig, sheep, cattle, horse, dog, goat, rhesus monkey, guinea pig, bandicoot, rabbit, and the echidna were investigated, special attention being given to the glands of the echidna. The areal, tubular, acinar, marginal, central, interlobular, peritubular, paratrabecular, and capsular accumulations were described. It was concluded that lipomatic changes in the salivary glands are of two distinctly different types, one being the formation of fatty cells from the cells of the connective tissue and the other being the partial or complete transformation of the glandular cells into fatty cells.

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