Antioxidant drug mechanisms: transition metal-binding and vasodilation

1992 ◽  
Vol 116 (2) ◽  
pp. 105-111 ◽  
Author(s):  
William B. Weglicki ◽  
I. Tong Mak
Keyword(s):  
Transition Metal ◽  
Metal Binding

scholarly journals Structure and Metal Binding Properties of Chlamydia trachomatis YtgA

2019 ◽  
Vol 202 (1) ◽  
Author(s):  
Zhenyao Luo ◽  
Stephanie L. Neville ◽  
Rebecca Campbell ◽  
Jacqueline R. Morey ◽  
Shruti Menon ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Transition Metal ◽  
Metal Binding ◽  
Developed Countries ◽  
Biochemical Properties ◽  
Host Cells ◽  
Transmitted Infection ◽  
Content Type ◽  
Sexually Transmitted ◽  
Serious Disease

Chlamydia trachomatis is the most common bacterial sexually transmitted infection in developed countries, with an estimated global prevalence of 4.2% in the 15- to 49-year age group. Although infection is asymptomatic in more than 80% of infected women, about 10% of cases result in serious disease. Infection by C. trachomatis is dependent on the ability to acquire essential nutrients, such as the transition metal iron, from host cells. In this study, we show that iron is the most abundant transition metal in C. trachomatis and report the structural and biochemical properties of the iron-recruiting protein YtgA. Knowledge of the high-resolution structure of YtgA will provide a platform for future structure-based antimicrobial design approaches.

Transition-metal binding site of bleomycin. A synthetic analog capable of binding iron(II) to yield an oxygen-sensitive complex

1981 ◽  
Vol 103 (23) ◽  
pp. 6986-6988 ◽  
Author(s):  
Masami Otsuka ◽  
Makoto Yoshida ◽  
Susumu Kobayashi ◽  
Masaji Ohno ◽  
Yukio Sugiura ◽  
...  
Keyword(s):  
Transition Metal ◽  
Binding Site ◽  
Metal Binding ◽  
Synthetic Analog ◽  
Metal Binding Site ◽  
Oxygen Sensitive

Transition-metal binding site of bleomycin. A remarkably efficient dioxygen-activating molecule based on bleomycin-Fe(II) complex

1986 ◽  
Vol 27 (31) ◽  
pp. 3631-3634 ◽  
Author(s):  
Atsushi Kittaka ◽  
Yuichi Sugano ◽  
Masami Otsuka ◽  
Masaji Ohno ◽  
Yukio Sugiura ◽  
...  
Keyword(s):  
Transition Metal ◽  
Binding Site ◽  
Metal Binding ◽  
Metal Binding Site

Prediction of transition metal-binding sites from apo protein structures

2007 ◽  
Vol 70 (1) ◽  
pp. 208-217 ◽  
Author(s):  
Mariana Babor ◽  
Sergey Gerzon ◽  
Barak Raveh ◽  
Vladimir Sobolev ◽  
Marvin Edelman
Keyword(s):  
Transition Metal ◽  
Metal Binding ◽  
Binding Sites ◽  
Protein Structures ◽  
Metal Binding Sites
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