Regional cerebral blood flow measured with N-isopropyl-p-[123I]iodoamphetamine single-photon emission tomography in patients with Joseph disease

1994 ◽  
Vol 21 (7) ◽  
pp. 615-620 ◽  
Author(s):  
Naoya Takahashi ◽  
Ikuo Odano ◽  
Mamiko Nishihara ◽  
Tatsuhiko Yuasa ◽  
Kunio Sakai
1991 ◽  
Vol 158 (4) ◽  
pp. 558-562 ◽  
Author(s):  
Ken Wilson ◽  
David Bowen ◽  
Paul Francis ◽  
Philippa Tyrrell

Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.


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